Systematic pan-cancer analysis identifies PKNOX1 as a potential prognostic and immunological biomarker and its functional validation

Systematic pan-cancer analysis identifies PKNOX1 as a potential prognostic and immunological biomarker and its functional validation

BackgroundPBX/knotted1 homeobox 1 (PKNOX1), also known as PREP1, is a homeodomain transcription factor that has been reported to be involved in the progression of gastric adenocarcinoma and non-small cell lung cancer. However, its expression, clinical significance, and biological function in various...

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Bibliographic Details
Main Authors: Kan Liu, Yongkang Xu, Ye Mao, Shumin Fu, Shenglan Huang, Jianbing Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
PKNOX1
pan-cancer
prognostic biomarker
immune infiltration
HCC and breast cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1533690/full
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