Evaluation of magnetic resonance thermometry performance during MR-guided hyperthermia treatment of soft-tissue sarcomas in the lower extremities and pelvis
Introduction This study evaluated the performance of magnetic resonance thermometry (MRT) during deep-regional hyperthermia (HT) in pelvic and lower-extremity soft-tissue sarcomas.Materials and methods 17 pelvic (45 treatments) and 16 lower-extremity (42 treatments) patients underwent standard regio...
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Taylor & Francis Group
2024-12-01
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| Series: | International Journal of Hyperthermia |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2024.2405105 |
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| author | Spyridon N. Karkavitsas Marianne Göger-Neff Maria Kawula Kemal Sumser Benjamin Zilles Martin Wadepohl Guillaume Landry Christopher Kurz Wolfgang G. Kunz Olaf Dietrich Lars H. Lindner Margarethus M. Paulides |
| author_facet | Spyridon N. Karkavitsas Marianne Göger-Neff Maria Kawula Kemal Sumser Benjamin Zilles Martin Wadepohl Guillaume Landry Christopher Kurz Wolfgang G. Kunz Olaf Dietrich Lars H. Lindner Margarethus M. Paulides |
| author_sort | Spyridon N. Karkavitsas |
| collection | DOAJ |
| description | Introduction This study evaluated the performance of magnetic resonance thermometry (MRT) during deep-regional hyperthermia (HT) in pelvic and lower-extremity soft-tissue sarcomas.Materials and methods 17 pelvic (45 treatments) and 16 lower-extremity (42 treatments) patients underwent standard regional HT and chemotherapy. Pairs of double-echo gradient-echo scans were acquired during the MR protocol 1.4 s apart. For each pair, precision was quantified using phase data from both echoes (‘dual-echo’) or only one (‘single-echo’) in- or excluding body fat pixels in the field drift correction region of interest. The precision of each method was compared to that of the MRT approach using a built-in clinical software tool (SigmaVision). Accuracy was assessed in three lower-extremity patients (six treatments) using interstitial temperature probes. The Jaccard coefficient quantified pretreatment motion; receiver operating characteristic analysis assessed its predictability for acceptable precision (<1 °C) during HT.Results Compared to the built-in dual-echo approach, single-echo thermometry improved the mean temporal precision from 1.32 ± 0.40 °C to 1.07 ± 0.34 °C (pelvis) and from 0.99 ± 0.28 °C to 0.76 ± 0.23 °C (lower extremities). With body fat-based field drift correction, single-echo mean accuracy improved from 1.4 °C to 1.0 °C. Pretreatment bulk motion provided excellent precision prediction with an area under the curve of 0.80–0.86 (pelvis) and 0.81–0.83 (lower extremities), compared to gastrointestinal air motion (0.52–0.58).Conclusion Single-echo MRT exhibited better precision than dual-echo MRT. Body fat-based field-drift correction significantly improved MRT accuracy. Pretreatment bulk motion showed improved prediction of acceptable MRT temporal precision over gastrointestinal air motion. |
| format | Article |
| id | doaj-art-85a9921f4260473fa1a5c85f6e724e14 |
| institution | Kabale University |
| issn | 0265-6736 1464-5157 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj-art-85a9921f4260473fa1a5c85f6e724e142025-01-03T09:30:27ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572024-12-0141110.1080/02656736.2024.2405105Evaluation of magnetic resonance thermometry performance during MR-guided hyperthermia treatment of soft-tissue sarcomas in the lower extremities and pelvisSpyridon N. Karkavitsas0Marianne Göger-Neff1Maria Kawula2Kemal Sumser3Benjamin Zilles4Martin Wadepohl5Guillaume Landry6Christopher Kurz7Wolfgang G. Kunz8Olaf Dietrich9Lars H. Lindner10Margarethus M. Paulides11Department of Medicine III, LMU University Hospital, LMU Munich, Munich, GermanyDepartment of Medicine III, LMU University Hospital, LMU Munich, Munich, GermanyDepartment of Radiation Oncology, LMU University Hospital, LMU Munich, Munich, GermanyCare + Cure lab of the Electromagnetics group (EM4C + C), Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, The NetherlandsDepartment of Medicine III, LMU University Hospital, LMU Munich, Munich, GermanyDr. Sennewald Medizintechnik GmbH, Munich, GermanyDepartment of Radiation Oncology, LMU University Hospital, LMU Munich, Munich, GermanyDepartment of Radiation Oncology, LMU University Hospital, LMU Munich, Munich, GermanyDepartment of Radiology, LMU University Hospital, LMU Munich, Munich, GermanyDepartment of Radiology, LMU University Hospital, LMU Munich, Munich, GermanyDepartment of Medicine III, LMU University Hospital, LMU Munich, Munich, GermanyCare + Cure lab of the Electromagnetics group (EM4C + C), Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, The NetherlandsIntroduction This study evaluated the performance of magnetic resonance thermometry (MRT) during deep-regional hyperthermia (HT) in pelvic and lower-extremity soft-tissue sarcomas.Materials and methods 17 pelvic (45 treatments) and 16 lower-extremity (42 treatments) patients underwent standard regional HT and chemotherapy. Pairs of double-echo gradient-echo scans were acquired during the MR protocol 1.4 s apart. For each pair, precision was quantified using phase data from both echoes (‘dual-echo’) or only one (‘single-echo’) in- or excluding body fat pixels in the field drift correction region of interest. The precision of each method was compared to that of the MRT approach using a built-in clinical software tool (SigmaVision). Accuracy was assessed in three lower-extremity patients (six treatments) using interstitial temperature probes. The Jaccard coefficient quantified pretreatment motion; receiver operating characteristic analysis assessed its predictability for acceptable precision (<1 °C) during HT.Results Compared to the built-in dual-echo approach, single-echo thermometry improved the mean temporal precision from 1.32 ± 0.40 °C to 1.07 ± 0.34 °C (pelvis) and from 0.99 ± 0.28 °C to 0.76 ± 0.23 °C (lower extremities). With body fat-based field drift correction, single-echo mean accuracy improved from 1.4 °C to 1.0 °C. Pretreatment bulk motion provided excellent precision prediction with an area under the curve of 0.80–0.86 (pelvis) and 0.81–0.83 (lower extremities), compared to gastrointestinal air motion (0.52–0.58).Conclusion Single-echo MRT exhibited better precision than dual-echo MRT. Body fat-based field-drift correction significantly improved MRT accuracy. Pretreatment bulk motion showed improved prediction of acceptable MRT temporal precision over gastrointestinal air motion.https://www.tandfonline.com/doi/10.1080/02656736.2024.2405105MR thermometryPRFSaccuracyprecisionmotion-dependenceautomatic segmentation |
| spellingShingle | Spyridon N. Karkavitsas Marianne Göger-Neff Maria Kawula Kemal Sumser Benjamin Zilles Martin Wadepohl Guillaume Landry Christopher Kurz Wolfgang G. Kunz Olaf Dietrich Lars H. Lindner Margarethus M. Paulides Evaluation of magnetic resonance thermometry performance during MR-guided hyperthermia treatment of soft-tissue sarcomas in the lower extremities and pelvis International Journal of Hyperthermia MR thermometry PRFS accuracy precision motion-dependence automatic segmentation |
| title | Evaluation of magnetic resonance thermometry performance during MR-guided hyperthermia treatment of soft-tissue sarcomas in the lower extremities and pelvis |
| title_full | Evaluation of magnetic resonance thermometry performance during MR-guided hyperthermia treatment of soft-tissue sarcomas in the lower extremities and pelvis |
| title_fullStr | Evaluation of magnetic resonance thermometry performance during MR-guided hyperthermia treatment of soft-tissue sarcomas in the lower extremities and pelvis |
| title_full_unstemmed | Evaluation of magnetic resonance thermometry performance during MR-guided hyperthermia treatment of soft-tissue sarcomas in the lower extremities and pelvis |
| title_short | Evaluation of magnetic resonance thermometry performance during MR-guided hyperthermia treatment of soft-tissue sarcomas in the lower extremities and pelvis |
| title_sort | evaluation of magnetic resonance thermometry performance during mr guided hyperthermia treatment of soft tissue sarcomas in the lower extremities and pelvis |
| topic | MR thermometry PRFS accuracy precision motion-dependence automatic segmentation |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2024.2405105 |
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