Synthesis and QSAR Study of Some HDL Cholesterol Increasing Quinazolinone Derivatives
We describe here an easy and efficient method to obtain S-alkylated derivatives of thio-quinazolinone using different alkylating agents via a solvent-free microwave-assisted method. The alkylated thio quinazolinones were further sequentially condensed with hydrazine hydrate and different aromatic al...
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| Format: | Article |
| Language: | English |
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Wiley
2004-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2004/671567 |
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| author | M. B. Deshmukh Savita Dhongade (Desai) |
| author_facet | M. B. Deshmukh Savita Dhongade (Desai) |
| author_sort | M. B. Deshmukh |
| collection | DOAJ |
| description | We describe here an easy and efficient method to obtain S-alkylated derivatives of thio-quinazolinone using different alkylating agents via a solvent-free microwave-assisted method. The alkylated thio quinazolinones were further sequentially condensed with hydrazine hydrate and different aromatic aldehydes to get the hydrazones, which were studied for QSAR. The synthesized compounds were subjected to a prediction of biological activities. A software application (PASS) was used for this purpose. The relationship between structure and different biological activities was studied and the different derivatives were recommended for the screening of some specific activities like anti-tuberculosic, anti-mycobacterial and HDL cholesterol increasing activities. |
| format | Article |
| id | doaj-art-861196be28e84321af4734d8205b2c2a |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2004-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-861196be28e84321af4734d8205b2c2a2025-02-03T01:02:05ZengWileyE-Journal of Chemistry0973-49452090-98102004-01-0111173110.1155/2004/671567Synthesis and QSAR Study of Some HDL Cholesterol Increasing Quinazolinone DerivativesM. B. Deshmukh0Savita Dhongade (Desai)1Department of Chemistry, Shivaji University, Kolhapur-416004, IndiaDepartment of Chemistry, Shivaji University, Kolhapur-416004, IndiaWe describe here an easy and efficient method to obtain S-alkylated derivatives of thio-quinazolinone using different alkylating agents via a solvent-free microwave-assisted method. The alkylated thio quinazolinones were further sequentially condensed with hydrazine hydrate and different aromatic aldehydes to get the hydrazones, which were studied for QSAR. The synthesized compounds were subjected to a prediction of biological activities. A software application (PASS) was used for this purpose. The relationship between structure and different biological activities was studied and the different derivatives were recommended for the screening of some specific activities like anti-tuberculosic, anti-mycobacterial and HDL cholesterol increasing activities.http://dx.doi.org/10.1155/2004/671567 |
| spellingShingle | M. B. Deshmukh Savita Dhongade (Desai) Synthesis and QSAR Study of Some HDL Cholesterol Increasing Quinazolinone Derivatives E-Journal of Chemistry |
| title | Synthesis and QSAR Study of Some HDL Cholesterol Increasing Quinazolinone Derivatives |
| title_full | Synthesis and QSAR Study of Some HDL Cholesterol Increasing Quinazolinone Derivatives |
| title_fullStr | Synthesis and QSAR Study of Some HDL Cholesterol Increasing Quinazolinone Derivatives |
| title_full_unstemmed | Synthesis and QSAR Study of Some HDL Cholesterol Increasing Quinazolinone Derivatives |
| title_short | Synthesis and QSAR Study of Some HDL Cholesterol Increasing Quinazolinone Derivatives |
| title_sort | synthesis and qsar study of some hdl cholesterol increasing quinazolinone derivatives |
| url | http://dx.doi.org/10.1155/2004/671567 |
| work_keys_str_mv | AT mbdeshmukh synthesisandqsarstudyofsomehdlcholesterolincreasingquinazolinonederivatives AT savitadhongadedesai synthesisandqsarstudyofsomehdlcholesterolincreasingquinazolinonederivatives |