Retrospective Assessment of Secondary Bacterial and Fungal Infections in COVID-19 Patients at a Tertiary Care Hospital in Navi Mumbai
Introduction: Secondary bacterial and fungal infections are a significant concern in COVID-19 patients, particularly those critically ill and requiring intensive care. This retrospective study investigated the prevalence and spectrum of secondary infections among COVID-19 patients admitted to the...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Pasteur Institute of Iran
2024-03-01
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| Series: | Journal of Medical Microbiology and Infectious Diseases |
| Subjects: | |
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| Summary: | Introduction: Secondary bacterial and fungal infections are a significant
concern in COVID-19 patients, particularly those critically ill and requiring
intensive care. This retrospective study investigated the prevalence and
spectrum of secondary infections among COVID-19 patients admitted to the
intensive care unit (ICU) at a tertiary care hospital in Navi Mumbai.
Additionally, we explored the association between secondary infections and
patient comorbidities. Methods: We performed a single-center,
retrospective cohort study of 3234 COVID-19 patients admitted to a tertiary
care hospital in Navi Mumbai, India, between August 2020 and August
2021. Microbiological data from various clinical specimens, including
blood, sputum, bronchoalveolar lavage (BAL) fluid, urine, and tissue
cultures, were retrospectively analyzed. Patient demographics and
comorbidities were extracted from medical records. We employed
descriptive statistics and Pearson's Chi-square test for data analysis to
identify associations between secondary infections and patient
characteristics. Results: Among the 3234 COVID-19 patients, 195 (6.02%)
presented with clinical features suggestive of secondary infections.
Microbiological analysis confirmed secondary infections in 98 patients
(3.03%), with a culture positivity rate of 50.3%. Among bacterial isolates,
Klebsiella pneumoniae was the most prevalent (43.28%), followed by
Acinetobacter baumannii (25.37%). Aspergillus spp. emerged as the
dominant fungal pathogen. Notably, Escherichia coli isolation was
significantly associated with various specimen types (P < 0.001). However,
no significant correlation was found between secondary infection rates and
patient comorbidities. Conclusion: Gram-negative bacteria, specifically K.
pneumoniae and A. baumannii, were the primary pathogens responsible for
secondary infections in our cohort of critically ill COVID-19 patients
admitted to the ICU. These findings underscore the importance of ongoing
surveillance and monitoring of secondary infection trends, including fungal
pathogens, to inform and optimize management strategies in this high-risk
population. |
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| ISSN: | 2345-5349 2345-5330 |