Immunological mechanism and research progress of peri-implant bone resorption
After implantation of implants as foreign bodies into the jawbone, the immune and skeletal systems of the body regulate and adapt to each other, promoting bone resorption and remodeling around the implants. The imbalance of foreign body response may lead to loss of bone around the implants. This art...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of Oral and Maxillofacial Surgery
2024-12-01
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| Series: | Kouqiang hemian waike zazhi |
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| Online Access: | https://journal06.magtech.org.cn/Jweb_joms/EN/10.12439/kqhm.1005-4979.2024.06.001 |
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| author | HE Yehong FAN Zhen |
| author_facet | HE Yehong FAN Zhen |
| author_sort | HE Yehong |
| collection | DOAJ |
| description | After implantation of implants as foreign bodies into the jawbone, the immune and skeletal systems of the body regulate and adapt to each other, promoting bone resorption and remodeling around the implants. The imbalance of foreign body response may lead to loss of bone around the implants. This article summarizes the relevant factors that may trigger peri-implant immune response and lead to bone resorption, including peri-implant microbial infection, implant overload, poor overall condition, and biological wear of implant materials. Osteoclasts are currently the only known cells in the human body that can cause bone resorption, so their generation has been used as a clue to sort out several key pathways and factors that regulate this process, such as macrophage polarization, receptor activator of nuclear factor-κB ligand (RANKL) / receptor activator of nuclear factor-κB (RANK) / osteoprotegerin (OPG) pathway and nuclear factor-κB (NF-κB) pathway. This review discusses the immune mechanism of peri-implant bone loss, providing insights for understanding the concept of osseointegration and treating peri-implant bone loss from an immune perspective. |
| format | Article |
| id | doaj-art-85b1c9c6c6ec4e4f803663c83ffa9dcf |
| institution | Kabale University |
| issn | 1005-4979 |
| language | zho |
| publishDate | 2024-12-01 |
| publisher | Editorial Office of Journal of Oral and Maxillofacial Surgery |
| record_format | Article |
| series | Kouqiang hemian waike zazhi |
| spelling | doaj-art-85b1c9c6c6ec4e4f803663c83ffa9dcf2025-08-25T06:11:31ZzhoEditorial Office of Journal of Oral and Maxillofacial SurgeryKouqiang hemian waike zazhi1005-49792024-12-0134641342010.12439/kqhm.1005-4979.2024.06.001Immunological mechanism and research progress of peri-implant bone resorptionHE Yehong0FAN Zhen1Shanghai Engineering Research Center of Tooth Restoration and Regeneration & Tongji Research Institute of Stomatology & Department of Oral Implantology, Shanghai Tongji Stomatological Hospital and Dental School, Tongji University, Shanghai 200072, ChinaShanghai Engineering Research Center of Tooth Restoration and Regeneration & Tongji Research Institute of Stomatology & Department of Oral Implantology, Shanghai Tongji Stomatological Hospital and Dental School, Tongji University, Shanghai 200072, ChinaAfter implantation of implants as foreign bodies into the jawbone, the immune and skeletal systems of the body regulate and adapt to each other, promoting bone resorption and remodeling around the implants. The imbalance of foreign body response may lead to loss of bone around the implants. This article summarizes the relevant factors that may trigger peri-implant immune response and lead to bone resorption, including peri-implant microbial infection, implant overload, poor overall condition, and biological wear of implant materials. Osteoclasts are currently the only known cells in the human body that can cause bone resorption, so their generation has been used as a clue to sort out several key pathways and factors that regulate this process, such as macrophage polarization, receptor activator of nuclear factor-κB ligand (RANKL) / receptor activator of nuclear factor-κB (RANK) / osteoprotegerin (OPG) pathway and nuclear factor-κB (NF-κB) pathway. This review discusses the immune mechanism of peri-implant bone loss, providing insights for understanding the concept of osseointegration and treating peri-implant bone loss from an immune perspective.https://journal06.magtech.org.cn/Jweb_joms/EN/10.12439/kqhm.1005-4979.2024.06.001dental implantbone resorptionosteoimmunologyosseointegration |
| spellingShingle | HE Yehong FAN Zhen Immunological mechanism and research progress of peri-implant bone resorption Kouqiang hemian waike zazhi dental implant bone resorption osteoimmunology osseointegration |
| title | Immunological mechanism and research progress of peri-implant bone resorption |
| title_full | Immunological mechanism and research progress of peri-implant bone resorption |
| title_fullStr | Immunological mechanism and research progress of peri-implant bone resorption |
| title_full_unstemmed | Immunological mechanism and research progress of peri-implant bone resorption |
| title_short | Immunological mechanism and research progress of peri-implant bone resorption |
| title_sort | immunological mechanism and research progress of peri implant bone resorption |
| topic | dental implant bone resorption osteoimmunology osseointegration |
| url | https://journal06.magtech.org.cn/Jweb_joms/EN/10.12439/kqhm.1005-4979.2024.06.001 |
| work_keys_str_mv | AT heyehong immunologicalmechanismandresearchprogressofperiimplantboneresorption AT fanzhen immunologicalmechanismandresearchprogressofperiimplantboneresorption |