Black Phosphorus Tagged Responsive Strontium Hydrogel Particles for Bone Defect Repair
Abstract Hydrogel‐derived implants have proven value in bone tissue regeneration, and current efforts have concentrated on devising strategies for producing functional implants with desired structures and functions to improve therapeutic outcomes. Herein, a novel black phosphorus (BP) tagged respons...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202408284 |
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| author | Zhengwei Liu Hui Zhang Jingjing Gan Yuanjin Zhao Yongxiang Wang |
| author_facet | Zhengwei Liu Hui Zhang Jingjing Gan Yuanjin Zhao Yongxiang Wang |
| author_sort | Zhengwei Liu |
| collection | DOAJ |
| description | Abstract Hydrogel‐derived implants have proven value in bone tissue regeneration, and current efforts have concentrated on devising strategies for producing functional implants with desired structures and functions to improve therapeutic outcomes. Herein, a novel black phosphorus (BP) tagged responsive strontium (Sr) hydrogel particles are presented for bone defect repair. By applying microfluidic technology, Sr and carboxymethyl chitosan, and BP are integrated into poly(N‐isopropyl acrylamide) (pNIPAM) hydrogel matrix to generate such microparticles called pNBCSMs. Upon exposure to near‐infrared irradiation, the pNBCSMs experience volume shrinkage and provoke the extrusion of the incorporated Sr, ascribed to the photothermal conversion ability of BP and the thermosensitivity of pNIPAM. In vitro and in vivo experimental results reveal that pNBCSMs subjected to near‐infrared light display superior anti‐inflammatory, anti‐apoptotic, bacterial inhibitory, as well as osteogenesis‐promoting effects, thereby effectively improving defective cranial bone repair. These features suggest that the proposed pNBCSMs can be promising candidates for bone repair. |
| format | Article |
| id | doaj-art-85a05872430c46d8ae84c6eae0a96f41 |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-85a05872430c46d8ae84c6eae0a96f412025-01-09T11:44:45ZengWileyAdvanced Science2198-38442025-01-01121n/an/a10.1002/advs.202408284Black Phosphorus Tagged Responsive Strontium Hydrogel Particles for Bone Defect RepairZhengwei Liu0Hui Zhang1Jingjing Gan2Yuanjin Zhao3Yongxiang Wang4Department of Orthopedics Northern Jiangsu People's Hospital Clinical Teaching Hospital of Medical School Nanjing University Yangzhou 225001 ChinaDepartment of Rheumatology and Immunology Nanjing Drum Tower Hospital School of Biological Science and Medical Engineering Southeast University Nanjing 210096 ChinaDepartment of Rheumatology and Immunology Nanjing Drum Tower Hospital School of Biological Science and Medical Engineering Southeast University Nanjing 210096 ChinaDepartment of Rheumatology and Immunology Nanjing Drum Tower Hospital School of Biological Science and Medical Engineering Southeast University Nanjing 210096 ChinaDepartment of Orthopedics Northern Jiangsu People's Hospital Clinical Teaching Hospital of Medical School Nanjing University Yangzhou 225001 ChinaAbstract Hydrogel‐derived implants have proven value in bone tissue regeneration, and current efforts have concentrated on devising strategies for producing functional implants with desired structures and functions to improve therapeutic outcomes. Herein, a novel black phosphorus (BP) tagged responsive strontium (Sr) hydrogel particles are presented for bone defect repair. By applying microfluidic technology, Sr and carboxymethyl chitosan, and BP are integrated into poly(N‐isopropyl acrylamide) (pNIPAM) hydrogel matrix to generate such microparticles called pNBCSMs. Upon exposure to near‐infrared irradiation, the pNBCSMs experience volume shrinkage and provoke the extrusion of the incorporated Sr, ascribed to the photothermal conversion ability of BP and the thermosensitivity of pNIPAM. In vitro and in vivo experimental results reveal that pNBCSMs subjected to near‐infrared light display superior anti‐inflammatory, anti‐apoptotic, bacterial inhibitory, as well as osteogenesis‐promoting effects, thereby effectively improving defective cranial bone repair. These features suggest that the proposed pNBCSMs can be promising candidates for bone repair.https://doi.org/10.1002/advs.202408284black phosphorusbone defect repairhydrogelmicroparticleresponsivestrontium |
| spellingShingle | Zhengwei Liu Hui Zhang Jingjing Gan Yuanjin Zhao Yongxiang Wang Black Phosphorus Tagged Responsive Strontium Hydrogel Particles for Bone Defect Repair Advanced Science black phosphorus bone defect repair hydrogel microparticle responsive strontium |
| title | Black Phosphorus Tagged Responsive Strontium Hydrogel Particles for Bone Defect Repair |
| title_full | Black Phosphorus Tagged Responsive Strontium Hydrogel Particles for Bone Defect Repair |
| title_fullStr | Black Phosphorus Tagged Responsive Strontium Hydrogel Particles for Bone Defect Repair |
| title_full_unstemmed | Black Phosphorus Tagged Responsive Strontium Hydrogel Particles for Bone Defect Repair |
| title_short | Black Phosphorus Tagged Responsive Strontium Hydrogel Particles for Bone Defect Repair |
| title_sort | black phosphorus tagged responsive strontium hydrogel particles for bone defect repair |
| topic | black phosphorus bone defect repair hydrogel microparticle responsive strontium |
| url | https://doi.org/10.1002/advs.202408284 |
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