Role of PGE2 in Asthma and Nonasthmatic Eosinophilic Bronchitis
Eosinophilic bronchitis is a common cause of chronic cough, which like asthma is characterized by sputum eosinophilia, but unlike asthma there is no variable airflow obstruction or airway hyperresponsiveness. Several studies suggest that prostaglandins may play an important role in orchestrating in...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2012/645383 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849400442778288128 |
|---|---|
| author | Beatriz Sastre Victoria del Pozo |
| author_facet | Beatriz Sastre Victoria del Pozo |
| author_sort | Beatriz Sastre |
| collection | DOAJ |
| description | Eosinophilic bronchitis is a common cause of chronic cough, which like asthma is characterized by sputum eosinophilia, but unlike asthma there is no variable airflow obstruction or airway hyperresponsiveness. Several studies suggest that prostaglandins may play an important role in orchestrating interactions between different cells in several inflammatory diseases such as asthma. PGE2 is important because of the multiplicity of its effects on immune response in respiratory diseases; however, respiratory system appears to be unique in that PGE2 has beneficial effects. We described that the difference in airway function observed in patients with eosinophilic bronchitis and asthma could be due to differences in PGE2 production. PGE2 present in induced sputum supernatant from NAEB patients decreases BSMC proliferation, probably due to simultaneous stimulation of EP2 and EP4 receptors with inhibitory activity. This protective effect of PGE2 may not only be the result of a direct action exerted on airway smooth-muscle proliferation but may also be attributable to the other anti-inflammatory actions. |
| format | Article |
| id | doaj-art-85c30ad2f20e4cbd972c5aff1ef8fa9c |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-85c30ad2f20e4cbd972c5aff1ef8fa9c2025-08-20T03:38:03ZengWileyMediators of Inflammation0962-93511466-18612012-01-01201210.1155/2012/645383645383Role of PGE2 in Asthma and Nonasthmatic Eosinophilic BronchitisBeatriz Sastre0Victoria del Pozo1Immunology Department, IIS-Fundación Jiménez Díaz and CIBER of Respiratory Diseases, 28040 Madrid, SpainImmunology Department, IIS-Fundación Jiménez Díaz and CIBER of Respiratory Diseases, 28040 Madrid, SpainEosinophilic bronchitis is a common cause of chronic cough, which like asthma is characterized by sputum eosinophilia, but unlike asthma there is no variable airflow obstruction or airway hyperresponsiveness. Several studies suggest that prostaglandins may play an important role in orchestrating interactions between different cells in several inflammatory diseases such as asthma. PGE2 is important because of the multiplicity of its effects on immune response in respiratory diseases; however, respiratory system appears to be unique in that PGE2 has beneficial effects. We described that the difference in airway function observed in patients with eosinophilic bronchitis and asthma could be due to differences in PGE2 production. PGE2 present in induced sputum supernatant from NAEB patients decreases BSMC proliferation, probably due to simultaneous stimulation of EP2 and EP4 receptors with inhibitory activity. This protective effect of PGE2 may not only be the result of a direct action exerted on airway smooth-muscle proliferation but may also be attributable to the other anti-inflammatory actions.http://dx.doi.org/10.1155/2012/645383 |
| spellingShingle | Beatriz Sastre Victoria del Pozo Role of PGE2 in Asthma and Nonasthmatic Eosinophilic Bronchitis Mediators of Inflammation |
| title | Role of PGE2 in Asthma and Nonasthmatic Eosinophilic Bronchitis |
| title_full | Role of PGE2 in Asthma and Nonasthmatic Eosinophilic Bronchitis |
| title_fullStr | Role of PGE2 in Asthma and Nonasthmatic Eosinophilic Bronchitis |
| title_full_unstemmed | Role of PGE2 in Asthma and Nonasthmatic Eosinophilic Bronchitis |
| title_short | Role of PGE2 in Asthma and Nonasthmatic Eosinophilic Bronchitis |
| title_sort | role of pge2 in asthma and nonasthmatic eosinophilic bronchitis |
| url | http://dx.doi.org/10.1155/2012/645383 |
| work_keys_str_mv | AT beatrizsastre roleofpge2inasthmaandnonasthmaticeosinophilicbronchitis AT victoriadelpozo roleofpge2inasthmaandnonasthmaticeosinophilicbronchitis |