Integrated transcriptomic and metabolomic analysis of the antibacterial mechanism of Rhizoma Coptidis extract against Staphylococcus epidermidis ATCC 35984

Integrated transcriptomic and metabolomic analysis of the antibacterial mechanism of Rhizoma Coptidis extract against Staphylococcus epidermidis ATCC 35984

Abstract Background Biofilm formation is a key virulence factor in Staphylococcus epidermidis. Rhizoma Coptidis, the medicinal root of Coptis chinensis, has been traditionally used in Chinese medicine for its broad-spectrum antimicrobial properties. Results This study investigated the antibacterial...

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Bibliographic Details
Main Authors: Lizhuang Wang, Yan Xing, Shuai Yang, Huan Zhang, Laiji Ma, Li Shao
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Microbiology
Subjects:
Rhizoma Coptidis extract
Staphylococcus epidermidis
Antibacterial activity
Biofilm
Transcriptomic
Metabolomic
Online Access:https://doi.org/10.1186/s12866-025-04169-z
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