The context-dependent epigenetic and organogenesis programs determine 3D vs. 2D cellular fitness of MYC-driven murine liver cancer cells

The context-dependent epigenetic and organogenesis programs determine 3D vs. 2D cellular fitness of MYC-driven murine liver cancer cells

3D cellular-specific epigenetic and transcriptomic reprogramming is critical to organogenesis and tumorigenesis. Here, we dissect the distinct cell fitness in 2D (normoxia vs. chronic hypoxia) vs 3D (normoxia) culture conditions for an MYC-driven murine liver cancer model. We identify over 600 share...

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Main Authors: Jie Fang, Shivendra Singh, Brennan Wells, Qiong Wu, Hongjian Jin, Laura J Janke, Shibiao Wan, Jacob A Steele, Jon P Connelly, Andrew J Murphy, Ruoning Wang, Andrew Davidoff, Margaret Ashcroft, Shondra M Pruett-Miller, Jun Yang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-05-01
Series:eLife
Subjects:
MYC
fitness
hypoxia
CRISPR
3-dimensional
liver cancer
Online Access:https://elifesciences.org/articles/101299
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