Efficacy and Safety of Aflibercept Biosimilars Relative to Reference Aflibercept Therapy for Neovascular Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis
Hazem Saleh Aljuhani,1,* Rahaf A Hubayni,2,3,* Jumanah Qedair,2,3 Ziad M Bukhari,4 Ahmed Alzahrani,4 Razan Osama Bawazir,2,3 Orjwan Salah Badghaish,2,3 Faisal Alqahtani5 1Ophthalmology Department, Jeddah Eye Hospital, Jeddah, Saudi Arabia; 2College of Medicine, King Saud bin...
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Dove Medical Press
2025-06-01
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| author | Aljuhani HS Hubayni RA Qedair J Bukhari ZM Alzahrani A Bawazir RO Badghaish OS Alqahtani F |
| author_facet | Aljuhani HS Hubayni RA Qedair J Bukhari ZM Alzahrani A Bawazir RO Badghaish OS Alqahtani F |
| author_sort | Aljuhani HS |
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| description | Hazem Saleh Aljuhani,1,* Rahaf A Hubayni,2,3,* Jumanah Qedair,2,3 Ziad M Bukhari,4 Ahmed Alzahrani,4 Razan Osama Bawazir,2,3 Orjwan Salah Badghaish,2,3 Faisal Alqahtani5 1Ophthalmology Department, Jeddah Eye Hospital, Jeddah, Saudi Arabia; 2College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia; 3King Abdullah International Medical Research Center, Jeddah, Saudi Arabia; 4Ophthalmology Department, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Jeddah, Saudi Arabia; 5Vitreoretinal Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia*These authors contributed equally to this workCorrespondence: Hazem Saleh Aljuhani, Ophthalmology Department, Jeddah Eye Hospital, Jeddah, Saudi Arabia, Tel +966545254296, Email Aljuhanihazem@gmail.comPurpose: To assess the efficacy and safety of aflibercept biosimilars compared to reference aflibercept therapy for neovascular age-related macular degeneration (nAMD) through a systematic review and meta-analysis.Methods: A comprehensive literature search was conducted across multiple databases. Randomized controlled trials comparing intravitreal aflibercept biosimilars with reference aflibercept in patients with nAMD were included. The outcomes were changes in best-corrected visual acuity (BCVA), retinal thickness, choroidal neovascularization (CNV) leakage area from baseline based on fluorescein angiography, and adverse events.Results: Five studies involving 2,039 patients were included. No statistically significant differences were found between aflibercept biosimilars and reference aflibercept in terms of BCVA (weighted mean difference [WMD]: 1.05; 95% CI: − 0.62 to 2.71; p = 0.22), central subfield thickness (WMD: 3.33; 95% CI: − 14.48 to 21.14; p = 0.71), or CNV (WMD: − 0.23; 95% CI: − 0.58 to 0.12; p = 0.20). SThe incidence of treatment-emergent adverse events was similar between groups.Conclusion: Aflibercept biosimilars demonstrated comparable efficacy and safety profiles to reference aflibercept in the treatment of nAMD. These findings suggest that biosimilars may serve as a cost-effective alternative without compromising patient outcomes.Keywords: neovascular age-related macular degeneration, nAMD, aflibercept, biosimilars, anti-VEGF therapy, efficacy, safety |
| format | Article |
| id | doaj-art-8632f003db7c4c71997e7b22d165ec60 |
| institution | Kabale University |
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| language | English |
| publishDate | 2025-06-01 |
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| series | Clinical Ophthalmology |
| spelling | doaj-art-8632f003db7c4c71997e7b22d165ec602025-08-20T03:32:36ZengDove Medical PressClinical Ophthalmology1177-54832025-06-01Volume 19Issue 119111918104064Efficacy and Safety of Aflibercept Biosimilars Relative to Reference Aflibercept Therapy for Neovascular Age-Related Macular Degeneration: A Systematic Review and Meta-AnalysisAljuhani HS0Hubayni RA1Qedair J2Bukhari ZM3Alzahrani A4Bawazir RO5Badghaish OS6Alqahtani F7Ophthalmology departmentCollege of MedicineCollege of MedicineOphthalmology DepartmentOphthalmology DepartmentCollege of MedicineCollege of MedicineVitreoretinal divisionHazem Saleh Aljuhani,1,* Rahaf A Hubayni,2,3,* Jumanah Qedair,2,3 Ziad M Bukhari,4 Ahmed Alzahrani,4 Razan Osama Bawazir,2,3 Orjwan Salah Badghaish,2,3 Faisal Alqahtani5 1Ophthalmology Department, Jeddah Eye Hospital, Jeddah, Saudi Arabia; 2College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia; 3King Abdullah International Medical Research Center, Jeddah, Saudi Arabia; 4Ophthalmology Department, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Jeddah, Saudi Arabia; 5Vitreoretinal Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia*These authors contributed equally to this workCorrespondence: Hazem Saleh Aljuhani, Ophthalmology Department, Jeddah Eye Hospital, Jeddah, Saudi Arabia, Tel +966545254296, Email Aljuhanihazem@gmail.comPurpose: To assess the efficacy and safety of aflibercept biosimilars compared to reference aflibercept therapy for neovascular age-related macular degeneration (nAMD) through a systematic review and meta-analysis.Methods: A comprehensive literature search was conducted across multiple databases. Randomized controlled trials comparing intravitreal aflibercept biosimilars with reference aflibercept in patients with nAMD were included. The outcomes were changes in best-corrected visual acuity (BCVA), retinal thickness, choroidal neovascularization (CNV) leakage area from baseline based on fluorescein angiography, and adverse events.Results: Five studies involving 2,039 patients were included. No statistically significant differences were found between aflibercept biosimilars and reference aflibercept in terms of BCVA (weighted mean difference [WMD]: 1.05; 95% CI: − 0.62 to 2.71; p = 0.22), central subfield thickness (WMD: 3.33; 95% CI: − 14.48 to 21.14; p = 0.71), or CNV (WMD: − 0.23; 95% CI: − 0.58 to 0.12; p = 0.20). SThe incidence of treatment-emergent adverse events was similar between groups.Conclusion: Aflibercept biosimilars demonstrated comparable efficacy and safety profiles to reference aflibercept in the treatment of nAMD. These findings suggest that biosimilars may serve as a cost-effective alternative without compromising patient outcomes.Keywords: neovascular age-related macular degeneration, nAMD, aflibercept, biosimilars, anti-VEGF therapy, efficacy, safetyhttps://www.dovepress.com/efficacy-and-safety-of-aflibercept-biosimilars-relative-to-reference-a-peer-reviewed-fulltext-article-OPTHNeovascular age-related macular degenerationnAMDafliberceptbiosimilarsanti-VEGF therapyefficacy |
| spellingShingle | Aljuhani HS Hubayni RA Qedair J Bukhari ZM Alzahrani A Bawazir RO Badghaish OS Alqahtani F Efficacy and Safety of Aflibercept Biosimilars Relative to Reference Aflibercept Therapy for Neovascular Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis Clinical Ophthalmology Neovascular age-related macular degeneration nAMD aflibercept biosimilars anti-VEGF therapy efficacy |
| title | Efficacy and Safety of Aflibercept Biosimilars Relative to Reference Aflibercept Therapy for Neovascular Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis |
| title_full | Efficacy and Safety of Aflibercept Biosimilars Relative to Reference Aflibercept Therapy for Neovascular Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis |
| title_fullStr | Efficacy and Safety of Aflibercept Biosimilars Relative to Reference Aflibercept Therapy for Neovascular Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Efficacy and Safety of Aflibercept Biosimilars Relative to Reference Aflibercept Therapy for Neovascular Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis |
| title_short | Efficacy and Safety of Aflibercept Biosimilars Relative to Reference Aflibercept Therapy for Neovascular Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis |
| title_sort | efficacy and safety of aflibercept biosimilars relative to reference aflibercept therapy for neovascular age related macular degeneration a systematic review and meta analysis |
| topic | Neovascular age-related macular degeneration nAMD aflibercept biosimilars anti-VEGF therapy efficacy |
| url | https://www.dovepress.com/efficacy-and-safety-of-aflibercept-biosimilars-relative-to-reference-a-peer-reviewed-fulltext-article-OPTH |
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