Biochemistry and Future Perspectives of Antibiotic Resistance: An Eye on Active Natural Products
Antibiotic resistance poses a serious threat to the current healthcare system, negatively impacting the effectiveness of many antimicrobial treatments. The situation is exacerbated by the widespread overuse and abuse of available antibiotics, accelerating the evolution of resistance. Thus, there is...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-11-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/13/11/1071 |
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| author | Giulia Caioni Carolina Pérez Reyes Davide Laurenti Carmen Chiaradia Enrico Dainese Roberto Mattioli Daniel Di Risola Eleonora Santavicca Antonio Francioso |
| author_facet | Giulia Caioni Carolina Pérez Reyes Davide Laurenti Carmen Chiaradia Enrico Dainese Roberto Mattioli Daniel Di Risola Eleonora Santavicca Antonio Francioso |
| author_sort | Giulia Caioni |
| collection | DOAJ |
| description | Antibiotic resistance poses a serious threat to the current healthcare system, negatively impacting the effectiveness of many antimicrobial treatments. The situation is exacerbated by the widespread overuse and abuse of available antibiotics, accelerating the evolution of resistance. Thus, there is an urgent need for novel approaches to therapy to overcome established resistance mechanisms. Plants produce molecules capable of inhibiting bacterial growth in various ways, offering promising paths for the development of alternative antibiotic medicine. This review emphasizes the necessity of research efforts on plant-derived chemicals in the hopes of finding and creating novel drugs that can successfully target resistant bacterial populations. Investigating these natural chemicals allows us to improve our knowledge of novel antimicrobial pathways and also expands our antibacterial repertoire with novel molecules. Simultaneously, it is still necessary to utilize present antibiotics sparingly; prudent prescribing practices must be encouraged to extend the effectiveness of current medications. The combination of innovative drug research and responsible drug usage offers an integrated strategy for managing the antibiotic resistance challenge. |
| format | Article |
| id | doaj-art-86007cd6dd994ba1a61e262de52fbd96 |
| institution | OA Journals |
| issn | 2079-6382 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj-art-86007cd6dd994ba1a61e262de52fbd962025-08-20T01:53:40ZengMDPI AGAntibiotics2079-63822024-11-011311107110.3390/antibiotics13111071Biochemistry and Future Perspectives of Antibiotic Resistance: An Eye on Active Natural ProductsGiulia Caioni0Carolina Pérez Reyes1Davide Laurenti2Carmen Chiaradia3Enrico Dainese4Roberto Mattioli5Daniel Di Risola6Eleonora Santavicca7Antonio Francioso8Department of Bioscience and Technology for Food Agriculture and Environment, University of Teramo, 64100 Teramo, ItalyDepartment of Biochemistry, Microbiology, Cell Biology and Genetics, Instituto Universitario de Bio-Orgánica “Antonio González”, University of La Laguna, 38206 San Cristobal de La Laguna, SpainDepartment of Biochemical Sciences “A. Rossi Fanelli”, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Biochemical Sciences “A. Rossi Fanelli”, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Bioscience and Technology for Food Agriculture and Environment, University of Teramo, 64100 Teramo, ItalyDepartment of Biochemical Sciences “A. Rossi Fanelli”, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Biochemical Sciences “A. Rossi Fanelli”, Sapienza University of Rome, 00185 Rome, ItalyFarmacia D’Onofrio, San Pio delle Camere, 67020 L’Aquila, ItalyDepartment of Bioscience and Technology for Food Agriculture and Environment, University of Teramo, 64100 Teramo, ItalyAntibiotic resistance poses a serious threat to the current healthcare system, negatively impacting the effectiveness of many antimicrobial treatments. The situation is exacerbated by the widespread overuse and abuse of available antibiotics, accelerating the evolution of resistance. Thus, there is an urgent need for novel approaches to therapy to overcome established resistance mechanisms. Plants produce molecules capable of inhibiting bacterial growth in various ways, offering promising paths for the development of alternative antibiotic medicine. This review emphasizes the necessity of research efforts on plant-derived chemicals in the hopes of finding and creating novel drugs that can successfully target resistant bacterial populations. Investigating these natural chemicals allows us to improve our knowledge of novel antimicrobial pathways and also expands our antibacterial repertoire with novel molecules. Simultaneously, it is still necessary to utilize present antibiotics sparingly; prudent prescribing practices must be encouraged to extend the effectiveness of current medications. The combination of innovative drug research and responsible drug usage offers an integrated strategy for managing the antibiotic resistance challenge.https://www.mdpi.com/2079-6382/13/11/1071natural bioactive compoundsantibioticsbiological chemistrypharmacologyphytochemistryantibiotic resistance |
| spellingShingle | Giulia Caioni Carolina Pérez Reyes Davide Laurenti Carmen Chiaradia Enrico Dainese Roberto Mattioli Daniel Di Risola Eleonora Santavicca Antonio Francioso Biochemistry and Future Perspectives of Antibiotic Resistance: An Eye on Active Natural Products Antibiotics natural bioactive compounds antibiotics biological chemistry pharmacology phytochemistry antibiotic resistance |
| title | Biochemistry and Future Perspectives of Antibiotic Resistance: An Eye on Active Natural Products |
| title_full | Biochemistry and Future Perspectives of Antibiotic Resistance: An Eye on Active Natural Products |
| title_fullStr | Biochemistry and Future Perspectives of Antibiotic Resistance: An Eye on Active Natural Products |
| title_full_unstemmed | Biochemistry and Future Perspectives of Antibiotic Resistance: An Eye on Active Natural Products |
| title_short | Biochemistry and Future Perspectives of Antibiotic Resistance: An Eye on Active Natural Products |
| title_sort | biochemistry and future perspectives of antibiotic resistance an eye on active natural products |
| topic | natural bioactive compounds antibiotics biological chemistry pharmacology phytochemistry antibiotic resistance |
| url | https://www.mdpi.com/2079-6382/13/11/1071 |
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