Single-cell RNA sequencing reveals transcriptional changes in circulating immune cells from patients with severe asthma induced by biologics

Single-cell RNA sequencing reveals transcriptional changes in circulating immune cells from patients with severe asthma induced by biologics

Abstract Patients with severe eosinophilic asthma often require systemic medication, including corticosteroids and anti-type 2 (T2) cytokine biologics, to control the disease. While anti-IL5 and anti-IL4Rα antibodies suppress the effects of IL-4, IL-5 and IL-13, the molecular pathways modified by th...

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Main Authors: Kyungtaek Park, Ji-Hyang Lee, Eunsoon Shin, Hye Yoon Jang, Woo-Jung Song, Hyouk-Soo Kwon, Yoo Sook Cho, Jong Eun Lee, Ian Adcock, Kian Fan Chung, Jeong Seok Lee, Sungho Won, Tae-Bum Kim
Format: Article
Language:English
Published: Nature Publishing Group 2024-12-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-024-01368-y
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