Multifunctional SERS Chip for Biological Application Realized by Double Fano Resonance
The in situ and label-free detection of molecular information in biological cells has always been a challenging problem due to the weak Raman signal of biological molecules. The use of various resonance nanostructures has significantly advanced Surface-enhanced Raman spectroscopy (SERS) in signal en...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-12-01
|
| Series: | Nanomaterials |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-4991/14/24/2036 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850086906291814400 |
|---|---|
| author | Weile Zhu Huiyang Wang Yuheng Wang Shengde Liu Jianglei Di Liyun Zhong |
| author_facet | Weile Zhu Huiyang Wang Yuheng Wang Shengde Liu Jianglei Di Liyun Zhong |
| author_sort | Weile Zhu |
| collection | DOAJ |
| description | The in situ and label-free detection of molecular information in biological cells has always been a challenging problem due to the weak Raman signal of biological molecules. The use of various resonance nanostructures has significantly advanced Surface-enhanced Raman spectroscopy (SERS) in signal enhancement in recent years. However, biological cells are often immersed in different formulations of culture medium with varying refractive indexes and are highly sensitive to the temperature of the microenvironment. This necessitates that SERS meets the requirements of refractive index insensitivity, low thermal damage, broadband enhancement, and other needs in addition to signal enhancement. Here, we propose a SERS chip with integrated dual Fano resonance and the corresponding analytical model. This model can be used to quickly lock the parameters and then analyze the performance of the dual resonance SERS chip. The simulation and experimental characterization results demonstrate that the integrated dual Fano resonances have the ability for independent broadband tuning. This capability enhances both the excitation and radiation processes of Raman signals simultaneously, ensuring that the resonance at the excitation wavelength is not affected by the culture medium (the refractive index) and reduces heat generation. Furthermore, the dual Fano resonance modes can synergize with each other to greatly enhance both the amplitude and enhanced range of the Raman signal, providing a stable, reliable, and comprehensive detection tool and strategy for fingerprint signal detection of bioactive samples. |
| format | Article |
| id | doaj-art-85c35dd31d3d46cd805d17d123ebd1c6 |
| institution | DOAJ |
| issn | 2079-4991 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj-art-85c35dd31d3d46cd805d17d123ebd1c62025-08-20T02:43:20ZengMDPI AGNanomaterials2079-49912024-12-011424203610.3390/nano14242036Multifunctional SERS Chip for Biological Application Realized by Double Fano ResonanceWeile Zhu0Huiyang Wang1Yuheng Wang2Shengde Liu3Jianglei Di4Liyun Zhong5Guangdong Provincial Key Laboratory of Photonics Information Technology, Guangdong University of Technology, Guangzhou 510006, ChinaSchool of Optoelectronic Science and Engineering, South China Normal University, Guangzhou 510006, ChinaSchool of Optoelectronic Science and Engineering, South China Normal University, Guangzhou 510006, ChinaSchool of Optoelectronic Science and Engineering, South China Normal University, Guangzhou 510006, ChinaGuangdong Provincial Key Laboratory of Photonics Information Technology, Guangdong University of Technology, Guangzhou 510006, ChinaGuangdong Provincial Key Laboratory of Photonics Information Technology, Guangdong University of Technology, Guangzhou 510006, ChinaThe in situ and label-free detection of molecular information in biological cells has always been a challenging problem due to the weak Raman signal of biological molecules. The use of various resonance nanostructures has significantly advanced Surface-enhanced Raman spectroscopy (SERS) in signal enhancement in recent years. However, biological cells are often immersed in different formulations of culture medium with varying refractive indexes and are highly sensitive to the temperature of the microenvironment. This necessitates that SERS meets the requirements of refractive index insensitivity, low thermal damage, broadband enhancement, and other needs in addition to signal enhancement. Here, we propose a SERS chip with integrated dual Fano resonance and the corresponding analytical model. This model can be used to quickly lock the parameters and then analyze the performance of the dual resonance SERS chip. The simulation and experimental characterization results demonstrate that the integrated dual Fano resonances have the ability for independent broadband tuning. This capability enhances both the excitation and radiation processes of Raman signals simultaneously, ensuring that the resonance at the excitation wavelength is not affected by the culture medium (the refractive index) and reduces heat generation. Furthermore, the dual Fano resonance modes can synergize with each other to greatly enhance both the amplitude and enhanced range of the Raman signal, providing a stable, reliable, and comprehensive detection tool and strategy for fingerprint signal detection of bioactive samples.https://www.mdpi.com/2079-4991/14/24/2036Raman spectroscopySERSdual Fano resonancesbiological samples |
| spellingShingle | Weile Zhu Huiyang Wang Yuheng Wang Shengde Liu Jianglei Di Liyun Zhong Multifunctional SERS Chip for Biological Application Realized by Double Fano Resonance Nanomaterials Raman spectroscopy SERS dual Fano resonances biological samples |
| title | Multifunctional SERS Chip for Biological Application Realized by Double Fano Resonance |
| title_full | Multifunctional SERS Chip for Biological Application Realized by Double Fano Resonance |
| title_fullStr | Multifunctional SERS Chip for Biological Application Realized by Double Fano Resonance |
| title_full_unstemmed | Multifunctional SERS Chip for Biological Application Realized by Double Fano Resonance |
| title_short | Multifunctional SERS Chip for Biological Application Realized by Double Fano Resonance |
| title_sort | multifunctional sers chip for biological application realized by double fano resonance |
| topic | Raman spectroscopy SERS dual Fano resonances biological samples |
| url | https://www.mdpi.com/2079-4991/14/24/2036 |
| work_keys_str_mv | AT weilezhu multifunctionalserschipforbiologicalapplicationrealizedbydoublefanoresonance AT huiyangwang multifunctionalserschipforbiologicalapplicationrealizedbydoublefanoresonance AT yuhengwang multifunctionalserschipforbiologicalapplicationrealizedbydoublefanoresonance AT shengdeliu multifunctionalserschipforbiologicalapplicationrealizedbydoublefanoresonance AT jiangleidi multifunctionalserschipforbiologicalapplicationrealizedbydoublefanoresonance AT liyunzhong multifunctionalserschipforbiologicalapplicationrealizedbydoublefanoresonance |