Wharton’s Jelly Bioscaffolds Improve Cardiac Repair with Bone Marrow Mononuclear Stem Cells in Rats
This study assessed the impact of implanting mononuclear stem cells and Wharton’s Jelly (WJ), either separately or together, on left ventricular dysfunction following myocardial infarction in Wistar rats. Functional and histopathological parameters were analyzed, and a rat model of left anterior des...
Saved in:
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-05-01
|
| Series: | Journal of Functional Biomaterials |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-4983/16/5/175 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849327164634169344 |
|---|---|
| author | Luize Kremer Gamba Laiza Kremer Gamba Camila da Costa Aline Luri Takejima Rossana Baggio Simeoni Isabella Cristina Mendes Rossa Anna Clara Faidiga Silva Julia Letícia de Bortolo Marcos Antônio Denk Seigo Nagashima Carlos de Almeida Barbosa Paulo Cesar Lock Silveira Júlio César Francisco Luiz César Guarita-Souza |
| author_facet | Luize Kremer Gamba Laiza Kremer Gamba Camila da Costa Aline Luri Takejima Rossana Baggio Simeoni Isabella Cristina Mendes Rossa Anna Clara Faidiga Silva Julia Letícia de Bortolo Marcos Antônio Denk Seigo Nagashima Carlos de Almeida Barbosa Paulo Cesar Lock Silveira Júlio César Francisco Luiz César Guarita-Souza |
| author_sort | Luize Kremer Gamba |
| collection | DOAJ |
| description | This study assessed the impact of implanting mononuclear stem cells and Wharton’s Jelly (WJ), either separately or together, on left ventricular dysfunction following myocardial infarction in Wistar rats. Functional and histopathological parameters were analyzed, and a rat model of left anterior descending coronary artery ligation was used. Treatments included an intramyocardial injection of 0.9% sodium chloride (control, <i>n</i> = 14), decellularized WJ (<i>n</i> = 12), bone marrow-derived mononuclear cells (BMMC) (<i>n</i> = 12), and bone marrow-derived mononuclear cells (BMMC) combined with WJ (<i>n</i> = 15). Echocardiography assessed the left ventricular function and ejection fraction over four weeks. Histological and immunohistochemical analyses with anti-factor VIII evaluated angiogenesis and collagen types I and III. The results showed no statistically significant effect on ventricular remodeling 30 days post-acute myocardial infarction (AMI). Moreover, the infarct area was significantly smaller in the BMMC + WJ group compared to the control group, suggesting a potential benefit in reducing myocardial scarring. BMMC + WJ therapy demonstrated potential for functional improvement and infarct size reduction 30 days post-infarction. Further studies are needed to confirm its therapeutic benefits. |
| format | Article |
| id | doaj-art-85f7acf5d7ee40eb8796259733a3aacb |
| institution | Kabale University |
| issn | 2079-4983 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj-art-85f7acf5d7ee40eb8796259733a3aacb2025-08-20T03:47:57ZengMDPI AGJournal of Functional Biomaterials2079-49832025-05-0116517510.3390/jfb16050175Wharton’s Jelly Bioscaffolds Improve Cardiac Repair with Bone Marrow Mononuclear Stem Cells in RatsLuize Kremer Gamba0Laiza Kremer Gamba1Camila da Costa2Aline Luri Takejima3Rossana Baggio Simeoni4Isabella Cristina Mendes Rossa5Anna Clara Faidiga Silva6Julia Letícia de Bortolo7Marcos Antônio Denk8Seigo Nagashima9Carlos de Almeida Barbosa10Paulo Cesar Lock Silveira11Júlio César Francisco12Luiz César Guarita-Souza13Experimental Laboratory of Institute of Biological and Health Sciences, Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba 80215-901, PR, BrazilGraduate Program in Health Sciences, Centro Universitário para o Desenvolvimento do Alto Vale do Itajaí, Rio do Sul 89160-932, SC, BrazilLaboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, Universidade do Extremo Sul Catarinense, Criciúma 88806-000, SC, BrazilExperimental Laboratory of Institute of Biological and Health Sciences, Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba 80215-901, PR, BrazilExperimental Laboratory of Institute of Biological and Health Sciences, Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba 80215-901, PR, BrazilExperimental Laboratory of Institute of Biological and Health Sciences, Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba 80215-901, PR, BrazilExperimental Laboratory of Institute of Biological and Health Sciences, Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba 80215-901, PR, BrazilExperimental Laboratory of Institute of Biological and Health Sciences, Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba 80215-901, PR, BrazilExperimental Laboratory of Institute of Biological and Health Sciences, Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba 80215-901, PR, BrazilExperimental Laboratory of Institute of Biological and Health Sciences, Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba 80215-901, PR, BrazilGraduate Program in Pharmacy, Centro Universitário Curitiba—Unicuritiba, Curitiba 80220-181, PR, BrazilLaboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, Universidade do Extremo Sul Catarinense, Criciúma 88806-000, SC, BrazilExperimental Laboratory of Institute of Biological and Health Sciences, Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba 80215-901, PR, BrazilExperimental Laboratory of Institute of Biological and Health Sciences, Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba 80215-901, PR, BrazilThis study assessed the impact of implanting mononuclear stem cells and Wharton’s Jelly (WJ), either separately or together, on left ventricular dysfunction following myocardial infarction in Wistar rats. Functional and histopathological parameters were analyzed, and a rat model of left anterior descending coronary artery ligation was used. Treatments included an intramyocardial injection of 0.9% sodium chloride (control, <i>n</i> = 14), decellularized WJ (<i>n</i> = 12), bone marrow-derived mononuclear cells (BMMC) (<i>n</i> = 12), and bone marrow-derived mononuclear cells (BMMC) combined with WJ (<i>n</i> = 15). Echocardiography assessed the left ventricular function and ejection fraction over four weeks. Histological and immunohistochemical analyses with anti-factor VIII evaluated angiogenesis and collagen types I and III. The results showed no statistically significant effect on ventricular remodeling 30 days post-acute myocardial infarction (AMI). Moreover, the infarct area was significantly smaller in the BMMC + WJ group compared to the control group, suggesting a potential benefit in reducing myocardial scarring. BMMC + WJ therapy demonstrated potential for functional improvement and infarct size reduction 30 days post-infarction. Further studies are needed to confirm its therapeutic benefits.https://www.mdpi.com/2079-4983/16/5/175Wharton’s Jellybioscaffoldscardiac repairbone marrow mononuclear stem cellsmyocardial infarctiontissue engineering |
| spellingShingle | Luize Kremer Gamba Laiza Kremer Gamba Camila da Costa Aline Luri Takejima Rossana Baggio Simeoni Isabella Cristina Mendes Rossa Anna Clara Faidiga Silva Julia Letícia de Bortolo Marcos Antônio Denk Seigo Nagashima Carlos de Almeida Barbosa Paulo Cesar Lock Silveira Júlio César Francisco Luiz César Guarita-Souza Wharton’s Jelly Bioscaffolds Improve Cardiac Repair with Bone Marrow Mononuclear Stem Cells in Rats Journal of Functional Biomaterials Wharton’s Jelly bioscaffolds cardiac repair bone marrow mononuclear stem cells myocardial infarction tissue engineering |
| title | Wharton’s Jelly Bioscaffolds Improve Cardiac Repair with Bone Marrow Mononuclear Stem Cells in Rats |
| title_full | Wharton’s Jelly Bioscaffolds Improve Cardiac Repair with Bone Marrow Mononuclear Stem Cells in Rats |
| title_fullStr | Wharton’s Jelly Bioscaffolds Improve Cardiac Repair with Bone Marrow Mononuclear Stem Cells in Rats |
| title_full_unstemmed | Wharton’s Jelly Bioscaffolds Improve Cardiac Repair with Bone Marrow Mononuclear Stem Cells in Rats |
| title_short | Wharton’s Jelly Bioscaffolds Improve Cardiac Repair with Bone Marrow Mononuclear Stem Cells in Rats |
| title_sort | wharton s jelly bioscaffolds improve cardiac repair with bone marrow mononuclear stem cells in rats |
| topic | Wharton’s Jelly bioscaffolds cardiac repair bone marrow mononuclear stem cells myocardial infarction tissue engineering |
| url | https://www.mdpi.com/2079-4983/16/5/175 |
| work_keys_str_mv | AT luizekremergamba whartonsjellybioscaffoldsimprovecardiacrepairwithbonemarrowmononuclearstemcellsinrats AT laizakremergamba whartonsjellybioscaffoldsimprovecardiacrepairwithbonemarrowmononuclearstemcellsinrats AT camiladacosta whartonsjellybioscaffoldsimprovecardiacrepairwithbonemarrowmononuclearstemcellsinrats AT alineluritakejima whartonsjellybioscaffoldsimprovecardiacrepairwithbonemarrowmononuclearstemcellsinrats AT rossanabaggiosimeoni whartonsjellybioscaffoldsimprovecardiacrepairwithbonemarrowmononuclearstemcellsinrats AT isabellacristinamendesrossa whartonsjellybioscaffoldsimprovecardiacrepairwithbonemarrowmononuclearstemcellsinrats AT annaclarafaidigasilva whartonsjellybioscaffoldsimprovecardiacrepairwithbonemarrowmononuclearstemcellsinrats AT julialeticiadebortolo whartonsjellybioscaffoldsimprovecardiacrepairwithbonemarrowmononuclearstemcellsinrats AT marcosantoniodenk whartonsjellybioscaffoldsimprovecardiacrepairwithbonemarrowmononuclearstemcellsinrats AT seigonagashima whartonsjellybioscaffoldsimprovecardiacrepairwithbonemarrowmononuclearstemcellsinrats AT carlosdealmeidabarbosa whartonsjellybioscaffoldsimprovecardiacrepairwithbonemarrowmononuclearstemcellsinrats AT paulocesarlocksilveira whartonsjellybioscaffoldsimprovecardiacrepairwithbonemarrowmononuclearstemcellsinrats AT juliocesarfrancisco whartonsjellybioscaffoldsimprovecardiacrepairwithbonemarrowmononuclearstemcellsinrats AT luizcesarguaritasouza whartonsjellybioscaffoldsimprovecardiacrepairwithbonemarrowmononuclearstemcellsinrats |