Neutrophil extracellular traps and echogenicity of carotid atherosclerotic plaques
Aim. To study the association between the number of neutrophil extracellular traps (NETs) formed by circulating neutrophils and echogenicity of carotid atherosclerotic plaques. Materials and Methods. We enrolled 72 patients (40-64 years of age) without the clinical signs of atherosclerotic vascular...
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| Format: | Article |
| Language: | Russian |
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Kemerovo State Medical University
2020-12-01
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| Series: | Фундаментальная и клиническая медицина |
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| Online Access: | https://fcm.kemsmu.ru/jour/article/view/334 |
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| author | I. I. Dolgushin V. V. Genkel A. Y. Savochkina I. V. Samuseva I. L. Baturina M. A. Zotova I. V. Emelyanov A. S. Kuznetsova |
| author_facet | I. I. Dolgushin V. V. Genkel A. Y. Savochkina I. V. Samuseva I. L. Baturina M. A. Zotova I. V. Emelyanov A. S. Kuznetsova |
| author_sort | I. I. Dolgushin |
| collection | DOAJ |
| description | Aim. To study the association between the number of neutrophil extracellular traps (NETs) formed by circulating neutrophils and echogenicity of carotid atherosclerotic plaques. Materials and Methods. We enrolled 72 patients (40-64 years of age) without the clinical signs of atherosclerotic vascular disease, who then underwent ultrasound duplex scanning of carotid arteries. Grayscale median analysis of the images was performed using Adobe Photoshop CS6 software. Neutrophils were stained and examined by means of light microscopy to count NETs. Results. Carotid atherosclerotic plaques were found in 69.4% of asymptomatic patients. Echogenicity of atherosclerotic plaques inversely correlated with the number of NETs (r = - 0.310; p = 0.029). The number of NETs in patients with echolucent plaques (GSM < 60) was significantly higher in comparison with echogenic plaques (GSM ≥ 60, p = 0.042). |
| format | Article |
| id | doaj-art-85aa3b2b0dd742d59aa951a0820042c8 |
| institution | Kabale University |
| issn | 2500-0764 2542-0941 |
| language | Russian |
| publishDate | 2020-12-01 |
| publisher | Kemerovo State Medical University |
| record_format | Article |
| series | Фундаментальная и клиническая медицина |
| spelling | doaj-art-85aa3b2b0dd742d59aa951a0820042c82025-08-20T03:42:38ZrusKemerovo State Medical UniversityФундаментальная и клиническая медицина2500-07642542-09412020-12-0154576410.23946/2500-0764-2020-5-4-57-64229Neutrophil extracellular traps and echogenicity of carotid atherosclerotic plaquesI. I. Dolgushin0V. V. Genkel1A. Y. Savochkina2I. V. Samuseva3I. L. Baturina4M. A. Zotova5I. V. Emelyanov6A. S. Kuznetsova7South Ural State Medical UniversitSouth Ural State Medical UniversitSouth Ural State Medical UniversitSouth Ural State Medical UniversitSouth Ural State Medical UniversitSouth Ural State Medical UniversitSouth Ural State Medical UniversitSouth Ural State Medical UniversitAim. To study the association between the number of neutrophil extracellular traps (NETs) formed by circulating neutrophils and echogenicity of carotid atherosclerotic plaques. Materials and Methods. We enrolled 72 patients (40-64 years of age) without the clinical signs of atherosclerotic vascular disease, who then underwent ultrasound duplex scanning of carotid arteries. Grayscale median analysis of the images was performed using Adobe Photoshop CS6 software. Neutrophils were stained and examined by means of light microscopy to count NETs. Results. Carotid atherosclerotic plaques were found in 69.4% of asymptomatic patients. Echogenicity of atherosclerotic plaques inversely correlated with the number of NETs (r = - 0.310; p = 0.029). The number of NETs in patients with echolucent plaques (GSM < 60) was significantly higher in comparison with echogenic plaques (GSM ≥ 60, p = 0.042).https://fcm.kemsmu.ru/jour/article/view/334atherosclerotic plaquesgrayscale median analysisneutrophil extracellular traps |
| spellingShingle | I. I. Dolgushin V. V. Genkel A. Y. Savochkina I. V. Samuseva I. L. Baturina M. A. Zotova I. V. Emelyanov A. S. Kuznetsova Neutrophil extracellular traps and echogenicity of carotid atherosclerotic plaques Фундаментальная и клиническая медицина atherosclerotic plaques grayscale median analysis neutrophil extracellular traps |
| title | Neutrophil extracellular traps and echogenicity of carotid atherosclerotic plaques |
| title_full | Neutrophil extracellular traps and echogenicity of carotid atherosclerotic plaques |
| title_fullStr | Neutrophil extracellular traps and echogenicity of carotid atherosclerotic plaques |
| title_full_unstemmed | Neutrophil extracellular traps and echogenicity of carotid atherosclerotic plaques |
| title_short | Neutrophil extracellular traps and echogenicity of carotid atherosclerotic plaques |
| title_sort | neutrophil extracellular traps and echogenicity of carotid atherosclerotic plaques |
| topic | atherosclerotic plaques grayscale median analysis neutrophil extracellular traps |
| url | https://fcm.kemsmu.ru/jour/article/view/334 |
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