Perspectives on NcRNAs in HBV/cccDNA-driven HCC progression

Perspectives on NcRNAs in HBV/cccDNA-driven HCC progression

Abstract Hepatitis B virus (HBV) integration, the HBx protein (and its mutants), and covalently closed circular DNA (cccDNA) are critical for HBV replication, packaging, and transmission to new host cells. Although nucleos(t)ide analogs (NAs) are a class of antiviral drugs that effectively suppress...

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Bibliographic Details
Main Authors: Yang-Hsiang Lin, Ming-Wei Lai, Chau-Ting Yeh, Wey-Ran Lin
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Cancer Cell International
Subjects:
HBV
HBx
CccDNA
Nucleos(t)ide analogue
HCC
NcRNAs
Online Access:https://doi.org/10.1186/s12935-025-03849-0
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