Tirzepatide Versus Semaglutide on Weight Loss in Type 2 Diabetes Patients: A Systematic Review and Meta‐Analysis of Direct Comparative Studies
ABSTRACT Introduction Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) have emerged as an efficacious treatment for type 2 diabetes mellitus (T2DM) and have demonstrated substantial weight loss effects. This systematic review compares two prevalent GLP‐1RAs, tirzepatide and semaglutide, with the...
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| Format: | Article |
| Language: | English |
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Wiley
2025-05-01
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| Series: | Endocrinology, Diabetes & Metabolism |
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| Online Access: | https://doi.org/10.1002/edm2.70045 |
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| _version_ | 1850108489899180032 |
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| author | Jimmy Wen Burhaan Syed Denise Nadora Christiane How‐Volkman Ethan Bernstein Alina Truong Muzammil Akhtar Adam Razick Jose Puglisi Eldo Frezza |
| author_facet | Jimmy Wen Burhaan Syed Denise Nadora Christiane How‐Volkman Ethan Bernstein Alina Truong Muzammil Akhtar Adam Razick Jose Puglisi Eldo Frezza |
| author_sort | Jimmy Wen |
| collection | DOAJ |
| description | ABSTRACT Introduction Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) have emerged as an efficacious treatment for type 2 diabetes mellitus (T2DM) and have demonstrated substantial weight loss effects. This systematic review compares two prevalent GLP‐1RAs, tirzepatide and semaglutide, with their weight loss effects and rates of adverse events (AEs). Methods Following the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA), a systematic search was performed in PubMed, Embase and Cochrane Library for direct comparative studies between tirzepatide and semaglutide. A meta‐analysis was conducted via a random‐effects model to analyse the differences in weight loss outcomes between study cohorts. Results Four studies, with 28,827 patients (14,870 tirzepatide/13,928 semaglutide), mean age of 55.7 years (52.0 to 63.7) and mean follow‐up of 35.9 weeks (23.6 to 44.6), were included in this study. Mean weight change across four studies for tirzepatide and semaglutide was −11.4% (−15.3% to −8.27%) and −7.3% (−8.3% to −6.08%), respectively. The meta‐analysis supports these findings with a mean difference of −4.84 kg (95% CI: −6.21 to −3.47), favouring tirzepatide. The most common AEs were minor and moderate‐severity gastrointestinal (GI) AEs. Conclusion Current literature supports tirzepatide demonstrating a higher impact on weight loss than semaglutide, with both demonstrating high rates of minimal‐ to moderate‐severity AEs. Further research with comparative head‐to‐head trials will better elucidate these weight loss effects and safety profiles. |
| format | Article |
| id | doaj-art-85f515ca3f3f47b19634412a218824e0 |
| institution | OA Journals |
| issn | 2398-9238 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Endocrinology, Diabetes & Metabolism |
| spelling | doaj-art-85f515ca3f3f47b19634412a218824e02025-08-20T02:38:21ZengWileyEndocrinology, Diabetes & Metabolism2398-92382025-05-0183n/an/a10.1002/edm2.70045Tirzepatide Versus Semaglutide on Weight Loss in Type 2 Diabetes Patients: A Systematic Review and Meta‐Analysis of Direct Comparative StudiesJimmy Wen0Burhaan Syed1Denise Nadora2Christiane How‐Volkman3Ethan Bernstein4Alina Truong5Muzammil Akhtar6Adam Razick7Jose Puglisi8Eldo Frezza9California Northstate University College of Medicine Elk Grove California USACalifornia Northstate University College of Medicine Elk Grove California USACalifornia Northstate University College of Medicine Elk Grove California USACalifornia Northstate University College of Medicine Elk Grove California USACalifornia Northstate University College of Medicine Elk Grove California USACalifornia Northstate University College of Medicine Elk Grove California USACalifornia Northstate University College of Medicine Elk Grove California USAUniversity of California, Los Angeles Los Angeles California USACalifornia Northstate University College of Medicine Elk Grove California USACalifornia Northstate University College of Medicine Elk Grove California USAABSTRACT Introduction Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) have emerged as an efficacious treatment for type 2 diabetes mellitus (T2DM) and have demonstrated substantial weight loss effects. This systematic review compares two prevalent GLP‐1RAs, tirzepatide and semaglutide, with their weight loss effects and rates of adverse events (AEs). Methods Following the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA), a systematic search was performed in PubMed, Embase and Cochrane Library for direct comparative studies between tirzepatide and semaglutide. A meta‐analysis was conducted via a random‐effects model to analyse the differences in weight loss outcomes between study cohorts. Results Four studies, with 28,827 patients (14,870 tirzepatide/13,928 semaglutide), mean age of 55.7 years (52.0 to 63.7) and mean follow‐up of 35.9 weeks (23.6 to 44.6), were included in this study. Mean weight change across four studies for tirzepatide and semaglutide was −11.4% (−15.3% to −8.27%) and −7.3% (−8.3% to −6.08%), respectively. The meta‐analysis supports these findings with a mean difference of −4.84 kg (95% CI: −6.21 to −3.47), favouring tirzepatide. The most common AEs were minor and moderate‐severity gastrointestinal (GI) AEs. Conclusion Current literature supports tirzepatide demonstrating a higher impact on weight loss than semaglutide, with both demonstrating high rates of minimal‐ to moderate‐severity AEs. Further research with comparative head‐to‐head trials will better elucidate these weight loss effects and safety profiles.https://doi.org/10.1002/edm2.70045diabetesmeta‐analysissemaglutidetirzepatideweight loss |
| spellingShingle | Jimmy Wen Burhaan Syed Denise Nadora Christiane How‐Volkman Ethan Bernstein Alina Truong Muzammil Akhtar Adam Razick Jose Puglisi Eldo Frezza Tirzepatide Versus Semaglutide on Weight Loss in Type 2 Diabetes Patients: A Systematic Review and Meta‐Analysis of Direct Comparative Studies Endocrinology, Diabetes & Metabolism diabetes meta‐analysis semaglutide tirzepatide weight loss |
| title | Tirzepatide Versus Semaglutide on Weight Loss in Type 2 Diabetes Patients: A Systematic Review and Meta‐Analysis of Direct Comparative Studies |
| title_full | Tirzepatide Versus Semaglutide on Weight Loss in Type 2 Diabetes Patients: A Systematic Review and Meta‐Analysis of Direct Comparative Studies |
| title_fullStr | Tirzepatide Versus Semaglutide on Weight Loss in Type 2 Diabetes Patients: A Systematic Review and Meta‐Analysis of Direct Comparative Studies |
| title_full_unstemmed | Tirzepatide Versus Semaglutide on Weight Loss in Type 2 Diabetes Patients: A Systematic Review and Meta‐Analysis of Direct Comparative Studies |
| title_short | Tirzepatide Versus Semaglutide on Weight Loss in Type 2 Diabetes Patients: A Systematic Review and Meta‐Analysis of Direct Comparative Studies |
| title_sort | tirzepatide versus semaglutide on weight loss in type 2 diabetes patients a systematic review and meta analysis of direct comparative studies |
| topic | diabetes meta‐analysis semaglutide tirzepatide weight loss |
| url | https://doi.org/10.1002/edm2.70045 |
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