Patients outcomes in lung adenocarcinoma transforming to small-cell lung cancer after tyrosine kinase inhibitor therapy

Patients outcomes in lung adenocarcinoma transforming to small-cell lung cancer after tyrosine kinase inhibitor therapy

Abstract Background Non-small cell lung cancer (NSCLC) transforming to small cell lung cancer (SCLC) is one of the mechanisms of resistance to tyrosine kinase inhibitors (TKIs). Cases of NSCLC transforming into SCLC have been discovered. However, we lack concentrated data on the characteristics of t...

Full description

Saved in:

Bibliographic Details
Main Authors:	Shuai Wang, Yongsen Wang, Xuan Wu, Li Yang, Xiaoju Zhang
Format:	Article
Language:	English
Published:	BMC 2025-02-01
Series:	World Journal of Surgical Oncology
Subjects:	Non-small cell lung cancer Transformation Small cell lung cancer TKIs Resistance
Online Access:	https://doi.org/10.1186/s12957-025-03687-4
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

A Case of Primary Lung Adenocarcinoma With Recurrent Brain Metastasis due to Transformation to Small Cell Carcinoma During Adjuvant Atezolizumab Therapy
by: Nao Kobayashi, et al.
Published: (2025-01-01)

Association of whole grain food consumption with lung cancer risk: a prospective cohort study
by: Kanran Wang, et al.
Published: (2025-01-01)

Molecular landscape of lung cancer: insights into therapeutic targets and clinical outcomes
by: Saloni Mangal, et al.
Published: (2024-12-01)

Evaluation of EGFR-TKIs and ICIs treatment stratification in non-small cell lung cancer using an encrypted multidimensional radiomics approach
by: Xingping Zhang, et al.
Published: (2025-01-01)

Remarkable response to low dose of selpercatinib in a patient with RET-rearranged non-small cell lung cancer
by: Jun Sakakibara-Konishi, et al.
Published: (2025-01-01)

PARP inhibitors as therapy for small cell lung carcinoma: A systematic review and meta-analysis of clinical trials
by: Samuel Pratama, et al.
Published: (2024-01-01)

Trends in Real-World Clinical Outcomes of Patients with Anaplastic Lymphoma Kinase (ALK) Rearranged Non-Small Cell Lung Cancer (NSCLC) Receiving One or More ALK Tyrosine Kinase Inhibitors (TKIs): A Cohort Study in Ontario, Canada
by: Lara Chayab, et al.
Published: (2024-12-01)

Rosavin exerts an antitumor role and inactivates the MAPK/ERK pathway in small-cell lung carcinoma in vitro
by: Liu Rui, et al.
Published: (2023-06-01)

LncRNA MANCR is downregulated in non-small cell lung cancer and predicts poor survival
by: Yunming Tao, et al.
Published: (2025-01-01)

Klinefelter syndrome diagnosed at autopsy and small-cell lung carcinoma
by: Haruyasu Sakuranaka, et al.
Published: (2025-01-01)

Diagnosis of lung cancer using salivary miRNAs expression and clinical characteristics
by: Negar Alizadeh, et al.
Published: (2025-01-01)

Composition of the sputum bacterial microbiome of patients with different pathomorphological forms of non-small-cell lung cancer
by: V. G. Druzhinin, et al.
Published: (2024-04-01)

PAX6 enhances Nanog expression by inhibiting NOTCH signaling to promote malignant properties in small cell lung cancer cells
by: Xiao-Fang Guo, et al.
Published: (2025-01-01)

Survival outcomes of surgery and adjuvant chemotherapy in early-stage small cell and large cell lung cancer: a novel focus on tumors less than 1 cm
by: Jorge Raul Vazquez-Urrutia, et al.
Published: (2025-01-01)

The role of radiotherapy in small cell lung cancer: a new paradigm for the radiation oncologist
by: Paolo Borghetti, et al.
Published: (2025-01-01)

Non-small cell lung cancer and the tumor microenvironment: making headway from targeted therapies to advanced immunotherapy
by: Anna De Lucia, et al.
Published: (2025-02-01)

Epsin3 promotes non-small cell lung cancer progression via modulating EGFR stability
by: Huiling Su, et al.
Published: (2025-02-01)

Predictive Value of Initial 18F-FDG PET/CT for Identifying EGFR and KRAS Mutations in Patients with Non-small-cell Lung Cancer
by: Ozge Vural Topuz, et al.
Published: (2024-11-01)

The impact of KRAS mutations on the tumour microenvironment and treatment response in non-small cell lung cancer
by: Guomin Gu, et al.
Published: (2024-12-01)

Comparative safety profile of tyrosine kinase inhibitors in NSCLC: a network meta-analysis of hypertension and thrombotic risks
by: Mingming Tan, et al.
Published: (2025-01-01)

Machine learning insights into early mortality risks for small cell lung cancer patients post-chemotherapy
by: Min Liang, et al.
Published: (2025-01-01)

Small cell lung cancer with EML4-ALK fusion: report of a case responding to ALK TKI and literature review
by: Mingyue Wang, et al.
Published: (2025-02-01)

Neoadjuvant programmed death ligand-1 with chemotherapy versus chemotherapy alone for limited-stage small-cell lung cancer: a retrospective study
by: Zhi Yang, et al.
Published: (2025-01-01)

Treatment Options for Advanced Non-Small Cell Lung Cancer After Failure of Previous Immune Checkpoint Inhibitors and Chemotherapy: Meta-Analysis of Five Randomized Controlled Trials
by: Andrea Messori, et al.
Published: (2025-01-01)

Phase Ib/II study on the safety, tolerability, and preliminary efficacy of pegylated irinotecan (JK1201I) as second‐line monotherapy for patients with small‐cell lung cancer
by: Jieran Long, et al.
Published: (2024-09-01)

Efficacy of PD-1 blockade plus chemotherapy in patients with oncogenic-driven non-small-cell lung cancer
by: Haowei Wang, et al.
Published: (2025-02-01)

Development and validation of a predictive model for lymph node metastases in peripheral non-small cell lung cancer with a tumor diameter ≤ 2.0 cm and a consolidation-to-tumor ratio > 0.5
by: Dongyu Li, et al.
Published: (2025-01-01)

Perioperative or neo/adjuvant chemoimmunotherapy versus chemotherapy for resectable non-small cell lung cancer: a systematic review and network meta-analysis
by: Qiong Zhang, et al.
Published: (2025-01-01)

Brief report: impact of consolidation durvalumab on unresectable non-small cell lung cancer with driver mutations
by: Jason C.S. Ho, et al.
Published: (2024-01-01)

The Treatment Effect of Plantago Major on Lung Cancer Based on the Computed Tomography and Pathological Findings: A Case Report Study
by: Saade Abdalkareem Jasim, et al.
Published: (2025-01-01)

Artificial neural network systems to predict the response to sintilimab in squamous-cell non-small-cell lung cancer based on data of ORIENT-3 study
by: Tongji Xie, et al.
Published: (2024-12-01)

Previous treatment decreases efficacy of pralsetinib in RET fusion-positive non-small-cell lung cancer
by: Lei Wang, et al.
Published: (2025-01-01)

Comparison of the Efficacy and Safety of PD‐1/PD‐L1 Inhibitors in the Treatment of Small Cell Lung Cancer
by: Qichen Zhang, et al.
Published: (2025-01-01)

Prognostic value of the lactate dehydrogenase to albumin ratio in advanced non-small cell lung cancer patients treated with the first-line PD-1 checkpoint inhibitors combined with chemotherapy
by: Meifeng Luo, et al.
Published: (2025-02-01)

Ginseng polysaccharides circumvent acquired resistance to anti-PD-1 immunotherapy in patients with non-small cell lung cancer
by: Jumin Huang, et al.
Published: (2025-02-01)

Comparing survival outcomes of localized tumor destruction, sublobar resection, and pulmonary lobectomy in stage IA non-small cell lung cancer: a study from the SEER database
by: Lin Cheng, et al.
Published: (2025-02-01)

Multi-omics analysis reveals the sensitivity of immunotherapy for unresectable non-small cell lung cancer
by: Rui Wu, et al.
Published: (2025-02-01)

Prognosis of nodal micrometastasis in resectable pN0 non-small cell lung cancer
by: Sophon Siwachat, et al.
Published: (2025-01-01)

The Role of Pentacyclic Triterpenoids in Non-Small Cell Lung Cancer: The Mechanisms of Action and Therapeutic Potential
by: Young-Shin Lee, et al.
Published: (2024-12-01)

Experimental approach to obtaining subcutaneous xenograft of non-small cell lung cancer
by: E. A. Lukbanova, et al.
Published: (2022-06-01)