Evaluating the Impact of Eosinophil Count on the Long-term Clinical Outcomes of Patients With an Acute ST-segment Elevation Myocardial Infarction Who Require Emergency Percutaneous Coronary Intervention: Results of a Multicenter Cohort Study
Abstract. Objective:. Eosinophils (EOS) are inflammatory innate immune cells that play an important role in arterial thrombogenesis. There is a paucity of data on whether EOS levels have an impact on long-term outcomes following ST-segment elevation myocardial infarction (STEMI). This study aimed t...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Health/LWW
2024-12-01
|
| Series: | Cardiology Discovery |
| Online Access: | http://journals.lww.com/10.1097/CD9.0000000000000140 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850213872524328960 |
|---|---|
| author | Lei Guo Hao Liu Zhichao Dong Xuchen Zhou Hao Zhu Xia Gu Bo Zhang Hanjia Gao Xiaoxia Fu |
| author_facet | Lei Guo Hao Liu Zhichao Dong Xuchen Zhou Hao Zhu Xia Gu Bo Zhang Hanjia Gao Xiaoxia Fu |
| author_sort | Lei Guo |
| collection | DOAJ |
| description | Abstract.
Objective:. Eosinophils (EOS) are inflammatory innate immune cells that play an important role in arterial thrombogenesis. There is a paucity of data on whether EOS levels have an impact on long-term outcomes following ST-segment elevation myocardial infarction (STEMI). This study aimed to investigate the impact of EOS count on the clinical outcomes of STEMI patients who underwent emergency percutaneous coronary intervention (PCI).
Methods:. This is a retrospective multicenter cohort study. A total of 754 patients with STEMI who required emergency PCI at 5 centers were screened between October 2015 and November 2016. Patients were divided into 2 groups based on EOS count: EOS count <0.02 × 109/L group (n = 264) and EOS count ≥0.02 × 109/L group (n = 490). Baseline demographic characteristics, clinical information, and medical test data were collected at study entry. The primary endpoint was all-cause death. The secondary endpoint was a major adverse cardiac event. Multivariablete Cox regression analysis was performed to identify the independent predictors of all-cause death, with a follow-up period of 5 years.
Results:. The incidence of all-cause death (14.8% vs. 7.6%, P = 0.002) and major adverse cardiac event (20.1% vs. 13.1%, P = 0.011) were significantly higher in EOS count <0.02 × 109/L group compared with ≥0.02 × 109/L group. Multivariablete Cox regression analysis showed that an EOS count <0.02 × 109/L, age ≥65 years, previous heart failure, previous stroke, and left ventricular ejection fraction ≤ 40% were independent predictors of all-cause death in patients with STEMI who underwent an emergency PCI.
Conclusions:. Low EOS counts were associated with all-cause mortality in STEMI patients who underwent emergency PCI. |
| format | Article |
| id | doaj-art-85d950778be54552a769ee8c685d37e1 |
| institution | OA Journals |
| issn | 2096-952X 2693-8499 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Health/LWW |
| record_format | Article |
| series | Cardiology Discovery |
| spelling | doaj-art-85d950778be54552a769ee8c685d37e12025-08-20T02:09:02ZengWolters Kluwer Health/LWWCardiology Discovery2096-952X2693-84992024-12-014427427910.1097/CD9.0000000000000140202412000-00003Evaluating the Impact of Eosinophil Count on the Long-term Clinical Outcomes of Patients With an Acute ST-segment Elevation Myocardial Infarction Who Require Emergency Percutaneous Coronary Intervention: Results of a Multicenter Cohort StudyLei Guo0Hao Liu1Zhichao Dong2Xuchen Zhou3Hao Zhu4Xia Gu5Bo Zhang6Hanjia GaoXiaoxia Fu1 Department of Cardiology, the First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, China1 Department of Cardiology, the First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, China1 Department of Cardiology, the First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, China1 Department of Cardiology, the First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, China1 Department of Cardiology, the First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, China2 Department of Cardiology, the Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, China1 Department of Cardiology, the First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, ChinaAbstract. Objective:. Eosinophils (EOS) are inflammatory innate immune cells that play an important role in arterial thrombogenesis. There is a paucity of data on whether EOS levels have an impact on long-term outcomes following ST-segment elevation myocardial infarction (STEMI). This study aimed to investigate the impact of EOS count on the clinical outcomes of STEMI patients who underwent emergency percutaneous coronary intervention (PCI). Methods:. This is a retrospective multicenter cohort study. A total of 754 patients with STEMI who required emergency PCI at 5 centers were screened between October 2015 and November 2016. Patients were divided into 2 groups based on EOS count: EOS count <0.02 × 109/L group (n = 264) and EOS count ≥0.02 × 109/L group (n = 490). Baseline demographic characteristics, clinical information, and medical test data were collected at study entry. The primary endpoint was all-cause death. The secondary endpoint was a major adverse cardiac event. Multivariablete Cox regression analysis was performed to identify the independent predictors of all-cause death, with a follow-up period of 5 years. Results:. The incidence of all-cause death (14.8% vs. 7.6%, P = 0.002) and major adverse cardiac event (20.1% vs. 13.1%, P = 0.011) were significantly higher in EOS count <0.02 × 109/L group compared with ≥0.02 × 109/L group. Multivariablete Cox regression analysis showed that an EOS count <0.02 × 109/L, age ≥65 years, previous heart failure, previous stroke, and left ventricular ejection fraction ≤ 40% were independent predictors of all-cause death in patients with STEMI who underwent an emergency PCI. Conclusions:. Low EOS counts were associated with all-cause mortality in STEMI patients who underwent emergency PCI.http://journals.lww.com/10.1097/CD9.0000000000000140 |
| spellingShingle | Lei Guo Hao Liu Zhichao Dong Xuchen Zhou Hao Zhu Xia Gu Bo Zhang Hanjia Gao Xiaoxia Fu Evaluating the Impact of Eosinophil Count on the Long-term Clinical Outcomes of Patients With an Acute ST-segment Elevation Myocardial Infarction Who Require Emergency Percutaneous Coronary Intervention: Results of a Multicenter Cohort Study Cardiology Discovery |
| title | Evaluating the Impact of Eosinophil Count on the Long-term Clinical Outcomes of Patients With an Acute ST-segment Elevation Myocardial Infarction Who Require Emergency Percutaneous Coronary Intervention: Results of a Multicenter Cohort Study |
| title_full | Evaluating the Impact of Eosinophil Count on the Long-term Clinical Outcomes of Patients With an Acute ST-segment Elevation Myocardial Infarction Who Require Emergency Percutaneous Coronary Intervention: Results of a Multicenter Cohort Study |
| title_fullStr | Evaluating the Impact of Eosinophil Count on the Long-term Clinical Outcomes of Patients With an Acute ST-segment Elevation Myocardial Infarction Who Require Emergency Percutaneous Coronary Intervention: Results of a Multicenter Cohort Study |
| title_full_unstemmed | Evaluating the Impact of Eosinophil Count on the Long-term Clinical Outcomes of Patients With an Acute ST-segment Elevation Myocardial Infarction Who Require Emergency Percutaneous Coronary Intervention: Results of a Multicenter Cohort Study |
| title_short | Evaluating the Impact of Eosinophil Count on the Long-term Clinical Outcomes of Patients With an Acute ST-segment Elevation Myocardial Infarction Who Require Emergency Percutaneous Coronary Intervention: Results of a Multicenter Cohort Study |
| title_sort | evaluating the impact of eosinophil count on the long term clinical outcomes of patients with an acute st segment elevation myocardial infarction who require emergency percutaneous coronary intervention results of a multicenter cohort study |
| url | http://journals.lww.com/10.1097/CD9.0000000000000140 |
| work_keys_str_mv | AT leiguo evaluatingtheimpactofeosinophilcountonthelongtermclinicaloutcomesofpatientswithanacutestsegmentelevationmyocardialinfarctionwhorequireemergencypercutaneouscoronaryinterventionresultsofamulticentercohortstudy AT haoliu evaluatingtheimpactofeosinophilcountonthelongtermclinicaloutcomesofpatientswithanacutestsegmentelevationmyocardialinfarctionwhorequireemergencypercutaneouscoronaryinterventionresultsofamulticentercohortstudy AT zhichaodong evaluatingtheimpactofeosinophilcountonthelongtermclinicaloutcomesofpatientswithanacutestsegmentelevationmyocardialinfarctionwhorequireemergencypercutaneouscoronaryinterventionresultsofamulticentercohortstudy AT xuchenzhou evaluatingtheimpactofeosinophilcountonthelongtermclinicaloutcomesofpatientswithanacutestsegmentelevationmyocardialinfarctionwhorequireemergencypercutaneouscoronaryinterventionresultsofamulticentercohortstudy AT haozhu evaluatingtheimpactofeosinophilcountonthelongtermclinicaloutcomesofpatientswithanacutestsegmentelevationmyocardialinfarctionwhorequireemergencypercutaneouscoronaryinterventionresultsofamulticentercohortstudy AT xiagu evaluatingtheimpactofeosinophilcountonthelongtermclinicaloutcomesofpatientswithanacutestsegmentelevationmyocardialinfarctionwhorequireemergencypercutaneouscoronaryinterventionresultsofamulticentercohortstudy AT bozhang evaluatingtheimpactofeosinophilcountonthelongtermclinicaloutcomesofpatientswithanacutestsegmentelevationmyocardialinfarctionwhorequireemergencypercutaneouscoronaryinterventionresultsofamulticentercohortstudy AT hanjiagao evaluatingtheimpactofeosinophilcountonthelongtermclinicaloutcomesofpatientswithanacutestsegmentelevationmyocardialinfarctionwhorequireemergencypercutaneouscoronaryinterventionresultsofamulticentercohortstudy AT xiaoxiafu evaluatingtheimpactofeosinophilcountonthelongtermclinicaloutcomesofpatientswithanacutestsegmentelevationmyocardialinfarctionwhorequireemergencypercutaneouscoronaryinterventionresultsofamulticentercohortstudy |