Lenalidomide and Dexamethasone for a Patient of POEMS Syndrome Presenting with Massive Ascites
POEMS syndrome is a multisystem disorder characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes. POEMS syndrome is a rare cause of refractory ascites. We report the case of a patient with POEMS syndrome presenting with massive ascites who was treated w...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2014/818946 |
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| author | Shuji Ueda Sayoko Yonemoto Kazumasa Oka Naohiko Fujii Keiichi Nakata Hitomi Matsunaga Seiko Kataoka Yuki Iwama Hiroyuki Narahara Yuichi Yasunaga Yoshiaki Inui Sumio Kawata |
| author_facet | Shuji Ueda Sayoko Yonemoto Kazumasa Oka Naohiko Fujii Keiichi Nakata Hitomi Matsunaga Seiko Kataoka Yuki Iwama Hiroyuki Narahara Yuichi Yasunaga Yoshiaki Inui Sumio Kawata |
| author_sort | Shuji Ueda |
| collection | DOAJ |
| description | POEMS syndrome is a multisystem disorder characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes. POEMS syndrome is a rare cause of refractory ascites. We report the case of a patient with POEMS syndrome presenting with massive ascites who was treated with very-low-dose lenalidomide and dexamethasone. A 57-year-old Japanese man was admitted to our hospital with pleural effusion, massive ascites, and leg edema. The diagnosis of POEMS syndrome was made based on the combination of the following findings: peripheral neuropathy, organomegaly, endocrinopathy, serum monoclonal protein elevation, skin changes, plasma VEGF elevation, and evidence of extravascular volume overload. Renal dysfunction induced by biopsy-proven renal involvement of POEMS syndrome was observed. Massive ascites of the patient dramatically diminished with long-time treatment of very-low-dose lenalidomide and dexamethasone. Lenalidomide seems to be a very promising therapy for POEMS syndrome presenting with extravascular volume overload such as edema, pleural effusion, and ascites. Very-low-dose lenalidomide might be effective especially for the patients with POEMS-related nephropathy. |
| format | Article |
| id | doaj-art-85ddf6ffc4b24572a46a738e3458a3a2 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-85ddf6ffc4b24572a46a738e3458a3a22025-02-03T06:07:09ZengWileyCase Reports in Hematology2090-65602090-65792014-01-01201410.1155/2014/818946818946Lenalidomide and Dexamethasone for a Patient of POEMS Syndrome Presenting with Massive AscitesShuji Ueda0Sayoko Yonemoto1Kazumasa Oka2Naohiko Fujii3Keiichi Nakata4Hitomi Matsunaga5Seiko Kataoka6Yuki Iwama7Hiroyuki Narahara8Yuichi Yasunaga9Yoshiaki Inui10Sumio Kawata11Department of Internal Medicine, Hyogo Prefectural Nishinomiya Hospital, 13-9 Rokutanji-cho, Nishinomiya, Hyogo 662-0918, JapanDepartment of Internal Medicine, Hyogo Prefectural Nishinomiya Hospital, 13-9 Rokutanji-cho, Nishinomiya, Hyogo 662-0918, JapanDepartment of Pathology, Hyogo Prefectural Nishinomiya Hospital, 13-9 Rokutanji-cho, Nishinomiya, Hyogo 662-0918, JapanDepartment of Internal Medicine, Hyogo Prefectural Nishinomiya Hospital, 13-9 Rokutanji-cho, Nishinomiya, Hyogo 662-0918, JapanDepartment of Internal Medicine, Hyogo Prefectural Nishinomiya Hospital, 13-9 Rokutanji-cho, Nishinomiya, Hyogo 662-0918, JapanDepartment of Internal Medicine, Hyogo Prefectural Nishinomiya Hospital, 13-9 Rokutanji-cho, Nishinomiya, Hyogo 662-0918, JapanDepartment of Internal Medicine, Hyogo Prefectural Nishinomiya Hospital, 13-9 Rokutanji-cho, Nishinomiya, Hyogo 662-0918, JapanDepartment of Radiology, Hyogo Prefectural Nishinomiya Hospital, 13-9 Rokutanji-cho, Nishinomiya, Hyogo 662-0918, JapanDepartment of Internal Medicine, Hyogo Prefectural Nishinomiya Hospital, 13-9 Rokutanji-cho, Nishinomiya, Hyogo 662-0918, JapanDepartment of Internal Medicine, Hyogo Prefectural Nishinomiya Hospital, 13-9 Rokutanji-cho, Nishinomiya, Hyogo 662-0918, JapanDepartment of Internal Medicine, Hyogo Prefectural Nishinomiya Hospital, 13-9 Rokutanji-cho, Nishinomiya, Hyogo 662-0918, JapanDepartment of Internal Medicine, Hyogo Prefectural Nishinomiya Hospital, 13-9 Rokutanji-cho, Nishinomiya, Hyogo 662-0918, JapanPOEMS syndrome is a multisystem disorder characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes. POEMS syndrome is a rare cause of refractory ascites. We report the case of a patient with POEMS syndrome presenting with massive ascites who was treated with very-low-dose lenalidomide and dexamethasone. A 57-year-old Japanese man was admitted to our hospital with pleural effusion, massive ascites, and leg edema. The diagnosis of POEMS syndrome was made based on the combination of the following findings: peripheral neuropathy, organomegaly, endocrinopathy, serum monoclonal protein elevation, skin changes, plasma VEGF elevation, and evidence of extravascular volume overload. Renal dysfunction induced by biopsy-proven renal involvement of POEMS syndrome was observed. Massive ascites of the patient dramatically diminished with long-time treatment of very-low-dose lenalidomide and dexamethasone. Lenalidomide seems to be a very promising therapy for POEMS syndrome presenting with extravascular volume overload such as edema, pleural effusion, and ascites. Very-low-dose lenalidomide might be effective especially for the patients with POEMS-related nephropathy.http://dx.doi.org/10.1155/2014/818946 |
| spellingShingle | Shuji Ueda Sayoko Yonemoto Kazumasa Oka Naohiko Fujii Keiichi Nakata Hitomi Matsunaga Seiko Kataoka Yuki Iwama Hiroyuki Narahara Yuichi Yasunaga Yoshiaki Inui Sumio Kawata Lenalidomide and Dexamethasone for a Patient of POEMS Syndrome Presenting with Massive Ascites Case Reports in Hematology |
| title | Lenalidomide and Dexamethasone for a Patient of POEMS Syndrome Presenting with Massive Ascites |
| title_full | Lenalidomide and Dexamethasone for a Patient of POEMS Syndrome Presenting with Massive Ascites |
| title_fullStr | Lenalidomide and Dexamethasone for a Patient of POEMS Syndrome Presenting with Massive Ascites |
| title_full_unstemmed | Lenalidomide and Dexamethasone for a Patient of POEMS Syndrome Presenting with Massive Ascites |
| title_short | Lenalidomide and Dexamethasone for a Patient of POEMS Syndrome Presenting with Massive Ascites |
| title_sort | lenalidomide and dexamethasone for a patient of poems syndrome presenting with massive ascites |
| url | http://dx.doi.org/10.1155/2014/818946 |
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