The association between thyroid function and insulin resistance as measured by the metabolic score for insulin resistance (METS-IR): insights from NHANES 2007–2012
Abstract Background Altered thyroid function has been linked to insulin resistance (IR), but its relationship with the Metabolic Score for Insulin Resistance (METS-IR), a novel non-insulin-based index of IR, remains unclear. This study aimed to investigate the association between thyroid function st...
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2024-12-01
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| Series: | BMC Endocrine Disorders |
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| Online Access: | https://doi.org/10.1186/s12902-024-01779-y |
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| author | Farima Safari Ali Nabavizadeh Hossein Molavi Vardanjani |
| author_facet | Farima Safari Ali Nabavizadeh Hossein Molavi Vardanjani |
| author_sort | Farima Safari |
| collection | DOAJ |
| description | Abstract Background Altered thyroid function has been linked to insulin resistance (IR), but its relationship with the Metabolic Score for Insulin Resistance (METS-IR), a novel non-insulin-based index of IR, remains unclear. This study aimed to investigate the association between thyroid function status and METS-IR in a U.S. population. Methods This cross-sectional study utilized data from 6,507 adults (aged ≥ 20 years) participating in the National Health and Nutrition Examination Survey from 2007 to 2012. Thyroid function status was categorized into five groups based on thyroid-stimulating hormone and free thyroxine levels. METS-IR was calculated from measures of fasting glucose, triglycerides, high-density lipoprotein cholesterol (HDL-C), and body mass index (BMI). Multivariate regression analyzed the relationship between thyroid status and METS-IR after adjusting for potential confounders. Results Higher thyroid-stimulating hormone levels were positively associated with METS-IR (β = 0.003, 95% CI 0.001–0.004, p = 0.021). Subclinical hypothyroidism in males and subclinical hyperthyroidism in females showed significant correlations with higher METS-IR. Thyroid peroxidase antibodies (TPO Ab) positivity strengthened the association between overt hypothyroidism and METS-IR. Conclusions This study demonstrates significant associations between thyroid function status, particularly subclinical thyroid dysfunction, and insulin resistance as measured by METS-IR in a U.S. population. Thyroid status may serve as an early marker of insulin resistance risk. |
| format | Article |
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| institution | OA Journals |
| issn | 1472-6823 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
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| series | BMC Endocrine Disorders |
| spelling | doaj-art-85dc1d35fd984594b751e4da214d90d92025-08-20T02:31:38ZengBMCBMC Endocrine Disorders1472-68232024-12-0124111210.1186/s12902-024-01779-yThe association between thyroid function and insulin resistance as measured by the metabolic score for insulin resistance (METS-IR): insights from NHANES 2007–2012Farima Safari0Ali Nabavizadeh1Hossein Molavi Vardanjani2Student Research Committee, School of Medicine, Shiraz University of Medical SciencesStudent Research Committee, School of Medicine, Shiraz University of Medical SciencesHealth Policy Research Center, Institute of Health, Shiraz University of Medical SciencesAbstract Background Altered thyroid function has been linked to insulin resistance (IR), but its relationship with the Metabolic Score for Insulin Resistance (METS-IR), a novel non-insulin-based index of IR, remains unclear. This study aimed to investigate the association between thyroid function status and METS-IR in a U.S. population. Methods This cross-sectional study utilized data from 6,507 adults (aged ≥ 20 years) participating in the National Health and Nutrition Examination Survey from 2007 to 2012. Thyroid function status was categorized into five groups based on thyroid-stimulating hormone and free thyroxine levels. METS-IR was calculated from measures of fasting glucose, triglycerides, high-density lipoprotein cholesterol (HDL-C), and body mass index (BMI). Multivariate regression analyzed the relationship between thyroid status and METS-IR after adjusting for potential confounders. Results Higher thyroid-stimulating hormone levels were positively associated with METS-IR (β = 0.003, 95% CI 0.001–0.004, p = 0.021). Subclinical hypothyroidism in males and subclinical hyperthyroidism in females showed significant correlations with higher METS-IR. Thyroid peroxidase antibodies (TPO Ab) positivity strengthened the association between overt hypothyroidism and METS-IR. Conclusions This study demonstrates significant associations between thyroid function status, particularly subclinical thyroid dysfunction, and insulin resistance as measured by METS-IR in a U.S. population. Thyroid status may serve as an early marker of insulin resistance risk.https://doi.org/10.1186/s12902-024-01779-yThyroid functionInsulin resistanceMETS-IR |
| spellingShingle | Farima Safari Ali Nabavizadeh Hossein Molavi Vardanjani The association between thyroid function and insulin resistance as measured by the metabolic score for insulin resistance (METS-IR): insights from NHANES 2007–2012 BMC Endocrine Disorders Thyroid function Insulin resistance METS-IR |
| title | The association between thyroid function and insulin resistance as measured by the metabolic score for insulin resistance (METS-IR): insights from NHANES 2007–2012 |
| title_full | The association between thyroid function and insulin resistance as measured by the metabolic score for insulin resistance (METS-IR): insights from NHANES 2007–2012 |
| title_fullStr | The association between thyroid function and insulin resistance as measured by the metabolic score for insulin resistance (METS-IR): insights from NHANES 2007–2012 |
| title_full_unstemmed | The association between thyroid function and insulin resistance as measured by the metabolic score for insulin resistance (METS-IR): insights from NHANES 2007–2012 |
| title_short | The association between thyroid function and insulin resistance as measured by the metabolic score for insulin resistance (METS-IR): insights from NHANES 2007–2012 |
| title_sort | association between thyroid function and insulin resistance as measured by the metabolic score for insulin resistance mets ir insights from nhanes 2007 2012 |
| topic | Thyroid function Insulin resistance METS-IR |
| url | https://doi.org/10.1186/s12902-024-01779-y |
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