Antioxidant Naturally Occurring Pleiotropically Acting Bioactive Compounds, as Polymeric Nanotherapeutics Against Autoimmune Diseases Progression
Autoimmune diseases are driven by chronic inflammation and oxidative stress, thus requiring innovative therapeutic approaches. Polymeric nanotherapeutics incorporating antioxidant bioactive compounds offer a promising strategy for immune modulation and enhanced drug delivery. This review explores th...
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2025-06-01
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| author | Panagiotis Theodosis-Nobelos Fani-Niki Varra Michail Varras Georgios Papagiouvannis Eleni A. Rekka |
| author_facet | Panagiotis Theodosis-Nobelos Fani-Niki Varra Michail Varras Georgios Papagiouvannis Eleni A. Rekka |
| author_sort | Panagiotis Theodosis-Nobelos |
| collection | DOAJ |
| description | Autoimmune diseases are driven by chronic inflammation and oxidative stress, thus requiring innovative therapeutic approaches. Polymeric nanotherapeutics incorporating antioxidant bioactive compounds offer a promising strategy for immune modulation and enhanced drug delivery. This review explores the application of polymer-based nanocarriers for improving the solubility, bioavailability, and targeted delivery of antioxidant compounds in autoimmune disease treatment. A comprehensive analysis of recent advancements in polymeric nanoformulations, including poly(lactic-co-glycolic acid) (PLGA), polyethylene glycol (PEG), chitosan, and hyaluronic acid, was conducted. The therapeutic efficacy of various antioxidant-loaded nanoparticles has been assessed in both preclinical and clinical studies. Phenolic antioxidants, such as resveratrol, curcumin, quercetin, and epigallocatechin-3-gallate, exhibit potent anti-inflammatory effects; however, their poor solubility limits their clinical application. Nanocarriers such as dendrosomes, tannic acid-based reactive oxygen species (ROS)-scavenging nanoparticles, and folic acid-functionalized systems enhance drug stability, controlled drug release, and macrophage targeting. Carotenoid and bilirubin nanoparticles further demonstrate immunomodulatory effects in multiple sclerosis, psoriasis, rheumatoid arthritis, and inflammatory bowel disease. Polymeric antioxidant nanotherapeutics provide targeted and sustained drug delivery, offering improved efficacy and reduced toxicity. Future research should focus on optimizing these nanocarriers for clinical translation and patient-centered therapeutic strategies. |
| format | Article |
| id | doaj-art-8621faceebb1400eba5aa8b90d484c80 |
| institution | Kabale University |
| issn | 1467-3037 1467-3045 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
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| spelling | doaj-art-8621faceebb1400eba5aa8b90d484c802025-08-20T03:26:11ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452025-06-0147641110.3390/cimb47060411Antioxidant Naturally Occurring Pleiotropically Acting Bioactive Compounds, as Polymeric Nanotherapeutics Against Autoimmune Diseases ProgressionPanagiotis Theodosis-Nobelos0Fani-Niki Varra1Michail Varras2Georgios Papagiouvannis3Eleni A. Rekka4Department of Pharmacy, School of Health Sciences, Frederick University, Nicosia 1036, CyprusMedical School, Democritus University of Thrace, 68100 Alexandroupolis, GreeceFourth Department of Obstetrics and Gynecology, ‘Elena Venizelou’ General Hospital, 11521 Athens, GreeceDepartment of Pharmacy, School of Health Sciences, Frederick University, Nicosia 1036, CyprusDepartment of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceAutoimmune diseases are driven by chronic inflammation and oxidative stress, thus requiring innovative therapeutic approaches. Polymeric nanotherapeutics incorporating antioxidant bioactive compounds offer a promising strategy for immune modulation and enhanced drug delivery. This review explores the application of polymer-based nanocarriers for improving the solubility, bioavailability, and targeted delivery of antioxidant compounds in autoimmune disease treatment. A comprehensive analysis of recent advancements in polymeric nanoformulations, including poly(lactic-co-glycolic acid) (PLGA), polyethylene glycol (PEG), chitosan, and hyaluronic acid, was conducted. The therapeutic efficacy of various antioxidant-loaded nanoparticles has been assessed in both preclinical and clinical studies. Phenolic antioxidants, such as resveratrol, curcumin, quercetin, and epigallocatechin-3-gallate, exhibit potent anti-inflammatory effects; however, their poor solubility limits their clinical application. Nanocarriers such as dendrosomes, tannic acid-based reactive oxygen species (ROS)-scavenging nanoparticles, and folic acid-functionalized systems enhance drug stability, controlled drug release, and macrophage targeting. Carotenoid and bilirubin nanoparticles further demonstrate immunomodulatory effects in multiple sclerosis, psoriasis, rheumatoid arthritis, and inflammatory bowel disease. Polymeric antioxidant nanotherapeutics provide targeted and sustained drug delivery, offering improved efficacy and reduced toxicity. Future research should focus on optimizing these nanocarriers for clinical translation and patient-centered therapeutic strategies.https://www.mdpi.com/1467-3045/47/6/411autoimmune diseaseoxidative stressantioxidant bioactive compoundsinflammationtargeted drug deliverypharmacokinetic improvement |
| spellingShingle | Panagiotis Theodosis-Nobelos Fani-Niki Varra Michail Varras Georgios Papagiouvannis Eleni A. Rekka Antioxidant Naturally Occurring Pleiotropically Acting Bioactive Compounds, as Polymeric Nanotherapeutics Against Autoimmune Diseases Progression Current Issues in Molecular Biology autoimmune disease oxidative stress antioxidant bioactive compounds inflammation targeted drug delivery pharmacokinetic improvement |
| title | Antioxidant Naturally Occurring Pleiotropically Acting Bioactive Compounds, as Polymeric Nanotherapeutics Against Autoimmune Diseases Progression |
| title_full | Antioxidant Naturally Occurring Pleiotropically Acting Bioactive Compounds, as Polymeric Nanotherapeutics Against Autoimmune Diseases Progression |
| title_fullStr | Antioxidant Naturally Occurring Pleiotropically Acting Bioactive Compounds, as Polymeric Nanotherapeutics Against Autoimmune Diseases Progression |
| title_full_unstemmed | Antioxidant Naturally Occurring Pleiotropically Acting Bioactive Compounds, as Polymeric Nanotherapeutics Against Autoimmune Diseases Progression |
| title_short | Antioxidant Naturally Occurring Pleiotropically Acting Bioactive Compounds, as Polymeric Nanotherapeutics Against Autoimmune Diseases Progression |
| title_sort | antioxidant naturally occurring pleiotropically acting bioactive compounds as polymeric nanotherapeutics against autoimmune diseases progression |
| topic | autoimmune disease oxidative stress antioxidant bioactive compounds inflammation targeted drug delivery pharmacokinetic improvement |
| url | https://www.mdpi.com/1467-3045/47/6/411 |
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