A glaucoma micro-stent with diverging channel and stepped shaft structure based on microfluidic template processing technology
Abstract Background Minimally invasive glaucoma surgery (MIGS) has experienced a surge in popularity in recent years. Glaucoma micro-stents serve as the foundation for these minimally invasive procedures. Nevertheless, the utilization of these stents still presents certain short-term and long-term c...
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| Format: | Article |
| Language: | English |
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BMC
2024-07-01
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| Series: | BioMedical Engineering OnLine |
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| Online Access: | https://doi.org/10.1186/s12938-024-01266-4 |
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| author | Chen Wang Fule Wang Yunru Liao Chengguo Zuo Mingkai Lin Kemin Wang Dongni Ren Hongbo Zhang Ruixue Yin |
| author_facet | Chen Wang Fule Wang Yunru Liao Chengguo Zuo Mingkai Lin Kemin Wang Dongni Ren Hongbo Zhang Ruixue Yin |
| author_sort | Chen Wang |
| collection | DOAJ |
| description | Abstract Background Minimally invasive glaucoma surgery (MIGS) has experienced a surge in popularity in recent years. Glaucoma micro-stents serve as the foundation for these minimally invasive procedures. Nevertheless, the utilization of these stents still presents certain short-term and long-term complications. This study aims to elucidate the creation of a novel drainage stent implant featuring a diverging channel, produced through microfluidic template processing technology. Additionally, an analysis of the mechanical properties, biocompatibility, and feasibility of implantation is conducted. Results The stress concentration value of the proposed stent is significantly lower, approximately two to three times smaller, compared to the currently available commercial XEN gel stent. This indicates a stronger resistance to bending in theory. Theoretical calculations further reveal that the initial drainage efficiency of the gradient diverging drainage stent is approximately 5.76 times higher than that of XEN stents. Notably, in vivo experiments conducted at the third month demonstrate a favorable biocompatibility profile without any observed cytotoxicity. Additionally, the drainage stent exhibits excellent material stability in an in vitro simulation environment. Conclusions In summary, the diverging drainage stent presents a novel approach to the cost-effective and efficient preparation process of minimally invasive glaucoma surgery (MIGS) devices, offering additional filtering treatment options for glaucoma. |
| format | Article |
| id | doaj-art-85fe55f02703412792ebc6dd9d443d79 |
| institution | DOAJ |
| issn | 1475-925X |
| language | English |
| publishDate | 2024-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BioMedical Engineering OnLine |
| spelling | doaj-art-85fe55f02703412792ebc6dd9d443d792025-08-20T03:05:46ZengBMCBioMedical Engineering OnLine1475-925X2024-07-0123112210.1186/s12938-024-01266-4A glaucoma micro-stent with diverging channel and stepped shaft structure based on microfluidic template processing technologyChen Wang0Fule Wang1Yunru Liao2Chengguo Zuo3Mingkai Lin4Kemin Wang5Dongni Ren6Hongbo Zhang7Ruixue Yin8School of Mechanical and Power Engineering, East China University of Science and TechnologySchool of Mechanical and Power Engineering, East China University of Science and TechnologyState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen UniversityState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen UniversityState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen UniversityMingche Biotechnology Co., LtdMingche Biotechnology Co., LtdSchool of Mechanical and Power Engineering, East China University of Science and TechnologySchool of Mechanical and Power Engineering, East China University of Science and TechnologyAbstract Background Minimally invasive glaucoma surgery (MIGS) has experienced a surge in popularity in recent years. Glaucoma micro-stents serve as the foundation for these minimally invasive procedures. Nevertheless, the utilization of these stents still presents certain short-term and long-term complications. This study aims to elucidate the creation of a novel drainage stent implant featuring a diverging channel, produced through microfluidic template processing technology. Additionally, an analysis of the mechanical properties, biocompatibility, and feasibility of implantation is conducted. Results The stress concentration value of the proposed stent is significantly lower, approximately two to three times smaller, compared to the currently available commercial XEN gel stent. This indicates a stronger resistance to bending in theory. Theoretical calculations further reveal that the initial drainage efficiency of the gradient diverging drainage stent is approximately 5.76 times higher than that of XEN stents. Notably, in vivo experiments conducted at the third month demonstrate a favorable biocompatibility profile without any observed cytotoxicity. Additionally, the drainage stent exhibits excellent material stability in an in vitro simulation environment. Conclusions In summary, the diverging drainage stent presents a novel approach to the cost-effective and efficient preparation process of minimally invasive glaucoma surgery (MIGS) devices, offering additional filtering treatment options for glaucoma.https://doi.org/10.1186/s12938-024-01266-4GlaucomaMIGSDrainage stentMicrofluidic channel processingPDMSDrainage efficiency |
| spellingShingle | Chen Wang Fule Wang Yunru Liao Chengguo Zuo Mingkai Lin Kemin Wang Dongni Ren Hongbo Zhang Ruixue Yin A glaucoma micro-stent with diverging channel and stepped shaft structure based on microfluidic template processing technology BioMedical Engineering OnLine Glaucoma MIGS Drainage stent Microfluidic channel processing PDMS Drainage efficiency |
| title | A glaucoma micro-stent with diverging channel and stepped shaft structure based on microfluidic template processing technology |
| title_full | A glaucoma micro-stent with diverging channel and stepped shaft structure based on microfluidic template processing technology |
| title_fullStr | A glaucoma micro-stent with diverging channel and stepped shaft structure based on microfluidic template processing technology |
| title_full_unstemmed | A glaucoma micro-stent with diverging channel and stepped shaft structure based on microfluidic template processing technology |
| title_short | A glaucoma micro-stent with diverging channel and stepped shaft structure based on microfluidic template processing technology |
| title_sort | glaucoma micro stent with diverging channel and stepped shaft structure based on microfluidic template processing technology |
| topic | Glaucoma MIGS Drainage stent Microfluidic channel processing PDMS Drainage efficiency |
| url | https://doi.org/10.1186/s12938-024-01266-4 |
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