Research progress on natural plant metabolites targeting apoptosis for endometriosis prevention and treatment: a systematic review
Endometriosis (EMs) is a prevalent benign gynecological disorder characterized by dysmenorrhea and infertility, significantly impacting women’s health and quality of life. Currently, the pathogenesis of EMs remains incompletely elucidated. There are various side effects of drug treatment, while surg...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1624569/full |
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| author | Yang Yu Yang Yu Yufei Zhu Mengyao Gao Yu Wang Shiying Li Ying Gou |
| author_facet | Yang Yu Yang Yu Yufei Zhu Mengyao Gao Yu Wang Shiying Li Ying Gou |
| author_sort | Yang Yu |
| collection | DOAJ |
| description | Endometriosis (EMs) is a prevalent benign gynecological disorder characterized by dysmenorrhea and infertility, significantly impacting women’s health and quality of life. Currently, the pathogenesis of EMs remains incompletely elucidated. There are various side effects of drug treatment, while surgical interventions involve a certain degree of tissue trauma. Therefore, novel therapeutic drugs and clinical strategies should be developed. Apoptosis, a programmed cell death pathway, maintains tissue homeostasis, and its dysregulation is linked to various diseases and pathological complexities. Accumulating evidence suggests that abnormal apoptosis is intricately linked to the development and progression of EMs and that targeted promotion of cell apoptosis may contribute to the prevention and treatment of EMs. Natural metabolites, with their biological properties such as multipathway and multitarget effects, exhibit unique advantages in treating EMs, possibly by regulating apoptosis. This paper reviews the relationship between apoptosis and EMs. It systematically summarizes the latest progress of natural metabolites in treating EMS by regulating apoptosis, offering an innovative strategy for treating EMs. |
| format | Article |
| id | doaj-art-859306e1e5bc4367b09e9228ac2c40e1 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-859306e1e5bc4367b09e9228ac2c40e12025-08-20T03:28:13ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-07-011610.3389/fphar.2025.16245691624569Research progress on natural plant metabolites targeting apoptosis for endometriosis prevention and treatment: a systematic reviewYang Yu0Yang Yu1Yufei Zhu2Mengyao Gao3Yu Wang4Shiying Li5Ying Gou6Department of Obstetrics and Gynecology, The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin, ChinaDepartment of Obstetrics and Gynecology, Postdoctoral Mobile Station of Heilongjiang University of Traditional Chinese Medicine, Harbin, ChinaDepartment of Obstetrics and Gynecology, Heilongjiang University of Chinese Medicine, Harbin, ChinaDepartment of Obstetrics and Gynecology, Heilongjiang University of Chinese Medicine, Harbin, ChinaDepartment of Obstetrics and Gynecology, Heilongjiang University of Chinese Medicine, Harbin, ChinaDepartment of Obstetrics and Gynecology, Shaoxing Maternal and Child Health Hospital, Shaoxing, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin, ChinaEndometriosis (EMs) is a prevalent benign gynecological disorder characterized by dysmenorrhea and infertility, significantly impacting women’s health and quality of life. Currently, the pathogenesis of EMs remains incompletely elucidated. There are various side effects of drug treatment, while surgical interventions involve a certain degree of tissue trauma. Therefore, novel therapeutic drugs and clinical strategies should be developed. Apoptosis, a programmed cell death pathway, maintains tissue homeostasis, and its dysregulation is linked to various diseases and pathological complexities. Accumulating evidence suggests that abnormal apoptosis is intricately linked to the development and progression of EMs and that targeted promotion of cell apoptosis may contribute to the prevention and treatment of EMs. Natural metabolites, with their biological properties such as multipathway and multitarget effects, exhibit unique advantages in treating EMs, possibly by regulating apoptosis. This paper reviews the relationship between apoptosis and EMs. It systematically summarizes the latest progress of natural metabolites in treating EMS by regulating apoptosis, offering an innovative strategy for treating EMs.https://www.frontiersin.org/articles/10.3389/fphar.2025.1624569/fullnatural plant metabolitesapoptosisendometriosisclinical translationsignaling pathways |
| spellingShingle | Yang Yu Yang Yu Yufei Zhu Mengyao Gao Yu Wang Shiying Li Ying Gou Research progress on natural plant metabolites targeting apoptosis for endometriosis prevention and treatment: a systematic review Frontiers in Pharmacology natural plant metabolites apoptosis endometriosis clinical translation signaling pathways |
| title | Research progress on natural plant metabolites targeting apoptosis for endometriosis prevention and treatment: a systematic review |
| title_full | Research progress on natural plant metabolites targeting apoptosis for endometriosis prevention and treatment: a systematic review |
| title_fullStr | Research progress on natural plant metabolites targeting apoptosis for endometriosis prevention and treatment: a systematic review |
| title_full_unstemmed | Research progress on natural plant metabolites targeting apoptosis for endometriosis prevention and treatment: a systematic review |
| title_short | Research progress on natural plant metabolites targeting apoptosis for endometriosis prevention and treatment: a systematic review |
| title_sort | research progress on natural plant metabolites targeting apoptosis for endometriosis prevention and treatment a systematic review |
| topic | natural plant metabolites apoptosis endometriosis clinical translation signaling pathways |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1624569/full |
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