1,2-Dihydroxy-<i>9H</i>-Xanthen-9-One, a Multifunctional Nature-Inspired Active Ingredient
Incorporating antioxidants into cosmetics is the mainstay for developing new products to mitigate skin aging. However, identifying novel multifunctional antioxidant ingredients with additional relevant properties that block the skin hallmarks of aging is a very striking strategy. Many natural compou...
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| Format: | Article |
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MDPI AG
2024-12-01
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| Series: | Cosmetics |
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| Online Access: | https://www.mdpi.com/2079-9284/11/6/215 |
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| author | Ana Jesus Sara F. Vieira Gonçalo Brites Mylène Carrascal Helena Ferreira Nuno M. Neves Honorina Cidade Madalena Pinto Emília Sousa Isabel F. Almeida Maria T. Cruz |
| author_facet | Ana Jesus Sara F. Vieira Gonçalo Brites Mylène Carrascal Helena Ferreira Nuno M. Neves Honorina Cidade Madalena Pinto Emília Sousa Isabel F. Almeida Maria T. Cruz |
| author_sort | Ana Jesus |
| collection | DOAJ |
| description | Incorporating antioxidants into cosmetics is the mainstay for developing new products to mitigate skin aging. However, identifying novel multifunctional antioxidant ingredients with additional relevant properties that block the skin hallmarks of aging is a very striking strategy. Many natural compounds, including xanthones, have demonstrated biologically notable properties. In particular, 1,2-dihydroxy-9<i>H</i>-xanthen-9-one (1,2-DHX) has inhibitory activity against skin enzymes, and metal-chelating and radical-scavenging activities. Therefore, 1,2-DHX is an attractive molecule for cosmetic purposes. With this goal in mind, the anti-inflammatory, antioxidant, and anti-allergic potentials of 1,2-DHX were investigated. 1,2-DHX demonstrated anti-inflammatory properties by inhibiting the synthesis of specific pro-inflammatory mediators, including interleukin-6 (IL-6) and prostaglandin E2 (PGE2), in human macrophages. This xanthone did not elicit sensitization reactions and did inhibit allergic reactions triggered by a strong skin allergen, suggesting its potential as an anti-allergic compound. 1,2-DHX also revealed mitochondrial antioxidant activity by mitigating rotenone-induced oxidative stress in macrophages by up to 40%. Overall, 1,2-DHX displayed a safety profile and noteworthy biological activities, highlighting its multifunctional profile as an active cosmetic ingredient with anti-inflammatory, antioxidant, and anti-allergic properties. |
| format | Article |
| id | doaj-art-85a61fe9bc9c4d48a87bf2ca7eb5d707 |
| institution | DOAJ |
| issn | 2079-9284 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cosmetics |
| spelling | doaj-art-85a61fe9bc9c4d48a87bf2ca7eb5d7072025-08-20T02:55:45ZengMDPI AGCosmetics2079-92842024-12-0111621510.3390/cosmetics110602151,2-Dihydroxy-<i>9H</i>-Xanthen-9-One, a Multifunctional Nature-Inspired Active IngredientAna Jesus0Sara F. Vieira1Gonçalo Brites2Mylène Carrascal3Helena Ferreira4Nuno M. Neves5Honorina Cidade6Madalena Pinto7Emília Sousa8Isabel F. Almeida9Maria T. Cruz10UCIBIO—Applied Molecular Biosciences Unit, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal3B’s Research Group, I3BS—Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, Barco, 4805-017 Guimarães, PortugalFaculty of Pharmacy, University of Coimbra, 3004-531 Coimbra, PortugalCenter for Neuroscience and Cell Biology—CNC, 3004-504 Coimbra, Portugal3B’s Research Group, I3BS—Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, Barco, 4805-017 Guimarães, Portugal3B’s Research Group, I3BS—Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, Barco, 4805-017 Guimarães, PortugalCIIMAR—Interdisciplinary Centre of Marine and Environmental Research, Avenida General Norton de Matos, S/N, 4450-208 Matosinhos, PortugalCIIMAR—Interdisciplinary Centre of Marine and Environmental Research, Avenida General Norton de Matos, S/N, 4450-208 Matosinhos, PortugalCIIMAR—Interdisciplinary Centre of Marine and Environmental Research, Avenida General Norton de Matos, S/N, 4450-208 Matosinhos, PortugalUCIBIO—Applied Molecular Biosciences Unit, Faculty of Pharmacy, University of Porto, 4050-313 Porto, PortugalFaculty of Pharmacy, University of Coimbra, 3004-531 Coimbra, PortugalIncorporating antioxidants into cosmetics is the mainstay for developing new products to mitigate skin aging. However, identifying novel multifunctional antioxidant ingredients with additional relevant properties that block the skin hallmarks of aging is a very striking strategy. Many natural compounds, including xanthones, have demonstrated biologically notable properties. In particular, 1,2-dihydroxy-9<i>H</i>-xanthen-9-one (1,2-DHX) has inhibitory activity against skin enzymes, and metal-chelating and radical-scavenging activities. Therefore, 1,2-DHX is an attractive molecule for cosmetic purposes. With this goal in mind, the anti-inflammatory, antioxidant, and anti-allergic potentials of 1,2-DHX were investigated. 1,2-DHX demonstrated anti-inflammatory properties by inhibiting the synthesis of specific pro-inflammatory mediators, including interleukin-6 (IL-6) and prostaglandin E2 (PGE2), in human macrophages. This xanthone did not elicit sensitization reactions and did inhibit allergic reactions triggered by a strong skin allergen, suggesting its potential as an anti-allergic compound. 1,2-DHX also revealed mitochondrial antioxidant activity by mitigating rotenone-induced oxidative stress in macrophages by up to 40%. Overall, 1,2-DHX displayed a safety profile and noteworthy biological activities, highlighting its multifunctional profile as an active cosmetic ingredient with anti-inflammatory, antioxidant, and anti-allergic properties.https://www.mdpi.com/2079-9284/11/6/215nature-inspired xanthoneanti-inflammatoryanti-allergicantioxidantmultifunctional ingredient |
| spellingShingle | Ana Jesus Sara F. Vieira Gonçalo Brites Mylène Carrascal Helena Ferreira Nuno M. Neves Honorina Cidade Madalena Pinto Emília Sousa Isabel F. Almeida Maria T. Cruz 1,2-Dihydroxy-<i>9H</i>-Xanthen-9-One, a Multifunctional Nature-Inspired Active Ingredient Cosmetics nature-inspired xanthone anti-inflammatory anti-allergic antioxidant multifunctional ingredient |
| title | 1,2-Dihydroxy-<i>9H</i>-Xanthen-9-One, a Multifunctional Nature-Inspired Active Ingredient |
| title_full | 1,2-Dihydroxy-<i>9H</i>-Xanthen-9-One, a Multifunctional Nature-Inspired Active Ingredient |
| title_fullStr | 1,2-Dihydroxy-<i>9H</i>-Xanthen-9-One, a Multifunctional Nature-Inspired Active Ingredient |
| title_full_unstemmed | 1,2-Dihydroxy-<i>9H</i>-Xanthen-9-One, a Multifunctional Nature-Inspired Active Ingredient |
| title_short | 1,2-Dihydroxy-<i>9H</i>-Xanthen-9-One, a Multifunctional Nature-Inspired Active Ingredient |
| title_sort | 1 2 dihydroxy i 9h i xanthen 9 one a multifunctional nature inspired active ingredient |
| topic | nature-inspired xanthone anti-inflammatory anti-allergic antioxidant multifunctional ingredient |
| url | https://www.mdpi.com/2079-9284/11/6/215 |
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