Selective Allosteric Inhibition of MMP9 Is Efficacious in Preclinical Models of Ulcerative Colitis and Colorectal Cancer.

Selective Allosteric Inhibition of MMP9 Is Efficacious in Preclinical Models of Ulcerative Colitis and Colorectal Cancer.

Expression of matrix metalloproteinase 9 (MMP9) is elevated in a variety of inflammatory and oncology indications, including ulcerative colitis and colorectal cancer. MMP9 is a downstream effector and an upstream mediator of pathways involved in growth and inflammation, and has long been viewed as a...

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Main Authors: Derek C Marshall, Susan K Lyman, Scott McCauley, Maria Kovalenko, Rhyannon Spangler, Chian Liu, Michael Lee, Christopher O'Sullivan, Vivian Barry-Hamilton, Haben Ghermazien, Amanda Mikels-Vigdal, Carlos A Garcia, Brett Jorgensen, Arleene C Velayo, Ruth Wang, Joanne I Adamkewicz, Victoria Smith
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0127063
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