The association between systemic immune inflammation index and disease activity in patients with rheumatoid arthritis
Background. Novel blood-derived indices are a potential substitute for traditional inflammatory markers which have disputable correlations and clinical applications in different immunological diseases. Hereby, we aimed to reveal the association of neutrophil-to-lymphocyte ratio (NLR), platelet-to-ly...
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Amaltea Medical Publishing House
2024-06-01
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| Series: | Romanian Journal of Rheumatology |
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| Online Access: | https://rjr.com.ro/articles/2024.2/RJR_2024_2_Art-02.pdf |
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| author | Anahita Amirpour Rana Irilouzadian Hediyeh Baghsheikhi Maryam Armanfar Toktam Alirezaei |
| author_facet | Anahita Amirpour Rana Irilouzadian Hediyeh Baghsheikhi Maryam Armanfar Toktam Alirezaei |
| author_sort | Anahita Amirpour |
| collection | DOAJ |
| description | Background. Novel blood-derived indices are a potential substitute for traditional inflammatory markers which have disputable correlations and clinical applications in different immunological diseases. Hereby, we aimed to reveal the association of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immuneinflammation index (SII) with disease activity score (DAS28) and clinically active disease according to simple disease activity index (SDAI). Methods. We included 250 patients and they were grouped equally based on SDAI into two groups of patients in remission and with active disease. A blood sample was drawn from our patients to measure NLR, PLR, SII, rheumatoid factor, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP). Independent samples t-tests, chi-square, and Mann-Whitney U test were used accordingly. Logistic regression evaluated the factors that affect active RA. Results. PLR, DAS28, rheumatoid factor, quantitative and qualitative ESR and CRP had a significant difference between patients with active RA and in remission. SII had significant correlation with DAS28 but PLR and NLR were not correlated with DAS28. Also, PLR was the only index to be correlated with clinically active disease based on SDAI. The logistic regression showed that NLR, SII, ESR, and CRP were independent factors predicting active RA. Conclusion. We demonstrated that SII was significantly correlated with DAS28 and PLR was correlated with active RA. NLR, SII, CRP, and ESR were independent risk factors for RA flare-ups. |
| format | Article |
| id | doaj-art-85f30c1c3fbd4809b3dbbb17859d32e9 |
| institution | OA Journals |
| issn | 1843-0791 2069-6086 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Journal of Rheumatology |
| spelling | doaj-art-85f30c1c3fbd4809b3dbbb17859d32e92025-08-20T02:36:34ZengAmaltea Medical Publishing HouseRomanian Journal of Rheumatology1843-07912069-60862024-06-01332818610.37897/RJR.2024.2.2The association between systemic immune inflammation index and disease activity in patients with rheumatoid arthritisAnahita Amirpour0Rana Irilouzadian1https://orcid.org/0000-0001-8849-329XHediyeh Baghsheikhi2https://orcid.org/0000-0002-0984-6753Maryam Armanfar3Toktam Alirezaei4https://orcid.org/0000-0002-4473-7093Men’s Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranMen’s Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranMen’s Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranMen’s Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranMen’s Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranBackground. Novel blood-derived indices are a potential substitute for traditional inflammatory markers which have disputable correlations and clinical applications in different immunological diseases. Hereby, we aimed to reveal the association of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immuneinflammation index (SII) with disease activity score (DAS28) and clinically active disease according to simple disease activity index (SDAI). Methods. We included 250 patients and they were grouped equally based on SDAI into two groups of patients in remission and with active disease. A blood sample was drawn from our patients to measure NLR, PLR, SII, rheumatoid factor, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP). Independent samples t-tests, chi-square, and Mann-Whitney U test were used accordingly. Logistic regression evaluated the factors that affect active RA. Results. PLR, DAS28, rheumatoid factor, quantitative and qualitative ESR and CRP had a significant difference between patients with active RA and in remission. SII had significant correlation with DAS28 but PLR and NLR were not correlated with DAS28. Also, PLR was the only index to be correlated with clinically active disease based on SDAI. The logistic regression showed that NLR, SII, ESR, and CRP were independent factors predicting active RA. Conclusion. We demonstrated that SII was significantly correlated with DAS28 and PLR was correlated with active RA. NLR, SII, CRP, and ESR were independent risk factors for RA flare-ups.https://rjr.com.ro/articles/2024.2/RJR_2024_2_Art-02.pdfneutrophil-to-lymphocyte ratioplatelet-to-lymphocyte ratiosystemic immune-inflammation indexrheumatoid arthritisdisease activity scoredas28 |
| spellingShingle | Anahita Amirpour Rana Irilouzadian Hediyeh Baghsheikhi Maryam Armanfar Toktam Alirezaei The association between systemic immune inflammation index and disease activity in patients with rheumatoid arthritis Romanian Journal of Rheumatology neutrophil-to-lymphocyte ratio platelet-to-lymphocyte ratio systemic immune-inflammation index rheumatoid arthritis disease activity score das28 |
| title | The association between systemic immune inflammation index and disease activity in patients with rheumatoid arthritis |
| title_full | The association between systemic immune inflammation index and disease activity in patients with rheumatoid arthritis |
| title_fullStr | The association between systemic immune inflammation index and disease activity in patients with rheumatoid arthritis |
| title_full_unstemmed | The association between systemic immune inflammation index and disease activity in patients with rheumatoid arthritis |
| title_short | The association between systemic immune inflammation index and disease activity in patients with rheumatoid arthritis |
| title_sort | association between systemic immune inflammation index and disease activity in patients with rheumatoid arthritis |
| topic | neutrophil-to-lymphocyte ratio platelet-to-lymphocyte ratio systemic immune-inflammation index rheumatoid arthritis disease activity score das28 |
| url | https://rjr.com.ro/articles/2024.2/RJR_2024_2_Art-02.pdf |
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