Neutrophil-to-lymphocyte ratio: association with microcirculatory changes detected by nailfold capillaroscopy in scleroderma patients and its relation to disease severity
Abstract Background Microvascular alteration in scleroderma patients is well documented. Microcirculatory changes can be visualized by nailfold capillary microscopy (NFC) examination which is a safe and noninvasive technique. This study aims to identify possible association between neutrophil-to-lym...
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2025-01-01
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| Series: | Egyptian Rheumatology and Rehabilitation |
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| Online Access: | https://doi.org/10.1186/s43166-024-00299-w |
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| author | Rasha M. Hammoda Nermin H. El-Gharbawy Ahmed A. Khalifa Amira A. Moharram Rahma A. Elziaty |
| author_facet | Rasha M. Hammoda Nermin H. El-Gharbawy Ahmed A. Khalifa Amira A. Moharram Rahma A. Elziaty |
| author_sort | Rasha M. Hammoda |
| collection | DOAJ |
| description | Abstract Background Microvascular alteration in scleroderma patients is well documented. Microcirculatory changes can be visualized by nailfold capillary microscopy (NFC) examination which is a safe and noninvasive technique. This study aims to identify possible association between neutrophil-to-lymphocyte ratio (NLR) and microvascular changes detected by nailfold capillaroscopic examination in scleroderma patients. Results The study was conducted on 25 patients with systemic sclerosis. On studying the correlation of NLR with laboratory parameters, we found significant positive correlations with erythrocyte sedimentation rate “ESR” and C-reactive protein “CRP” values (p = 0.000). Regarding the clinical manifestations, higher NLR was significantly related to the presence of digital ulcer (p = 0.023) and Raynaud’s phenomenon (p = 0.015). There was significantly negative relation between NLR with cyclophosphamide treatment. Regarding NFC examination’s results, there was significant negative correlation of NLR with capillary number/mm (p = 0.000) and significant positive correlation of NLR with capillary width (p = 0.005), and a significant relation of NLR with the presence of capillary hemorrhage and presence of active scleroderma pattern (p = 0.010) was also reported. Conclusion High N/L ratio as a marker of inflammation was found to reflect severity of systemic sclerosis and is associated with larger capillary diameter and lower capillary number in nailfold capillaroscopy. Active scleroderma pattern was associated with high N/L ratio. Further longitudinal studies are needed to determine the frequency of nailfold videocapillaroscopy and N/L ratio. |
| format | Article |
| id | doaj-art-85ad499d210443dda01d877b8649416f |
| institution | Kabale University |
| issn | 2090-3235 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Rheumatology and Rehabilitation |
| spelling | doaj-art-85ad499d210443dda01d877b8649416f2025-01-19T12:26:27ZengSpringerOpenEgyptian Rheumatology and Rehabilitation2090-32352025-01-015211910.1186/s43166-024-00299-wNeutrophil-to-lymphocyte ratio: association with microcirculatory changes detected by nailfold capillaroscopy in scleroderma patients and its relation to disease severityRasha M. Hammoda0Nermin H. El-Gharbawy1Ahmed A. Khalifa2Amira A. Moharram3Rahma A. Elziaty4Department of Internal Medicine, Rheumatology Division, Faculty of Medicine, Ain Shams UniversityDepartment of Rheumatology and Rehabilitation, Faculty of Medicine, Ain Shams UniversityDepartment of Internal Medicine, Rheumatology Division, Faculty of Medicine, Ain Shams UniversityDepartment of Clinical Pathology, Faculty of Medicine, Ain Shams UniversityDepartment of Internal Medicine, Rheumatology Division, Faculty of Medicine, Ain Shams UniversityAbstract Background Microvascular alteration in scleroderma patients is well documented. Microcirculatory changes can be visualized by nailfold capillary microscopy (NFC) examination which is a safe and noninvasive technique. This study aims to identify possible association between neutrophil-to-lymphocyte ratio (NLR) and microvascular changes detected by nailfold capillaroscopic examination in scleroderma patients. Results The study was conducted on 25 patients with systemic sclerosis. On studying the correlation of NLR with laboratory parameters, we found significant positive correlations with erythrocyte sedimentation rate “ESR” and C-reactive protein “CRP” values (p = 0.000). Regarding the clinical manifestations, higher NLR was significantly related to the presence of digital ulcer (p = 0.023) and Raynaud’s phenomenon (p = 0.015). There was significantly negative relation between NLR with cyclophosphamide treatment. Regarding NFC examination’s results, there was significant negative correlation of NLR with capillary number/mm (p = 0.000) and significant positive correlation of NLR with capillary width (p = 0.005), and a significant relation of NLR with the presence of capillary hemorrhage and presence of active scleroderma pattern (p = 0.010) was also reported. Conclusion High N/L ratio as a marker of inflammation was found to reflect severity of systemic sclerosis and is associated with larger capillary diameter and lower capillary number in nailfold capillaroscopy. Active scleroderma pattern was associated with high N/L ratio. Further longitudinal studies are needed to determine the frequency of nailfold videocapillaroscopy and N/L ratio.https://doi.org/10.1186/s43166-024-00299-wSclerodermaNLR ratioCapillaroscopy |
| spellingShingle | Rasha M. Hammoda Nermin H. El-Gharbawy Ahmed A. Khalifa Amira A. Moharram Rahma A. Elziaty Neutrophil-to-lymphocyte ratio: association with microcirculatory changes detected by nailfold capillaroscopy in scleroderma patients and its relation to disease severity Egyptian Rheumatology and Rehabilitation Scleroderma NLR ratio Capillaroscopy |
| title | Neutrophil-to-lymphocyte ratio: association with microcirculatory changes detected by nailfold capillaroscopy in scleroderma patients and its relation to disease severity |
| title_full | Neutrophil-to-lymphocyte ratio: association with microcirculatory changes detected by nailfold capillaroscopy in scleroderma patients and its relation to disease severity |
| title_fullStr | Neutrophil-to-lymphocyte ratio: association with microcirculatory changes detected by nailfold capillaroscopy in scleroderma patients and its relation to disease severity |
| title_full_unstemmed | Neutrophil-to-lymphocyte ratio: association with microcirculatory changes detected by nailfold capillaroscopy in scleroderma patients and its relation to disease severity |
| title_short | Neutrophil-to-lymphocyte ratio: association with microcirculatory changes detected by nailfold capillaroscopy in scleroderma patients and its relation to disease severity |
| title_sort | neutrophil to lymphocyte ratio association with microcirculatory changes detected by nailfold capillaroscopy in scleroderma patients and its relation to disease severity |
| topic | Scleroderma NLR ratio Capillaroscopy |
| url | https://doi.org/10.1186/s43166-024-00299-w |
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