Genome-Wide Identification and Classification of MicroRNAs Derived from Repetitive Elements
MicroRNAs (miRNAs) are known for their role in mRNA silencing via interference pathways. Repetitive elements (REs) share several characteristics with endogenous precursor miRNAs. In this study, 406 previously identified and 1,494 novel RE-derived miRNAs were sorted from the GENCODE v.19 database usi...
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| Format: | Article |
| Language: | English |
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BioMed Central
2014-12-01
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| Series: | Genomics & Informatics |
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| Online Access: | http://genominfo.org/upload/pdf/gni-12-261.pdf |
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| _version_ | 1832569808604889088 |
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| author | Jeong-An Gim Hong-Seok Ha Kung Ahn Dae-Soo Kim Heui-Soo Kim |
| author_facet | Jeong-An Gim Hong-Seok Ha Kung Ahn Dae-Soo Kim Heui-Soo Kim |
| author_sort | Jeong-An Gim |
| collection | DOAJ |
| description | MicroRNAs (miRNAs) are known for their role in mRNA silencing via interference pathways. Repetitive elements (REs) share several characteristics with endogenous precursor miRNAs. In this study, 406 previously identified and 1,494 novel RE-derived miRNAs were sorted from the GENCODE v.19 database using the RepeatMasker program. They were divided into six major types, based on their genomic structure. More novel RE-derived miRNAs were confirmed than identified as RE-derived miRNAs. In conclusion, many miRNAs have not yet been identified, most of which are derived from REs. |
| format | Article |
| id | doaj-art-860d1cae12fe460ba7ff13d12b2cdd22 |
| institution | Kabale University |
| issn | 1598-866X 2234-0742 |
| language | English |
| publishDate | 2014-12-01 |
| publisher | BioMed Central |
| record_format | Article |
| series | Genomics & Informatics |
| spelling | doaj-art-860d1cae12fe460ba7ff13d12b2cdd222025-02-02T19:52:11ZengBioMed CentralGenomics & Informatics1598-866X2234-07422014-12-0112426126710.5808/GI.2014.12.4.261118Genome-Wide Identification and Classification of MicroRNAs Derived from Repetitive ElementsJeong-An Gim0Hong-Seok Ha1Kung Ahn2Dae-Soo Kim3Heui-Soo Kim4Department of Biological Sciences, College of Natural Sciences, Pusan National University, Busan 609-735, Korea.Department of Genetics, Human Genetics Institute of New Jersey, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.TBI, Theragen BiO Institute, TheragenEtex, Suwon 443-270, Korea.Genome Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 305-806, Korea.Department of Biological Sciences, College of Natural Sciences, Pusan National University, Busan 609-735, Korea.MicroRNAs (miRNAs) are known for their role in mRNA silencing via interference pathways. Repetitive elements (REs) share several characteristics with endogenous precursor miRNAs. In this study, 406 previously identified and 1,494 novel RE-derived miRNAs were sorted from the GENCODE v.19 database using the RepeatMasker program. They were divided into six major types, based on their genomic structure. More novel RE-derived miRNAs were confirmed than identified as RE-derived miRNAs. In conclusion, many miRNAs have not yet been identified, most of which are derived from REs.http://genominfo.org/upload/pdf/gni-12-261.pdfinterspersed repetitive sequencesmicroRNAnovel miRNAspalindromic structure |
| spellingShingle | Jeong-An Gim Hong-Seok Ha Kung Ahn Dae-Soo Kim Heui-Soo Kim Genome-Wide Identification and Classification of MicroRNAs Derived from Repetitive Elements Genomics & Informatics interspersed repetitive sequences microRNA novel miRNAs palindromic structure |
| title | Genome-Wide Identification and Classification of MicroRNAs Derived from Repetitive Elements |
| title_full | Genome-Wide Identification and Classification of MicroRNAs Derived from Repetitive Elements |
| title_fullStr | Genome-Wide Identification and Classification of MicroRNAs Derived from Repetitive Elements |
| title_full_unstemmed | Genome-Wide Identification and Classification of MicroRNAs Derived from Repetitive Elements |
| title_short | Genome-Wide Identification and Classification of MicroRNAs Derived from Repetitive Elements |
| title_sort | genome wide identification and classification of micrornas derived from repetitive elements |
| topic | interspersed repetitive sequences microRNA novel miRNAs palindromic structure |
| url | http://genominfo.org/upload/pdf/gni-12-261.pdf |
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