Improving Cell Engraftment in Cardiac Stem Cell Therapy
Myocardial infarction (MI) affects millions of people worldwide. MI causes massive cardiac cell death and heart function decrease. However, heart tissue cannot effectively regenerate by itself. While stem cell therapy has been considered an effective approach for regeneration, the efficacy of cardia...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/7168797 |
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| _version_ | 1849401241907494912 |
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| author | Xiaofei Li Kenichi Tamama Xiaoyun Xie Jianjun Guan |
| author_facet | Xiaofei Li Kenichi Tamama Xiaoyun Xie Jianjun Guan |
| author_sort | Xiaofei Li |
| collection | DOAJ |
| description | Myocardial infarction (MI) affects millions of people worldwide. MI causes massive cardiac cell death and heart function decrease. However, heart tissue cannot effectively regenerate by itself. While stem cell therapy has been considered an effective approach for regeneration, the efficacy of cardiac stem cell therapy remains low due to inferior cell engraftment in the infarcted region. This is mainly a result of low cell retention in the tissue and poor cell survival under ischemic, immune rejection and inflammatory conditions. Various approaches have been explored to improve cell engraftment: increase of cell retention using biomaterials as cell carriers; augmentation of cell survival under ischemic conditions by preconditioning cells, genetic modification of cells, and controlled release of growth factors and oxygen; and enhancement of cell survival by protecting cells from excessive inflammation and immune surveillance. In this paper, we review current progress, advantages, disadvantages, and potential solutions of these approaches. |
| format | Article |
| id | doaj-art-85f00a8fae484248891bc2cfc0296b0f |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-85f00a8fae484248891bc2cfc0296b0f2025-08-20T03:37:49ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/71687977168797Improving Cell Engraftment in Cardiac Stem Cell TherapyXiaofei Li0Kenichi Tamama1Xiaoyun Xie2Jianjun Guan3Department of Materials Science and Engineering, The Ohio State University, 2041 College Road, Columbus, OH 43210, USADepartment of Pathology, University of Pittsburgh School of Medicine, 3550 Terrace Street, Pittsburgh, PA 15261, USADepartment of Gerontology, Tongji Hospital, Tongji University, Shanghai 200065, ChinaDepartment of Materials Science and Engineering, The Ohio State University, 2041 College Road, Columbus, OH 43210, USAMyocardial infarction (MI) affects millions of people worldwide. MI causes massive cardiac cell death and heart function decrease. However, heart tissue cannot effectively regenerate by itself. While stem cell therapy has been considered an effective approach for regeneration, the efficacy of cardiac stem cell therapy remains low due to inferior cell engraftment in the infarcted region. This is mainly a result of low cell retention in the tissue and poor cell survival under ischemic, immune rejection and inflammatory conditions. Various approaches have been explored to improve cell engraftment: increase of cell retention using biomaterials as cell carriers; augmentation of cell survival under ischemic conditions by preconditioning cells, genetic modification of cells, and controlled release of growth factors and oxygen; and enhancement of cell survival by protecting cells from excessive inflammation and immune surveillance. In this paper, we review current progress, advantages, disadvantages, and potential solutions of these approaches.http://dx.doi.org/10.1155/2016/7168797 |
| spellingShingle | Xiaofei Li Kenichi Tamama Xiaoyun Xie Jianjun Guan Improving Cell Engraftment in Cardiac Stem Cell Therapy Stem Cells International |
| title | Improving Cell Engraftment in Cardiac Stem Cell Therapy |
| title_full | Improving Cell Engraftment in Cardiac Stem Cell Therapy |
| title_fullStr | Improving Cell Engraftment in Cardiac Stem Cell Therapy |
| title_full_unstemmed | Improving Cell Engraftment in Cardiac Stem Cell Therapy |
| title_short | Improving Cell Engraftment in Cardiac Stem Cell Therapy |
| title_sort | improving cell engraftment in cardiac stem cell therapy |
| url | http://dx.doi.org/10.1155/2016/7168797 |
| work_keys_str_mv | AT xiaofeili improvingcellengraftmentincardiacstemcelltherapy AT kenichitamama improvingcellengraftmentincardiacstemcelltherapy AT xiaoyunxie improvingcellengraftmentincardiacstemcelltherapy AT jianjunguan improvingcellengraftmentincardiacstemcelltherapy |