The role of cerebrovascular reactivity on brain activation during a working memory task in type 2 diabetes
Abstract INTRODUCTION Impaired cerebrovascular reactivity (CVR) is common in type 2 diabetes (T2D) patients and is a risk factor for dementia. However, most prior functional magnetic resonance imaging (fMRI) studies in T2D disregarded the impact of impaired CVR on brain activation patterns. This stu...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
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| Online Access: | https://doi.org/10.1002/dad2.70045 |
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| author | Yarden Oliel Ramit Ravona‐Springer Maayan Harel Joseph Azuri Chen Botvin Moshe David Tanne Salo Haratz Barbara B Bendlin Michal Schnaider Beeri Abigail Livny |
| author_facet | Yarden Oliel Ramit Ravona‐Springer Maayan Harel Joseph Azuri Chen Botvin Moshe David Tanne Salo Haratz Barbara B Bendlin Michal Schnaider Beeri Abigail Livny |
| author_sort | Yarden Oliel |
| collection | DOAJ |
| description | Abstract INTRODUCTION Impaired cerebrovascular reactivity (CVR) is common in type 2 diabetes (T2D) patients and is a risk factor for dementia. However, most prior functional magnetic resonance imaging (fMRI) studies in T2D disregarded the impact of impaired CVR on brain activation patterns. This study investigated the relationship between CVR and brain activation during an fMRI task in T2D patients. METHODS Seventy‐four T2D patients underwent a working‐memory (WM) fMRI task. CVR was measured by the breath‐holding index test using transcranial Doppler (TCD). Regression analyses examined associations between CVR and brain activation and between glycated hemoglobin (HbA1c) and activation with/without adjusting for CVR. RESULTS An association between CVR and brain activation was found in the left middle and inferior frontal gyri. Adjusting for CVR led to a different pattern of HbA1c‐related activation. DISCUSSION The findings highlight methodological implications, emphasizing the importance of accounting for impaired CVR when analyzing and interpreting fMRI data in T2D patients. Highlights The study found that cerebrovascular reactivity impacts brain activation patterns during a working memory task in type 2 diabetes patients. Accounting for cerebrovascular reactivity altered the brain regions showing activation related to working memory and glycemic control. The findings highlight the importance of considering vascular factors when interpreting fMRI data in populations with vascular dysfunction. |
| format | Article |
| id | doaj-art-86232de3df6a4d2b969d77694a3500f2 |
| institution | Kabale University |
| issn | 2352-8729 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| spelling | doaj-art-86232de3df6a4d2b969d77694a3500f22025-08-20T03:42:18ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292025-01-01171n/an/a10.1002/dad2.70045The role of cerebrovascular reactivity on brain activation during a working memory task in type 2 diabetesYarden Oliel0Ramit Ravona‐Springer1Maayan Harel2Joseph Azuri3Chen Botvin Moshe4David Tanne5Salo Haratz6Barbara B Bendlin7Michal Schnaider Beeri8Abigail Livny9Division of Diagnostic Imaging Sheba Medical Center Ramat Gan IsraelThe Joseph Sagol Neuroscience Center Sheba Medical Center Ramat Gan IsraelDivision of Diagnostic Imaging Sheba Medical Center Ramat Gan IsraelFaculty of Medical & Health Sciences Tel‐Aviv University Tel Aviv‐Yafo IsraelThe Joseph Sagol Neuroscience Center Sheba Medical Center Ramat Gan IsraelStroke and Cognition Institute Rambam Health Care Campus Haifa IsraelSamson Assuta Ashdod University Hospital Ashdod IsraelWisconsin Alzheimer's Disease Research Center School of Medicine and Public Health University of Wisconsin‐Madison Madison Wisconsin USAKrieger Klein Alzheimer's Research Center Brain Health Institute Rutgers University Piscataway New Jersey USADivision of Diagnostic Imaging Sheba Medical Center Ramat Gan IsraelAbstract INTRODUCTION Impaired cerebrovascular reactivity (CVR) is common in type 2 diabetes (T2D) patients and is a risk factor for dementia. However, most prior functional magnetic resonance imaging (fMRI) studies in T2D disregarded the impact of impaired CVR on brain activation patterns. This study investigated the relationship between CVR and brain activation during an fMRI task in T2D patients. METHODS Seventy‐four T2D patients underwent a working‐memory (WM) fMRI task. CVR was measured by the breath‐holding index test using transcranial Doppler (TCD). Regression analyses examined associations between CVR and brain activation and between glycated hemoglobin (HbA1c) and activation with/without adjusting for CVR. RESULTS An association between CVR and brain activation was found in the left middle and inferior frontal gyri. Adjusting for CVR led to a different pattern of HbA1c‐related activation. DISCUSSION The findings highlight methodological implications, emphasizing the importance of accounting for impaired CVR when analyzing and interpreting fMRI data in T2D patients. Highlights The study found that cerebrovascular reactivity impacts brain activation patterns during a working memory task in type 2 diabetes patients. Accounting for cerebrovascular reactivity altered the brain regions showing activation related to working memory and glycemic control. The findings highlight the importance of considering vascular factors when interpreting fMRI data in populations with vascular dysfunction.https://doi.org/10.1002/dad2.70045Alzheimer's diseasebraincerebrovascular reactivityfMRItype‐2 diabetesworking memory |
| spellingShingle | Yarden Oliel Ramit Ravona‐Springer Maayan Harel Joseph Azuri Chen Botvin Moshe David Tanne Salo Haratz Barbara B Bendlin Michal Schnaider Beeri Abigail Livny The role of cerebrovascular reactivity on brain activation during a working memory task in type 2 diabetes Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring Alzheimer's disease brain cerebrovascular reactivity fMRI type‐2 diabetes working memory |
| title | The role of cerebrovascular reactivity on brain activation during a working memory task in type 2 diabetes |
| title_full | The role of cerebrovascular reactivity on brain activation during a working memory task in type 2 diabetes |
| title_fullStr | The role of cerebrovascular reactivity on brain activation during a working memory task in type 2 diabetes |
| title_full_unstemmed | The role of cerebrovascular reactivity on brain activation during a working memory task in type 2 diabetes |
| title_short | The role of cerebrovascular reactivity on brain activation during a working memory task in type 2 diabetes |
| title_sort | role of cerebrovascular reactivity on brain activation during a working memory task in type 2 diabetes |
| topic | Alzheimer's disease brain cerebrovascular reactivity fMRI type‐2 diabetes working memory |
| url | https://doi.org/10.1002/dad2.70045 |
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