Breaching the Barrier: Investigating Initial Herpes Simplex Viral Infection and Spread in Human Skin and Mucosa

Breaching the Barrier: Investigating Initial Herpes Simplex Viral Infection and Spread in Human Skin and Mucosa

Herpes simplex virus (HSV) is sexually transmitted via the anogenital mucosa where it initially infects epidermal keratinocytes and mononuclear phagocytes (MNPs). It then spreads to the dorsal root ganglion via sensory nerve endings, to remain latent for life with periodic reactivation. Currently, t...

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Bibliographic Details
Main Authors: Hafsa Rana, Naomi R. Truong, Dona R. Sirimanne, Anthony L. Cunningham
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Viruses
Subjects:
herpes simplex virus
skin
genital mucosa
viral spread
keratinocytes
dendritic cells
Online Access:https://www.mdpi.com/1999-4915/16/11/1790
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