Focus on P2X7R in microglia: its mechanism of action and therapeutic prospects in various neuropathic pain models

Focus on P2X7R in microglia: its mechanism of action and therapeutic prospects in various neuropathic pain models

Neuropathic pain (NP) is a common symptom of many diseases and is caused by direct or indirect damage to the nervous system. Tricyclic antidepressants and serotonin-norepinephrine reuptake inhibitors are typical drugs used in clinical practice to suppress pain. However, these drugs have drawbacks, i...

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Bibliographic Details
Main Authors: Kai Zhang, Rui Ran, Cheng-Jun Zhang, Linna Wang, Hai-Hong Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Pharmacology
Subjects:
neuropathic pain
P2X7R
microglia
M1/M2 polarization
cytokine
neuroinflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1555732/full
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