The Molecular Basis of Polycystic Ovary Syndrome and Its Cardiometabolic Correlates: Exploring the Intersection and Its Clinical Implications—A Narrative Review
Recent studies have highlighted the association between polycystic ovary syndrome (PCOS) and cardiometabolic diseases, leading to an improved understanding of the underlying mechanistic factors. PCOS significantly increases cardiovascular risk by predisposing individuals to various subclinical and c...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-03-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/13/3/709 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850089946234224640 |
|---|---|
| author | Jasmin Mahabamunuge Nicole M. Sekula Christina Lepore Meghana Kudrimoti Animesh Upadhyay Khadija Alshowaikh Howard J. Li David B. Seifer Abdelrahman AlAshqar |
| author_facet | Jasmin Mahabamunuge Nicole M. Sekula Christina Lepore Meghana Kudrimoti Animesh Upadhyay Khadija Alshowaikh Howard J. Li David B. Seifer Abdelrahman AlAshqar |
| author_sort | Jasmin Mahabamunuge |
| collection | DOAJ |
| description | Recent studies have highlighted the association between polycystic ovary syndrome (PCOS) and cardiometabolic diseases, leading to an improved understanding of the underlying mechanistic factors. PCOS significantly increases cardiovascular risk by predisposing individuals to various subclinical and clinical conditions, including atherosclerosis and type 2 diabetes mellitus. Additionally, it interacts synergistically with other traditional cardiovascular risk factors, such as obesity, hyperlipidemia, and insulin resistance. Several molecular mechanisms involving genetics, epigenetics, adipokine secretion, hyperandrogenemia, and hyperinsulinemia play a role in the relationship between PCOS and these comorbidities. For instance, androgen excess has been implicated in the development of hypertension, type 2 diabetes mellitus, endothelial dysfunction, and ultimately, broader cardiovascular disease. A deeper understanding of these underlying mechanisms facilitates the development of diagnostic, preventative, and therapeutic strategies directed at reducing cardiometabolic morbidity. This narrative review summarizes the current evidence, explores the potential clinical implications of these findings, and discusses emerging therapies to reduce cardiometabolic morbidity in women with PCOS. |
| format | Article |
| id | doaj-art-8633bd9c19e54faa977954a3e59eb0a5 |
| institution | DOAJ |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-8633bd9c19e54faa977954a3e59eb0a52025-08-20T02:42:39ZengMDPI AGBiomedicines2227-90592025-03-0113370910.3390/biomedicines13030709The Molecular Basis of Polycystic Ovary Syndrome and Its Cardiometabolic Correlates: Exploring the Intersection and Its Clinical Implications—A Narrative ReviewJasmin Mahabamunuge0Nicole M. Sekula1Christina Lepore2Meghana Kudrimoti3Animesh Upadhyay4Khadija Alshowaikh5Howard J. Li6David B. Seifer7Abdelrahman AlAshqar8Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT 06510, USADepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT 06510, USADepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT 06510, USADepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT 06510, USADepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT 06510, USADepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT 06510, USADivision of Reproductive Endocrinology and Infertility, National Institutes of Health, Bethesda, MD 20892, USADivision of Reproductive Endocrinology and Infertility, Yale School of Medicine, New Haven, CT 06510, USADepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT 06510, USARecent studies have highlighted the association between polycystic ovary syndrome (PCOS) and cardiometabolic diseases, leading to an improved understanding of the underlying mechanistic factors. PCOS significantly increases cardiovascular risk by predisposing individuals to various subclinical and clinical conditions, including atherosclerosis and type 2 diabetes mellitus. Additionally, it interacts synergistically with other traditional cardiovascular risk factors, such as obesity, hyperlipidemia, and insulin resistance. Several molecular mechanisms involving genetics, epigenetics, adipokine secretion, hyperandrogenemia, and hyperinsulinemia play a role in the relationship between PCOS and these comorbidities. For instance, androgen excess has been implicated in the development of hypertension, type 2 diabetes mellitus, endothelial dysfunction, and ultimately, broader cardiovascular disease. A deeper understanding of these underlying mechanisms facilitates the development of diagnostic, preventative, and therapeutic strategies directed at reducing cardiometabolic morbidity. This narrative review summarizes the current evidence, explores the potential clinical implications of these findings, and discusses emerging therapies to reduce cardiometabolic morbidity in women with PCOS.https://www.mdpi.com/2227-9059/13/3/709cardiovascular diseasediabetes mellitushypertensionmetabolic syndromeobesitypolycystic ovary |
| spellingShingle | Jasmin Mahabamunuge Nicole M. Sekula Christina Lepore Meghana Kudrimoti Animesh Upadhyay Khadija Alshowaikh Howard J. Li David B. Seifer Abdelrahman AlAshqar The Molecular Basis of Polycystic Ovary Syndrome and Its Cardiometabolic Correlates: Exploring the Intersection and Its Clinical Implications—A Narrative Review Biomedicines cardiovascular disease diabetes mellitus hypertension metabolic syndrome obesity polycystic ovary |
| title | The Molecular Basis of Polycystic Ovary Syndrome and Its Cardiometabolic Correlates: Exploring the Intersection and Its Clinical Implications—A Narrative Review |
| title_full | The Molecular Basis of Polycystic Ovary Syndrome and Its Cardiometabolic Correlates: Exploring the Intersection and Its Clinical Implications—A Narrative Review |
| title_fullStr | The Molecular Basis of Polycystic Ovary Syndrome and Its Cardiometabolic Correlates: Exploring the Intersection and Its Clinical Implications—A Narrative Review |
| title_full_unstemmed | The Molecular Basis of Polycystic Ovary Syndrome and Its Cardiometabolic Correlates: Exploring the Intersection and Its Clinical Implications—A Narrative Review |
| title_short | The Molecular Basis of Polycystic Ovary Syndrome and Its Cardiometabolic Correlates: Exploring the Intersection and Its Clinical Implications—A Narrative Review |
| title_sort | molecular basis of polycystic ovary syndrome and its cardiometabolic correlates exploring the intersection and its clinical implications a narrative review |
| topic | cardiovascular disease diabetes mellitus hypertension metabolic syndrome obesity polycystic ovary |
| url | https://www.mdpi.com/2227-9059/13/3/709 |
| work_keys_str_mv | AT jasminmahabamunuge themolecularbasisofpolycysticovarysyndromeanditscardiometaboliccorrelatesexploringtheintersectionanditsclinicalimplicationsanarrativereview AT nicolemsekula themolecularbasisofpolycysticovarysyndromeanditscardiometaboliccorrelatesexploringtheintersectionanditsclinicalimplicationsanarrativereview AT christinalepore themolecularbasisofpolycysticovarysyndromeanditscardiometaboliccorrelatesexploringtheintersectionanditsclinicalimplicationsanarrativereview AT meghanakudrimoti themolecularbasisofpolycysticovarysyndromeanditscardiometaboliccorrelatesexploringtheintersectionanditsclinicalimplicationsanarrativereview AT animeshupadhyay themolecularbasisofpolycysticovarysyndromeanditscardiometaboliccorrelatesexploringtheintersectionanditsclinicalimplicationsanarrativereview AT khadijaalshowaikh themolecularbasisofpolycysticovarysyndromeanditscardiometaboliccorrelatesexploringtheintersectionanditsclinicalimplicationsanarrativereview AT howardjli themolecularbasisofpolycysticovarysyndromeanditscardiometaboliccorrelatesexploringtheintersectionanditsclinicalimplicationsanarrativereview AT davidbseifer themolecularbasisofpolycysticovarysyndromeanditscardiometaboliccorrelatesexploringtheintersectionanditsclinicalimplicationsanarrativereview AT abdelrahmanalashqar themolecularbasisofpolycysticovarysyndromeanditscardiometaboliccorrelatesexploringtheintersectionanditsclinicalimplicationsanarrativereview AT jasminmahabamunuge molecularbasisofpolycysticovarysyndromeanditscardiometaboliccorrelatesexploringtheintersectionanditsclinicalimplicationsanarrativereview AT nicolemsekula molecularbasisofpolycysticovarysyndromeanditscardiometaboliccorrelatesexploringtheintersectionanditsclinicalimplicationsanarrativereview AT christinalepore molecularbasisofpolycysticovarysyndromeanditscardiometaboliccorrelatesexploringtheintersectionanditsclinicalimplicationsanarrativereview AT meghanakudrimoti molecularbasisofpolycysticovarysyndromeanditscardiometaboliccorrelatesexploringtheintersectionanditsclinicalimplicationsanarrativereview AT animeshupadhyay molecularbasisofpolycysticovarysyndromeanditscardiometaboliccorrelatesexploringtheintersectionanditsclinicalimplicationsanarrativereview AT khadijaalshowaikh molecularbasisofpolycysticovarysyndromeanditscardiometaboliccorrelatesexploringtheintersectionanditsclinicalimplicationsanarrativereview AT howardjli molecularbasisofpolycysticovarysyndromeanditscardiometaboliccorrelatesexploringtheintersectionanditsclinicalimplicationsanarrativereview AT davidbseifer molecularbasisofpolycysticovarysyndromeanditscardiometaboliccorrelatesexploringtheintersectionanditsclinicalimplicationsanarrativereview AT abdelrahmanalashqar molecularbasisofpolycysticovarysyndromeanditscardiometaboliccorrelatesexploringtheintersectionanditsclinicalimplicationsanarrativereview |