The role of protein phosphorylation modifications mediated by iron metabolism regulatory networks in the pathogenesis of Alzheimer’s disease

The role of protein phosphorylation modifications mediated by iron metabolism regulatory networks in the pathogenesis of Alzheimer’s disease

Alzheimer’s disease (AD) is a severe neurodegenerative disease characterized mainly by the formation of amyloid beta (Aβ) plaques and abnormal phosphorylation of tau. In recent years, an imbalance in iron homeostasis has been recognized to play a key role in the pathological process of AD. Abnormal...

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Bibliographic Details
Main Authors: Fei-Xiang Liu, Shun-Zhi Yang, Kai-Kai Shi, Ding-Ming Li, Jia-bin Song, Lu Sun, Xue Dang, Jin-Yao Li, Zi-qi Deng, Min Zhao, Yan-Chen Feng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Aging Neuroscience
Subjects:
iron
iron metabolism
protein phosphorylation
Alzheimer’s disease
post-translational modification of proteins
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2025.1540019/full
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