Mechanobiological Approach for Intestinal Mucosal Immunology
The intestinal area is composed of diverse cell types that harmonize gut homeostasis, which is influenced by both endogenous and exogenous factors. Notably, the environment of the intestine is exposed to several types of mechanical forces, including shear stress generated by fluid flow, compression...
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MDPI AG
2025-01-01
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| author | Hyeyun Kim Se-Hui Lee Jin-Young Yang |
| author_facet | Hyeyun Kim Se-Hui Lee Jin-Young Yang |
| author_sort | Hyeyun Kim |
| collection | DOAJ |
| description | The intestinal area is composed of diverse cell types that harmonize gut homeostasis, which is influenced by both endogenous and exogenous factors. Notably, the environment of the intestine is exposed to several types of mechanical forces, including shear stress generated by fluid flow, compression and stretch generated by luminal contents and peristaltic waves of the intestine, and stiffness attributed to the extracellular matrix. These forces play critical roles in the regulation of cell proliferation, differentiation, and migration. Many efforts have been made to simulate the actual intestinal environment in vitro. The three-dimensional organoid culture system has emerged as a powerful tool for studying the mechanism of the intestinal epithelial barrier, mimicking rapidly renewing epithelium from intestinal stem cells (ISCs) in vivo. However, many aspects of how mechanical forces, such as shear stress, stiffness, compression, and stretch forces, influence the intestinal area remain unresolved. Here, we review the recent studies elucidating the impact of mechanical forces on intestinal immunity, interaction with the gut microbiome, and intestinal diseases. |
| format | Article |
| id | doaj-art-85c1f370fcce4837875f2e5bfe0e12c9 |
| institution | DOAJ |
| issn | 2079-7737 |
| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-85c1f370fcce4837875f2e5bfe0e12c92025-08-20T03:12:05ZengMDPI AGBiology2079-77372025-01-0114211010.3390/biology14020110Mechanobiological Approach for Intestinal Mucosal ImmunologyHyeyun Kim0Se-Hui Lee1Jin-Young Yang2Department of Integrated Biological Science, Pusan National University, Busan 46241, Republic of KoreaDepartment of Integrated Biological Science, Pusan National University, Busan 46241, Republic of KoreaDepartment of Integrated Biological Science, Pusan National University, Busan 46241, Republic of KoreaThe intestinal area is composed of diverse cell types that harmonize gut homeostasis, which is influenced by both endogenous and exogenous factors. Notably, the environment of the intestine is exposed to several types of mechanical forces, including shear stress generated by fluid flow, compression and stretch generated by luminal contents and peristaltic waves of the intestine, and stiffness attributed to the extracellular matrix. These forces play critical roles in the regulation of cell proliferation, differentiation, and migration. Many efforts have been made to simulate the actual intestinal environment in vitro. The three-dimensional organoid culture system has emerged as a powerful tool for studying the mechanism of the intestinal epithelial barrier, mimicking rapidly renewing epithelium from intestinal stem cells (ISCs) in vivo. However, many aspects of how mechanical forces, such as shear stress, stiffness, compression, and stretch forces, influence the intestinal area remain unresolved. Here, we review the recent studies elucidating the impact of mechanical forces on intestinal immunity, interaction with the gut microbiome, and intestinal diseases.https://www.mdpi.com/2079-7737/14/2/110intestinal stem cellsshear stresscompressionstretchstiffnessmechanical stress |
| spellingShingle | Hyeyun Kim Se-Hui Lee Jin-Young Yang Mechanobiological Approach for Intestinal Mucosal Immunology Biology intestinal stem cells shear stress compression stretch stiffness mechanical stress |
| title | Mechanobiological Approach for Intestinal Mucosal Immunology |
| title_full | Mechanobiological Approach for Intestinal Mucosal Immunology |
| title_fullStr | Mechanobiological Approach for Intestinal Mucosal Immunology |
| title_full_unstemmed | Mechanobiological Approach for Intestinal Mucosal Immunology |
| title_short | Mechanobiological Approach for Intestinal Mucosal Immunology |
| title_sort | mechanobiological approach for intestinal mucosal immunology |
| topic | intestinal stem cells shear stress compression stretch stiffness mechanical stress |
| url | https://www.mdpi.com/2079-7737/14/2/110 |
| work_keys_str_mv | AT hyeyunkim mechanobiologicalapproachforintestinalmucosalimmunology AT sehuilee mechanobiologicalapproachforintestinalmucosalimmunology AT jinyoungyang mechanobiologicalapproachforintestinalmucosalimmunology |