Synthesis and antimicrobial activity of new betulin derivatives
Abstract The overuse and often unjustified application of antibiotics have led to the emergence of drug-resistant bacterial strains, posing a serious threat to public health. This escalating issue underscores the urgent need to discover new antibiotics and explore novel targets for antibacterial the...
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Nature Portfolio
2025-05-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-02769-3 |
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| author | Agata Serrafi Andrzej Wasilewski |
| author_facet | Agata Serrafi Andrzej Wasilewski |
| author_sort | Agata Serrafi |
| collection | DOAJ |
| description | Abstract The overuse and often unjustified application of antibiotics have led to the emergence of drug-resistant bacterial strains, posing a serious threat to public health. This escalating issue underscores the urgent need to discover new antibiotics and explore novel targets for antibacterial therapies. Betulin, a naturally occurring triterpene found abundantly in white birch bark, has attracted attention due to its broad spectrum of biological activities, even at low concentrations. In this study, we synthesized a novel derivative of betulin and evaluated its antibacterial efficacy against various pathogenic bacterial strains. The betulin derivative demonstrated inhibitory effects on the growth of Staphylococcus aureus, and its Minimum Inhibitory Concentration (MIC) was determined. These findings suggest that betulin derivatives hold promise as potential candidates in the fight against antibiotic-resistant infections. |
| format | Article |
| id | doaj-art-862f5110f3c04a3ca70a9407e2e9fb81 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-862f5110f3c04a3ca70a9407e2e9fb812025-08-20T03:48:18ZengNature PortfolioScientific Reports2045-23222025-05-011511810.1038/s41598-025-02769-3Synthesis and antimicrobial activity of new betulin derivativesAgata Serrafi0Andrzej Wasilewski1Department of Immunochemistry and Chemistry, Wroclaw Medical UniversityStudent Scientific Association of Medical Chemistry and Immunochemistry, Wroclaw Medical UniversityAbstract The overuse and often unjustified application of antibiotics have led to the emergence of drug-resistant bacterial strains, posing a serious threat to public health. This escalating issue underscores the urgent need to discover new antibiotics and explore novel targets for antibacterial therapies. Betulin, a naturally occurring triterpene found abundantly in white birch bark, has attracted attention due to its broad spectrum of biological activities, even at low concentrations. In this study, we synthesized a novel derivative of betulin and evaluated its antibacterial efficacy against various pathogenic bacterial strains. The betulin derivative demonstrated inhibitory effects on the growth of Staphylococcus aureus, and its Minimum Inhibitory Concentration (MIC) was determined. These findings suggest that betulin derivatives hold promise as potential candidates in the fight against antibiotic-resistant infections.https://doi.org/10.1038/s41598-025-02769-3BetulinSynthesisAntibacterial activityBacteriostatic activity |
| spellingShingle | Agata Serrafi Andrzej Wasilewski Synthesis and antimicrobial activity of new betulin derivatives Scientific Reports Betulin Synthesis Antibacterial activity Bacteriostatic activity |
| title | Synthesis and antimicrobial activity of new betulin derivatives |
| title_full | Synthesis and antimicrobial activity of new betulin derivatives |
| title_fullStr | Synthesis and antimicrobial activity of new betulin derivatives |
| title_full_unstemmed | Synthesis and antimicrobial activity of new betulin derivatives |
| title_short | Synthesis and antimicrobial activity of new betulin derivatives |
| title_sort | synthesis and antimicrobial activity of new betulin derivatives |
| topic | Betulin Synthesis Antibacterial activity Bacteriostatic activity |
| url | https://doi.org/10.1038/s41598-025-02769-3 |
| work_keys_str_mv | AT agataserrafi synthesisandantimicrobialactivityofnewbetulinderivatives AT andrzejwasilewski synthesisandantimicrobialactivityofnewbetulinderivatives |