Development and validation of an interpretable risk prediction model for perioperative ischemic stroke in noncardiac, nonvascular, and nonneurosurgical patients: a retrospective study
BackgroundPerioperative stroke is a severe complication for patients undergoing non-cardiac, non-vascular, and non-neurosurgical surgeries, resulting in significant morbidity and mortality. Despite its clinical relevance, effective predictive models for stroke risk in this population are scarce. Thi...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-07-01
|
| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2025.1628475/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849728218664271872 |
|---|---|
| author | Xuhui Cong Xuli Zou Ruilou Zhu Yubao Li Lu Liu Jiaqiang Zhang |
| author_facet | Xuhui Cong Xuli Zou Ruilou Zhu Yubao Li Lu Liu Jiaqiang Zhang |
| author_sort | Xuhui Cong |
| collection | DOAJ |
| description | BackgroundPerioperative stroke is a severe complication for patients undergoing non-cardiac, non-vascular, and non-neurosurgical surgeries, resulting in significant morbidity and mortality. Despite its clinical relevance, effective predictive models for stroke risk in this population are scarce. This study seeks to develop and validate an interpretable predictive model that incorporates essential perioperative variables to assess stroke risk. The goal is to enhance risk stratification and support more informed clinical decision-making.MethodsA retrospective cohort study included 106,328 patients aged 18 years or older who underwent non-cardiac, non-vascular, and non-neurosurgical surgeries at our institution. The development cohort comprised 74,429 patients, with 140 perioperative stroke incidents, while the validation cohort consisted of 31,899 patients, with 59 incidents. Risk factors for perioperative stroke were identified using univariable logistic regression analysis. The Least Absolute Shrinkage and Selection Operator (LASSO) regression method was applied to select variables, followed by the development, validation, and performance evaluation of the predictive model using multivariate logistic regression analysis.ResultsThe prediction model, developed using nine variables including demographic information, medical history, and pre- and post-operative data, demonstrated strong discriminatory power in predicting perioperative stroke (AUC = 0.869; 95% CI, 0.827–0.910). It also exhibited an excellent fit with the validation cohort (Hosmer–Lemeshow test, χ2 = 6.877, P = 0.650). Additionally, the SHAP (Shapley Additive Explanations) interpretability model was integrated to enhance the model’s transparency, allowing clinicians to better understand the contribution of each predictor. Decision curve analysis confirmed the model’s significant net benefit, further validating its clinical utility.ConclusionThis study developed and validated a robust predictive model for perioperative stroke risk in patients undergoing non-cardiac, non-vascular, and non-neurosurgical procedures. Despite its retrospective design, the model exhibited strong performance and clinical relevance. It provides a solid foundation for future multi-center studies aimed at refining and expanding its applicability. |
| format | Article |
| id | doaj-art-863e8cbdfd9d4a879b85a07a96192ad5 |
| institution | DOAJ |
| issn | 1664-042X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj-art-863e8cbdfd9d4a879b85a07a96192ad52025-08-20T03:09:35ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2025-07-011610.3389/fphys.2025.16284751628475Development and validation of an interpretable risk prediction model for perioperative ischemic stroke in noncardiac, nonvascular, and nonneurosurgical patients: a retrospective studyXuhui Cong0Xuli Zou1Ruilou Zhu2Yubao Li3Lu Liu4Jiaqiang Zhang5Department of Anesthesia and Perioperative Medicine, Zhengzhou University People’s Hospital and Henan Provincial People’s Hospital, Zhengzhou, Henan, ChinaDepartment of Anesthesia and Perioperative Medicine, Zhengzhou University People’s Hospital and Henan Provincial People’s Hospital, Zhengzhou, Henan, ChinaDepartment of Anesthesia and Perioperative Medicine, Zhengzhou University People’s Hospital and Henan Provincial People’s Hospital, Zhengzhou, Henan, ChinaXinxiang Medical University, Xinxiang, Henan, ChinaZhengzhou University, Zhengzhou, Henan, ChinaDepartment of Anesthesia and Perioperative Medicine, Zhengzhou University People’s Hospital and Henan Provincial People’s Hospital, Zhengzhou, Henan, ChinaBackgroundPerioperative stroke is a severe complication for patients undergoing non-cardiac, non-vascular, and non-neurosurgical surgeries, resulting in significant morbidity and mortality. Despite its clinical relevance, effective predictive models for stroke risk in this population are scarce. This study seeks to develop and validate an interpretable predictive model that incorporates essential perioperative variables to assess stroke risk. The goal is to enhance risk stratification and support more informed clinical decision-making.MethodsA retrospective cohort study included 106,328 patients aged 18 years or older who underwent non-cardiac, non-vascular, and non-neurosurgical surgeries at our institution. The development cohort comprised 74,429 patients, with 140 perioperative stroke incidents, while the validation cohort consisted of 31,899 patients, with 59 incidents. Risk factors for perioperative stroke were identified using univariable logistic regression analysis. The Least Absolute Shrinkage and Selection Operator (LASSO) regression method was applied to select variables, followed by the development, validation, and performance evaluation of the predictive model using multivariate logistic regression analysis.ResultsThe prediction model, developed using nine variables including demographic information, medical history, and pre- and post-operative data, demonstrated strong discriminatory power in predicting perioperative stroke (AUC = 0.869; 95% CI, 0.827–0.910). It also exhibited an excellent fit with the validation cohort (Hosmer–Lemeshow test, χ2 = 6.877, P = 0.650). Additionally, the SHAP (Shapley Additive Explanations) interpretability model was integrated to enhance the model’s transparency, allowing clinicians to better understand the contribution of each predictor. Decision curve analysis confirmed the model’s significant net benefit, further validating its clinical utility.ConclusionThis study developed and validated a robust predictive model for perioperative stroke risk in patients undergoing non-cardiac, non-vascular, and non-neurosurgical procedures. Despite its retrospective design, the model exhibited strong performance and clinical relevance. It provides a solid foundation for future multi-center studies aimed at refining and expanding its applicability.https://www.frontiersin.org/articles/10.3389/fphys.2025.1628475/fullprediction modelrisk assessmentperioperative strokenoncardiacnonvascularand nonneurosurgical procedures |
| spellingShingle | Xuhui Cong Xuli Zou Ruilou Zhu Yubao Li Lu Liu Jiaqiang Zhang Development and validation of an interpretable risk prediction model for perioperative ischemic stroke in noncardiac, nonvascular, and nonneurosurgical patients: a retrospective study Frontiers in Physiology prediction model risk assessment perioperative stroke noncardiac nonvascular and nonneurosurgical procedures |
| title | Development and validation of an interpretable risk prediction model for perioperative ischemic stroke in noncardiac, nonvascular, and nonneurosurgical patients: a retrospective study |
| title_full | Development and validation of an interpretable risk prediction model for perioperative ischemic stroke in noncardiac, nonvascular, and nonneurosurgical patients: a retrospective study |
| title_fullStr | Development and validation of an interpretable risk prediction model for perioperative ischemic stroke in noncardiac, nonvascular, and nonneurosurgical patients: a retrospective study |
| title_full_unstemmed | Development and validation of an interpretable risk prediction model for perioperative ischemic stroke in noncardiac, nonvascular, and nonneurosurgical patients: a retrospective study |
| title_short | Development and validation of an interpretable risk prediction model for perioperative ischemic stroke in noncardiac, nonvascular, and nonneurosurgical patients: a retrospective study |
| title_sort | development and validation of an interpretable risk prediction model for perioperative ischemic stroke in noncardiac nonvascular and nonneurosurgical patients a retrospective study |
| topic | prediction model risk assessment perioperative stroke noncardiac nonvascular and nonneurosurgical procedures |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2025.1628475/full |
| work_keys_str_mv | AT xuhuicong developmentandvalidationofaninterpretableriskpredictionmodelforperioperativeischemicstrokeinnoncardiacnonvascularandnonneurosurgicalpatientsaretrospectivestudy AT xulizou developmentandvalidationofaninterpretableriskpredictionmodelforperioperativeischemicstrokeinnoncardiacnonvascularandnonneurosurgicalpatientsaretrospectivestudy AT ruilouzhu developmentandvalidationofaninterpretableriskpredictionmodelforperioperativeischemicstrokeinnoncardiacnonvascularandnonneurosurgicalpatientsaretrospectivestudy AT yubaoli developmentandvalidationofaninterpretableriskpredictionmodelforperioperativeischemicstrokeinnoncardiacnonvascularandnonneurosurgicalpatientsaretrospectivestudy AT luliu developmentandvalidationofaninterpretableriskpredictionmodelforperioperativeischemicstrokeinnoncardiacnonvascularandnonneurosurgicalpatientsaretrospectivestudy AT jiaqiangzhang developmentandvalidationofaninterpretableriskpredictionmodelforperioperativeischemicstrokeinnoncardiacnonvascularandnonneurosurgicalpatientsaretrospectivestudy |