Betaleukin in therapy of chronic hepatitis C
The article presents the problems of modern antiviral therapy of chronic hepatitis C. The effectiveness of combined therapy with pegylated interferon and ribavirin in patients infected with 1st genotype is not more than 50%. Inclusion in the therapy HCV’s protease inhibitors (telaprevir and boceprev...
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| Format: | Article |
| Language: | Russian |
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Journal Infectology
2014-10-01
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| Series: | Журнал инфектологии |
| Subjects: | |
| Online Access: | https://journal.niidi.ru/jofin/article/view/336 |
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| _version_ | 1849687758246772736 |
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| author | E. S. Romanova N. I. Kuznetsov G. Yu. Startseva |
| author_facet | E. S. Romanova N. I. Kuznetsov G. Yu. Startseva |
| author_sort | E. S. Romanova |
| collection | DOAJ |
| description | The article presents the problems of modern antiviral therapy of chronic hepatitis C. The effectiveness of combined therapy with pegylated interferon and ribavirin in patients infected with 1st genotype is not more than 50%. Inclusion in the therapy HCV’s protease inhibitors (telaprevir and boceprevir) increases the sustainable virological response in patients with the 1st genotype, but this treatment is more expensive and accompanied by more serious complications. There is a large group of patients in Russia, who can’t have got such treatment because of its high cost. The results of clinical studies in application of betaleukin (recombinant IL-1β) in combined antiviral therapy of chronic hepatitis C also are analyzed. |
| format | Article |
| id | doaj-art-85f39705ef1849b79bc41c9915e78edf |
| institution | DOAJ |
| issn | 2072-6732 |
| language | Russian |
| publishDate | 2014-10-01 |
| publisher | Journal Infectology |
| record_format | Article |
| series | Журнал инфектологии |
| spelling | doaj-art-85f39705ef1849b79bc41c9915e78edf2025-08-20T03:22:15ZrusJournal InfectologyЖурнал инфектологии2072-67322014-10-0163273310.22625/2072-6732-2014-6-3-27-33350Betaleukin in therapy of chronic hepatitis CE. S. Romanova0N. I. Kuznetsov1G. Yu. Startseva2North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, RussiaNorth-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, RussiaNorth-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, RussiaThe article presents the problems of modern antiviral therapy of chronic hepatitis C. The effectiveness of combined therapy with pegylated interferon and ribavirin in patients infected with 1st genotype is not more than 50%. Inclusion in the therapy HCV’s protease inhibitors (telaprevir and boceprevir) increases the sustainable virological response in patients with the 1st genotype, but this treatment is more expensive and accompanied by more serious complications. There is a large group of patients in Russia, who can’t have got such treatment because of its high cost. The results of clinical studies in application of betaleukin (recombinant IL-1β) in combined antiviral therapy of chronic hepatitis C also are analyzed.https://journal.niidi.ru/jofin/article/view/336chronic hepatitis chepatitis c virusantiviral therapytelaprevirboceprevirbetaleukinrecombinant il-1β |
| spellingShingle | E. S. Romanova N. I. Kuznetsov G. Yu. Startseva Betaleukin in therapy of chronic hepatitis C Журнал инфектологии chronic hepatitis c hepatitis c virus antiviral therapy telaprevir boceprevir betaleukin recombinant il-1β |
| title | Betaleukin in therapy of chronic hepatitis C |
| title_full | Betaleukin in therapy of chronic hepatitis C |
| title_fullStr | Betaleukin in therapy of chronic hepatitis C |
| title_full_unstemmed | Betaleukin in therapy of chronic hepatitis C |
| title_short | Betaleukin in therapy of chronic hepatitis C |
| title_sort | betaleukin in therapy of chronic hepatitis c |
| topic | chronic hepatitis c hepatitis c virus antiviral therapy telaprevir boceprevir betaleukin recombinant il-1β |
| url | https://journal.niidi.ru/jofin/article/view/336 |
| work_keys_str_mv | AT esromanova betaleukinintherapyofchronichepatitisc AT nikuznetsov betaleukinintherapyofchronichepatitisc AT gyustartseva betaleukinintherapyofchronichepatitisc |