A dosimetric evaluation using the Monte Carlo method considering geometric variations of the Iodine-125 seed for brachytherapy
The Institute for Energy and Nuclear Research – IPEN-CNEN/SP is uniquely positioned to develop a new source of Iodine-125 for brachytherapy treatment. Therefore, research into the dosimetric process and source design is widely studied. Task Group 43 – TG 43 cites methodologies for dosimetry of sourc...
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Brazilian Radiation Protection Society (Sociedade Brasileira de Proteção Radiológica, SBPR)
2025-02-01
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| Series: | Brazilian Journal of Radiation Sciences |
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| Online Access: | https://bjrs.org.br/revista/index.php/REVISTA/article/view/2543 |
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| author | Henrique Santos de Chico Lucas Verdi Angelocci Carlos Alberto Zeituni Carla Daruich de Souza Sabrina Spigaroli Sgrignoli Maria Elisa Chuery Martins Rostelato |
| author_facet | Henrique Santos de Chico Lucas Verdi Angelocci Carlos Alberto Zeituni Carla Daruich de Souza Sabrina Spigaroli Sgrignoli Maria Elisa Chuery Martins Rostelato |
| author_sort | Henrique Santos de Chico |
| collection | DOAJ |
| description | The Institute for Energy and Nuclear Research – IPEN-CNEN/SP is uniquely positioned to develop a new source of Iodine-125 for brachytherapy treatment. Therefore, research into the dosimetric process and source design is widely studied. Task Group 43 – TG 43 cites methodologies for dosimetry of sources for brachytherapy, the most used method is Monte Carlo. However, the dosimetric protocol does not mention possible variations in the source geometry after its conception. The investigative focus of the work was to obtain measurements of the Iodine-125 seed during the production stages until completion, quantify them and simulate them using the Monte Carlo method with the MCNP – 4C code, the formalism was in water and a 101x101 matrix was used to calculate the dose point by point. Two variations were chosen: a) seed length; b) nucleus length, using a batch of 100 seeds for each case. 100 simulations were carried out for each variation and one simulation using the reference seed geometry. The following calculations were applied: relative difference to compare variations to the reference; average among the 100 seeds of each batch to calculate the standard deviation. In both cases there was no point that exceeded 4.48% relative difference, and for standard deviation the largest point was 1.6%, while the Type A uncertainty was 0.018% at the largest point.
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| format | Article |
| id | doaj-art-862b637473814f238d6cd042ecdfdda5 |
| institution | DOAJ |
| issn | 2319-0612 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Brazilian Radiation Protection Society (Sociedade Brasileira de Proteção Radiológica, SBPR) |
| record_format | Article |
| series | Brazilian Journal of Radiation Sciences |
| spelling | doaj-art-862b637473814f238d6cd042ecdfdda52025-08-20T03:12:32ZengBrazilian Radiation Protection Society (Sociedade Brasileira de Proteção Radiológica, SBPR)Brazilian Journal of Radiation Sciences2319-06122025-02-01124A (Suppl.)10.15392/2319-0612.2024.25432168A dosimetric evaluation using the Monte Carlo method considering geometric variations of the Iodine-125 seed for brachytherapyHenrique Santos de Chico0https://orcid.org/0009-0004-9335-3207Lucas Verdi Angelocci1https://orcid.org/0000-0003-1439-3952Carlos Alberto Zeituni2https://orcid.org/0000-0002-7303-6720Carla Daruich de Souza3https://orcid.org/0000-0003-1335-8864Sabrina Spigaroli Sgrignoli4https://orcid.org/0009-0009-7288-9201Maria Elisa Chuery Martins Rostelato5https://orcid.org/0000-0003-2943-6097Instituto de Pesquisas Energéticas e NuclearesInstituto de Pesquisas Energéticas e NuclearesInstituto de Pesquisas Energéticas e NuclearesInstituto de Pesquisas Energéticas e NuclearesInstituto de Pesquisas Energéticas e NuclearesInstituto de Pesquisas Energéticas e NuclearesThe Institute for Energy and Nuclear Research – IPEN-CNEN/SP is uniquely positioned to develop a new source of Iodine-125 for brachytherapy treatment. Therefore, research into the dosimetric process and source design is widely studied. Task Group 43 – TG 43 cites methodologies for dosimetry of sources for brachytherapy, the most used method is Monte Carlo. However, the dosimetric protocol does not mention possible variations in the source geometry after its conception. The investigative focus of the work was to obtain measurements of the Iodine-125 seed during the production stages until completion, quantify them and simulate them using the Monte Carlo method with the MCNP – 4C code, the formalism was in water and a 101x101 matrix was used to calculate the dose point by point. Two variations were chosen: a) seed length; b) nucleus length, using a batch of 100 seeds for each case. 100 simulations were carried out for each variation and one simulation using the reference seed geometry. The following calculations were applied: relative difference to compare variations to the reference; average among the 100 seeds of each batch to calculate the standard deviation. In both cases there was no point that exceeded 4.48% relative difference, and for standard deviation the largest point was 1.6%, while the Type A uncertainty was 0.018% at the largest point. https://bjrs.org.br/revista/index.php/REVISTA/article/view/2543RadiotherapyBrachytherapyDosimetryRadiation |
| spellingShingle | Henrique Santos de Chico Lucas Verdi Angelocci Carlos Alberto Zeituni Carla Daruich de Souza Sabrina Spigaroli Sgrignoli Maria Elisa Chuery Martins Rostelato A dosimetric evaluation using the Monte Carlo method considering geometric variations of the Iodine-125 seed for brachytherapy Brazilian Journal of Radiation Sciences Radiotherapy Brachytherapy Dosimetry Radiation |
| title | A dosimetric evaluation using the Monte Carlo method considering geometric variations of the Iodine-125 seed for brachytherapy |
| title_full | A dosimetric evaluation using the Monte Carlo method considering geometric variations of the Iodine-125 seed for brachytherapy |
| title_fullStr | A dosimetric evaluation using the Monte Carlo method considering geometric variations of the Iodine-125 seed for brachytherapy |
| title_full_unstemmed | A dosimetric evaluation using the Monte Carlo method considering geometric variations of the Iodine-125 seed for brachytherapy |
| title_short | A dosimetric evaluation using the Monte Carlo method considering geometric variations of the Iodine-125 seed for brachytherapy |
| title_sort | dosimetric evaluation using the monte carlo method considering geometric variations of the iodine 125 seed for brachytherapy |
| topic | Radiotherapy Brachytherapy Dosimetry Radiation |
| url | https://bjrs.org.br/revista/index.php/REVISTA/article/view/2543 |
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