Molecular basis for new approaches to therapy of osteoarthritis (part I)
Osteoarthritis (OA) is the most common disease of the elderly, which is accompanied by pain and damages all tissues of the joint. OA is associated with progressive loss of articular cartilage, sclerotic changes in the subchondral bone and the formation of osteophytes. Cartilage destruction is caused...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
IMA-PRESS LLC
2021-08-01
|
| Series: | Современная ревматология |
| Subjects: | |
| Online Access: | https://mrj.ima-press.net/mrj/article/view/1165 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849691622974947328 |
|---|---|
| author | E. V. Chetina G. A. Markova A. M. Lila |
| author_facet | E. V. Chetina G. A. Markova A. M. Lila |
| author_sort | E. V. Chetina |
| collection | DOAJ |
| description | Osteoarthritis (OA) is the most common disease of the elderly, which is accompanied by pain and damages all tissues of the joint. OA is associated with progressive loss of articular cartilage, sclerotic changes in the subchondral bone and the formation of osteophytes. Cartilage destruction is caused by resorption of the extracellular matrix, which consists mainly of type II collagen and aggrecan proteoglycan. Excessive cleavage of type II collagen in OA is associated with increased synthesis and activity of metalloproteinases and the expression of pro-inflammatory cytokines of interleukin 1β and tumor necrosis factor α. Currently, OA therapy is symptomatic, often ineffective, and in some cases is accompanied by adverse side effects. Therefore, the search for new therapeutic approaches to the treatment of the disease, using modern technological capabilities and knowledge of the metabolic disorders that cause the disease. The review presents new promising methods in the treatment of OA using stem cells and subcellular structures, based on modern knowledge of molecular and cellular mechanisms that are disrupted during development and disease progression. |
| format | Article |
| id | doaj-art-85cacb19bac14127a34c215ec7a75813 |
| institution | DOAJ |
| issn | 1996-7012 2310-158X |
| language | Russian |
| publishDate | 2021-08-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Современная ревматология |
| spelling | doaj-art-85cacb19bac14127a34c215ec7a758132025-08-20T03:20:59ZrusIMA-PRESS LLCСовременная ревматология1996-70122310-158X2021-08-0115471210.14412/1996-7012-2021-4-7-122375Molecular basis for new approaches to therapy of osteoarthritis (part I)E. V. Chetina0G. A. Markova1A. M. Lila2V.A. Nasonova Research Institute of RheumatologyV.A. Nasonova Research Institute of RheumatologyV.A. Nasonova Research Institute of Rheumatology; Russian Medical Academy of Continuing Professional EducationOsteoarthritis (OA) is the most common disease of the elderly, which is accompanied by pain and damages all tissues of the joint. OA is associated with progressive loss of articular cartilage, sclerotic changes in the subchondral bone and the formation of osteophytes. Cartilage destruction is caused by resorption of the extracellular matrix, which consists mainly of type II collagen and aggrecan proteoglycan. Excessive cleavage of type II collagen in OA is associated with increased synthesis and activity of metalloproteinases and the expression of pro-inflammatory cytokines of interleukin 1β and tumor necrosis factor α. Currently, OA therapy is symptomatic, often ineffective, and in some cases is accompanied by adverse side effects. Therefore, the search for new therapeutic approaches to the treatment of the disease, using modern technological capabilities and knowledge of the metabolic disorders that cause the disease. The review presents new promising methods in the treatment of OA using stem cells and subcellular structures, based on modern knowledge of molecular and cellular mechanisms that are disrupted during development and disease progression.https://mrj.ima-press.net/mrj/article/view/1165osteoarthritistherapymolecular mechanismsstem cellsmimetics |
| spellingShingle | E. V. Chetina G. A. Markova A. M. Lila Molecular basis for new approaches to therapy of osteoarthritis (part I) Современная ревматология osteoarthritis therapy molecular mechanisms stem cells mimetics |
| title | Molecular basis for new approaches to therapy of osteoarthritis (part I) |
| title_full | Molecular basis for new approaches to therapy of osteoarthritis (part I) |
| title_fullStr | Molecular basis for new approaches to therapy of osteoarthritis (part I) |
| title_full_unstemmed | Molecular basis for new approaches to therapy of osteoarthritis (part I) |
| title_short | Molecular basis for new approaches to therapy of osteoarthritis (part I) |
| title_sort | molecular basis for new approaches to therapy of osteoarthritis part i |
| topic | osteoarthritis therapy molecular mechanisms stem cells mimetics |
| url | https://mrj.ima-press.net/mrj/article/view/1165 |
| work_keys_str_mv | AT evchetina molecularbasisfornewapproachestotherapyofosteoarthritisparti AT gamarkova molecularbasisfornewapproachestotherapyofosteoarthritisparti AT amlila molecularbasisfornewapproachestotherapyofosteoarthritisparti |