Innovative nanocarriers: Synthetic and biomimetic strategies for enhanced drug delivery
Effective drug delivery plays a vital role in the treatment of various biomedical conditions. Application of innovative nanocarriers could address issues faced in drug delivery such as poor drug distribution, inefficient penetration across biological barriers, targeting and security. With the develo...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-10-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425007501 |
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| author | Runzi Guo Zhenzhen Zhang Shuyi Zhang Tingting Gai Huizhu Yu Li Su Heng Yin Xiuhui Wang Yafeng Zhang |
| author_facet | Runzi Guo Zhenzhen Zhang Shuyi Zhang Tingting Gai Huizhu Yu Li Su Heng Yin Xiuhui Wang Yafeng Zhang |
| author_sort | Runzi Guo |
| collection | DOAJ |
| description | Effective drug delivery plays a vital role in the treatment of various biomedical conditions. Application of innovative nanocarriers could address issues faced in drug delivery such as poor drug distribution, inefficient penetration across biological barriers, targeting and security. With the development of nanotechnology, the preparation approaches, structures and properties of nanocarriers are continuously improving, while the comparison of detailed construction strategies and corresponding innovative application of different nanocarriers for enhanced drug delivery are few. In this review, innovative nanocarriers including synthetic nanocarriers with different shapes and biomimetic nanocarriers inspired by different biological sources are introduced. Moreover, the multi-functionalities and advancements of nanocarriers in drug delivery are intensively discussed. Finally, we outline the current limitations and future perspectives of nanocarriers efforts in drug delivery, with a focus on their key challenges from bench to bedside. |
| format | Article |
| id | doaj-art-85fd74a6a97f4c4aa8dc162ff4df9b02 |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-85fd74a6a97f4c4aa8dc162ff4df9b022025-08-20T03:36:40ZengElsevierMaterials Today Bio2590-00642025-10-013410218010.1016/j.mtbio.2025.102180Innovative nanocarriers: Synthetic and biomimetic strategies for enhanced drug deliveryRunzi Guo0Zhenzhen Zhang1Shuyi Zhang2Tingting Gai3Huizhu Yu4Li Su5Heng Yin6Xiuhui Wang7Yafeng Zhang8Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China; Organoid Research Center, Shanghai University, Shanghai, 200444, China; School of Medicine, Shanghai University, Shanghai, 200444, ChinaInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, China; Organoid Research Center, Shanghai University, Shanghai, 200444, China; School of Medicine, Shanghai University, Shanghai, 200444, ChinaInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, China; Organoid Research Center, Shanghai University, Shanghai, 200444, China; School of Medicine, Shanghai University, Shanghai, 200444, ChinaInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, China; Organoid Research Center, Shanghai University, Shanghai, 200444, China; School of Medicine, Shanghai University, Shanghai, 200444, ChinaSchool of Chemistry & Materials Engineering, Fuyang Normal University, Fuyang, 236037, ChinaInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, China; Organoid Research Center, Shanghai University, Shanghai, 200444, ChinaJiangsu CM Clinical Innovation Center of Degenerative Bone & Joint Disease, Wuxi TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Wuxi, 214071, China; Corresponding author. Jiangsu CM Clinical Innovation Center of Degenerative Bone & Joint Disease, Wuxi TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Wuxi, 214071, China.Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China; Organoid Research Center, Shanghai University, Shanghai, 200444, China; Corresponding author. Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China.Jiangsu CM Clinical Innovation Center of Degenerative Bone & Joint Disease, Wuxi TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Wuxi, 214071, China; Corresponding author. Jiangsu CM Clinical Innovation Center of Degenerative Bone & Joint Disease, Wuxi TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Wuxi, 214071, China.Effective drug delivery plays a vital role in the treatment of various biomedical conditions. Application of innovative nanocarriers could address issues faced in drug delivery such as poor drug distribution, inefficient penetration across biological barriers, targeting and security. With the development of nanotechnology, the preparation approaches, structures and properties of nanocarriers are continuously improving, while the comparison of detailed construction strategies and corresponding innovative application of different nanocarriers for enhanced drug delivery are few. In this review, innovative nanocarriers including synthetic nanocarriers with different shapes and biomimetic nanocarriers inspired by different biological sources are introduced. Moreover, the multi-functionalities and advancements of nanocarriers in drug delivery are intensively discussed. Finally, we outline the current limitations and future perspectives of nanocarriers efforts in drug delivery, with a focus on their key challenges from bench to bedside.http://www.sciencedirect.com/science/article/pii/S2590006425007501Synthetic nanocarriersBiomimetic nanocarriersVarious shapesMultifuctionalitiesDrug deliveryDisease treatments |
| spellingShingle | Runzi Guo Zhenzhen Zhang Shuyi Zhang Tingting Gai Huizhu Yu Li Su Heng Yin Xiuhui Wang Yafeng Zhang Innovative nanocarriers: Synthetic and biomimetic strategies for enhanced drug delivery Materials Today Bio Synthetic nanocarriers Biomimetic nanocarriers Various shapes Multifuctionalities Drug delivery Disease treatments |
| title | Innovative nanocarriers: Synthetic and biomimetic strategies for enhanced drug delivery |
| title_full | Innovative nanocarriers: Synthetic and biomimetic strategies for enhanced drug delivery |
| title_fullStr | Innovative nanocarriers: Synthetic and biomimetic strategies for enhanced drug delivery |
| title_full_unstemmed | Innovative nanocarriers: Synthetic and biomimetic strategies for enhanced drug delivery |
| title_short | Innovative nanocarriers: Synthetic and biomimetic strategies for enhanced drug delivery |
| title_sort | innovative nanocarriers synthetic and biomimetic strategies for enhanced drug delivery |
| topic | Synthetic nanocarriers Biomimetic nanocarriers Various shapes Multifuctionalities Drug delivery Disease treatments |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425007501 |
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