Inhibitory Effects of Phellodendri Cortex Against Airway Inflammation and Hyperresponsiveness in Ovalbumin-Induced Murine Asthma Model
Phellodendri cortex (PC), the dried trunk bark of <i>Phellodendron amurense</i> RUPR, has traditionally been used to treat patients who suffer from gastroenteritis, abdominal pain or diarrhea. Its major bioactive compounds include alkaloids and limonin, and many physiological activities...
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2025-04-01
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| author | Seong-Kyeom Kim Ji-Won Do Seong-Kyun Lee Jae-Ho Park Ju-Hyoung Kim Heung-Bin Lim |
| author_facet | Seong-Kyeom Kim Ji-Won Do Seong-Kyun Lee Jae-Ho Park Ju-Hyoung Kim Heung-Bin Lim |
| author_sort | Seong-Kyeom Kim |
| collection | DOAJ |
| description | Phellodendri cortex (PC), the dried trunk bark of <i>Phellodendron amurense</i> RUPR, has traditionally been used to treat patients who suffer from gastroenteritis, abdominal pain or diarrhea. Its major bioactive compounds include alkaloids and limonin, and many physiological activities including anti-microbial, anti-ulcer and anti-cancer as well as anti-inflammation have been reported. Although PC is an effective anti-inflammatory natural substance that inhibits the inflammatory response, its effect on allergic asthma has not yet been investigated. The aim of this study was to evaluate the anti-asthmatic effects of PC in an ovalbumin (OVA)-induced murine model of asthma. As a result, PC inhibited airway eosinophil accumulation, the influx of inflammatory cells, airway hyperresponsiveness (AHR), production of Th2 cytokines (IL-4, IL-5 and IL-13) and tumor necrosis factor-α (TNF-α) in the bronchoalveolar lavage fluid and/or lung, as well as OVA-specific immunoglobulin E (IgE) in the serum. Furthermore, PC suppressed the gene expression of IL-4, IL-5, IL-13, TARC and CCR3, and attenuated unique histological changes that are associated with airway inflammatory reactions including the infiltration of various inflammatory cells, collagen deposition and goblet cell hyperplasia in lung tissues. These results indicate that PC may have preventive and/or therapeutic effects for allergic asthma via the inhibition of cytokines, chemokines and chemokine receptors associated with allergic inflammation. |
| format | Article |
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| institution | OA Journals |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-04-01 |
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| spelling | doaj-art-859837dfd64b4ff8a447f233994c622f2025-08-20T02:18:04ZengMDPI AGMolecules1420-30492025-04-01308179510.3390/molecules30081795Inhibitory Effects of Phellodendri Cortex Against Airway Inflammation and Hyperresponsiveness in Ovalbumin-Induced Murine Asthma ModelSeong-Kyeom Kim0Ji-Won Do1Seong-Kyun Lee2Jae-Ho Park3Ju-Hyoung Kim4Heung-Bin Lim5Bureau of Research & Development, Chungcheongbuk-do Agricultural Research and Extension Services, Cheongju 28130, Republic of KoreaBureau of Research & Development, Chungcheongbuk-do Agricultural Research and Extension Services, Cheongju 28130, Republic of KoreaBureau of Research & Development, Chungcheongbuk-do Agricultural Research and Extension Services, Cheongju 28130, Republic of KoreaBureau of Research & Development, Chungcheongbuk-do Agricultural Research and Extension Services, Cheongju 28130, Republic of KoreaBureau of Research & Development, Chungcheongbuk-do Agricultural Research and Extension Services, Cheongju 28130, Republic of KoreaDepartment of Industrial Plant Science & Technology, Chungbuk National University, Cheongju 28644, Republic of KoreaPhellodendri cortex (PC), the dried trunk bark of <i>Phellodendron amurense</i> RUPR, has traditionally been used to treat patients who suffer from gastroenteritis, abdominal pain or diarrhea. Its major bioactive compounds include alkaloids and limonin, and many physiological activities including anti-microbial, anti-ulcer and anti-cancer as well as anti-inflammation have been reported. Although PC is an effective anti-inflammatory natural substance that inhibits the inflammatory response, its effect on allergic asthma has not yet been investigated. The aim of this study was to evaluate the anti-asthmatic effects of PC in an ovalbumin (OVA)-induced murine model of asthma. As a result, PC inhibited airway eosinophil accumulation, the influx of inflammatory cells, airway hyperresponsiveness (AHR), production of Th2 cytokines (IL-4, IL-5 and IL-13) and tumor necrosis factor-α (TNF-α) in the bronchoalveolar lavage fluid and/or lung, as well as OVA-specific immunoglobulin E (IgE) in the serum. Furthermore, PC suppressed the gene expression of IL-4, IL-5, IL-13, TARC and CCR3, and attenuated unique histological changes that are associated with airway inflammatory reactions including the infiltration of various inflammatory cells, collagen deposition and goblet cell hyperplasia in lung tissues. These results indicate that PC may have preventive and/or therapeutic effects for allergic asthma via the inhibition of cytokines, chemokines and chemokine receptors associated with allergic inflammation.https://www.mdpi.com/1420-3049/30/8/1795phellodendri cortexalkaloidasthmaairway inflammationairway hypersensitivity |
| spellingShingle | Seong-Kyeom Kim Ji-Won Do Seong-Kyun Lee Jae-Ho Park Ju-Hyoung Kim Heung-Bin Lim Inhibitory Effects of Phellodendri Cortex Against Airway Inflammation and Hyperresponsiveness in Ovalbumin-Induced Murine Asthma Model Molecules phellodendri cortex alkaloid asthma airway inflammation airway hypersensitivity |
| title | Inhibitory Effects of Phellodendri Cortex Against Airway Inflammation and Hyperresponsiveness in Ovalbumin-Induced Murine Asthma Model |
| title_full | Inhibitory Effects of Phellodendri Cortex Against Airway Inflammation and Hyperresponsiveness in Ovalbumin-Induced Murine Asthma Model |
| title_fullStr | Inhibitory Effects of Phellodendri Cortex Against Airway Inflammation and Hyperresponsiveness in Ovalbumin-Induced Murine Asthma Model |
| title_full_unstemmed | Inhibitory Effects of Phellodendri Cortex Against Airway Inflammation and Hyperresponsiveness in Ovalbumin-Induced Murine Asthma Model |
| title_short | Inhibitory Effects of Phellodendri Cortex Against Airway Inflammation and Hyperresponsiveness in Ovalbumin-Induced Murine Asthma Model |
| title_sort | inhibitory effects of phellodendri cortex against airway inflammation and hyperresponsiveness in ovalbumin induced murine asthma model |
| topic | phellodendri cortex alkaloid asthma airway inflammation airway hypersensitivity |
| url | https://www.mdpi.com/1420-3049/30/8/1795 |
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