Association between lipid profiles and Graves orbitopathy: A systematic review and meta analysis
Introduction: Graves orbitopathy (GO) is an autoimmune disorder affecting the tissues around the eyes, seen in 25–50 % of individuals with Graves disease (GD). Thyroid receptor antibodies (TRAb) target the TSH receptor, which can provoke an inflammatory response and promote fat cell formation by act...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Endocrine and Metabolic Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666396125000202 |
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| author | Nanny Natalia Mulyani Soetedjo Louis Fabio Jonathan Jusni Eric Ricardo Yonatan Steven Alvianto Nicolas Daniel Widjanarko Hikmat Permana |
| author_facet | Nanny Natalia Mulyani Soetedjo Louis Fabio Jonathan Jusni Eric Ricardo Yonatan Steven Alvianto Nicolas Daniel Widjanarko Hikmat Permana |
| author_sort | Nanny Natalia Mulyani Soetedjo |
| collection | DOAJ |
| description | Introduction: Graves orbitopathy (GO) is an autoimmune disorder affecting the tissues around the eyes, seen in 25–50 % of individuals with Graves disease (GD). Thyroid receptor antibodies (TRAb) target the TSH receptor, which can provoke an inflammatory response and promote fat cell formation by activating these receptors. Given this mechanism, statins that are commonly used for managing hyperlipidemia could be a potential treatment for GO. This review explores the connection between Graves orbitopathy and lipid profiles. Method: This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Articles were sourced from databases such as MEDLINE, ScienceDirect, EBSCO, ProQuest, Cochrane, and Google Scholar. The inclusion criteria covered both published and unpublished studies examining the relationship between GO and lipid profiles. Meta-analysis was conducted using Review Manager 5.4, and the risk of bias was evaluated using the Newcastle-Ottawa Scale (NOS). Result: This review included a total of four cross-sectional studies. All studies found a significant association between LDL cholesterol levels and Graves orbitopathy. However, the relationships with triglycerides (TG), HDL levels, and total cholesterol (TC) were not consistently statistically significant. The meta-analysis revealed significant differences in TC, LDL cholesterol, and TG levels across all groups (SMD = 0.48, CI = 0.17–0.80, p = 0.002, I2 = 67 %; SMD = 0.42, CI = 0.18–0.67, p = 0.0008, I2 = 47 %; SMD = 0.24, CI = 0.07–0.41, p = 0.005, I2 = 0 %, respectively), while HDL levels did not show significant differences among the groups (SMD = 0.16, CI = −0.02-0.34, p = 0.08, I2 = 10 %). Conclusion: Significant differences in serum lipid profiles, including TC, LDL, and TG except HDL, were found between patients with GO and those without. Further research is needed to confirm these findings. |
| format | Article |
| id | doaj-art-86465c1ad2ea4ea68b61b07db26d9727 |
| institution | OA Journals |
| issn | 2666-3961 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Endocrine and Metabolic Science |
| spelling | doaj-art-86465c1ad2ea4ea68b61b07db26d97272025-08-20T02:26:09ZengElsevierEndocrine and Metabolic Science2666-39612025-06-011810023410.1016/j.endmts.2025.100234Association between lipid profiles and Graves orbitopathy: A systematic review and meta analysisNanny Natalia Mulyani Soetedjo0Louis Fabio Jonathan Jusni1Eric Ricardo Yonatan2Steven Alvianto3Nicolas Daniel Widjanarko4Hikmat Permana5Endocrine and Metabolic Division, Department of Internal Medicine, Faculty of Medicine Padjadjaran University, Hasan Sadikin General Hospital, Bandung, West Java, Indonesia; Corresponding author at: Endocrine and Metabolic Division, Department of Internal Medicine, Faculty of Medicine Padjadjaran University, Hasan Sadikin General Hospital, Pasteur Street No.38, Pasteur, Sukajadi District, Bandung City, West Java 40161, Indonesia.School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, IndonesiaSchool of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, IndonesiaSchool of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, IndonesiaSchool of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, IndonesiaEndocrine and Metabolic Division, Department of Internal Medicine, Faculty of Medicine Padjadjaran University, Hasan Sadikin General Hospital, Bandung, West Java, IndonesiaIntroduction: Graves orbitopathy (GO) is an autoimmune disorder affecting the tissues around the eyes, seen in 25–50 % of individuals with Graves disease (GD). Thyroid receptor antibodies (TRAb) target the TSH receptor, which can provoke an inflammatory response and promote fat cell formation by activating these receptors. Given this mechanism, statins that are commonly used for managing hyperlipidemia could be a potential treatment for GO. This review explores the connection between Graves orbitopathy and lipid profiles. Method: This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Articles were sourced from databases such as MEDLINE, ScienceDirect, EBSCO, ProQuest, Cochrane, and Google Scholar. The inclusion criteria covered both published and unpublished studies examining the relationship between GO and lipid profiles. Meta-analysis was conducted using Review Manager 5.4, and the risk of bias was evaluated using the Newcastle-Ottawa Scale (NOS). Result: This review included a total of four cross-sectional studies. All studies found a significant association between LDL cholesterol levels and Graves orbitopathy. However, the relationships with triglycerides (TG), HDL levels, and total cholesterol (TC) were not consistently statistically significant. The meta-analysis revealed significant differences in TC, LDL cholesterol, and TG levels across all groups (SMD = 0.48, CI = 0.17–0.80, p = 0.002, I2 = 67 %; SMD = 0.42, CI = 0.18–0.67, p = 0.0008, I2 = 47 %; SMD = 0.24, CI = 0.07–0.41, p = 0.005, I2 = 0 %, respectively), while HDL levels did not show significant differences among the groups (SMD = 0.16, CI = −0.02-0.34, p = 0.08, I2 = 10 %). Conclusion: Significant differences in serum lipid profiles, including TC, LDL, and TG except HDL, were found between patients with GO and those without. Further research is needed to confirm these findings.http://www.sciencedirect.com/science/article/pii/S2666396125000202Graves OrbitopathyTriglyceridesHDLLDLTotal cholesterol |
| spellingShingle | Nanny Natalia Mulyani Soetedjo Louis Fabio Jonathan Jusni Eric Ricardo Yonatan Steven Alvianto Nicolas Daniel Widjanarko Hikmat Permana Association between lipid profiles and Graves orbitopathy: A systematic review and meta analysis Endocrine and Metabolic Science Graves Orbitopathy Triglycerides HDL LDL Total cholesterol |
| title | Association between lipid profiles and Graves orbitopathy: A systematic review and meta analysis |
| title_full | Association between lipid profiles and Graves orbitopathy: A systematic review and meta analysis |
| title_fullStr | Association between lipid profiles and Graves orbitopathy: A systematic review and meta analysis |
| title_full_unstemmed | Association between lipid profiles and Graves orbitopathy: A systematic review and meta analysis |
| title_short | Association between lipid profiles and Graves orbitopathy: A systematic review and meta analysis |
| title_sort | association between lipid profiles and graves orbitopathy a systematic review and meta analysis |
| topic | Graves Orbitopathy Triglycerides HDL LDL Total cholesterol |
| url | http://www.sciencedirect.com/science/article/pii/S2666396125000202 |
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