DDX17 promotes DENV-2 replication via interaction with viral dsRNA and G3BP1
Dengue virus (DENV) is one of the major arboviruses that pose a serious threat to global human health. However, there is currently no specific antiviral drug available for the treatment of DENV infection. DDX17, a member of the DExD/H-box helicase family, has been implicated in the replication proce...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | International Journal of Medical Microbiology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1438422125000104 |
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| author | Peijun Han Wei Ye Hongwei Ma Yangchao Dong Xin Lv He Liu Linfeng Cheng Liang Zhang Sumin Li Yingfeng Lei Fanglin Zhang |
| author_facet | Peijun Han Wei Ye Hongwei Ma Yangchao Dong Xin Lv He Liu Linfeng Cheng Liang Zhang Sumin Li Yingfeng Lei Fanglin Zhang |
| author_sort | Peijun Han |
| collection | DOAJ |
| description | Dengue virus (DENV) is one of the major arboviruses that pose a serious threat to global human health. However, there is currently no specific antiviral drug available for the treatment of DENV infection. DDX17, a member of the DExD/H-box helicase family, has been implicated in the replication processes of various viruses. Our research group discovered that during the early stages of dengue virus replication, DDX17 promotes viral replication and suppresses the activity of the IFN promoter. Furthermore, DDX17 binds to viral dsRNA and interacts with G3BP1, a component of stress granules (SGs), to inhibit SG formation, thereby enhancing viral replication. By elucidating the role of DDX17 in the early stages of dengue virus replication, our findings provide valuable insights into host-pathogen interactions during DENV infection, offering potential therapeutic perspectives. |
| format | Article |
| id | doaj-art-8590cfabaa754ce889f0e1864c8d38cc |
| institution | Kabale University |
| issn | 1438-4221 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Medical Microbiology |
| spelling | doaj-art-8590cfabaa754ce889f0e1864c8d38cc2025-08-20T03:45:30ZengElsevierInternational Journal of Medical Microbiology1438-42212025-06-0131915165410.1016/j.ijmm.2025.151654DDX17 promotes DENV-2 replication via interaction with viral dsRNA and G3BP1Peijun Han0Wei Ye1Hongwei Ma2Yangchao Dong3Xin Lv4He Liu5Linfeng Cheng6Liang Zhang7Sumin Li8Yingfeng Lei9Fanglin Zhang10Department of Aerospace Hygiene, School of Aerospace Medicine, Air Force Medical University (the Fourth Military Medical University), Xi'an, Shaanxi 710032, ChinaDepartment of Microbiology & Pathogen Biology, School of Basic Medicine, Air Force Medical University (the Fourth Military Medical University), Xi'an, Shaanxi 710032, ChinaDepartment of Microbiology & Pathogen Biology, School of Basic Medicine, Air Force Medical University (the Fourth Military Medical University), Xi'an, Shaanxi 710032, ChinaDepartment of Microbiology & Pathogen Biology, School of Basic Medicine, Air Force Medical University (the Fourth Military Medical University), Xi'an, Shaanxi 710032, ChinaDepartment of Microbiology & Pathogen Biology, School of Basic Medicine, Air Force Medical University (the Fourth Military Medical University), Xi'an, Shaanxi 710032, ChinaDepartment of Microbiology & Pathogen Biology, School of Basic Medicine, Air Force Medical University (the Fourth Military Medical University), Xi'an, Shaanxi 710032, ChinaDepartment of Microbiology & Pathogen Biology, School of Basic Medicine, Air Force Medical University (the Fourth Military Medical University), Xi'an, Shaanxi 710032, ChinaDepartment of Microbiology & Pathogen Biology, School of Basic Medicine, Air Force Medical University (the Fourth Military Medical University), Xi'an, Shaanxi 710032, ChinaDepartment of Aerospace Hygiene, School of Aerospace Medicine, Air Force Medical University (the Fourth Military Medical University), Xi'an, Shaanxi 710032, ChinaDepartment of Microbiology & Pathogen Biology, School of Basic Medicine, Air Force Medical University (the Fourth Military Medical University), Xi'an, Shaanxi 710032, ChinaDepartment of Microbiology & Pathogen Biology, School of Basic Medicine, Air Force Medical University (the Fourth Military Medical University), Xi'an, Shaanxi 710032, China; Corresponding author.Dengue virus (DENV) is one of the major arboviruses that pose a serious threat to global human health. However, there is currently no specific antiviral drug available for the treatment of DENV infection. DDX17, a member of the DExD/H-box helicase family, has been implicated in the replication processes of various viruses. Our research group discovered that during the early stages of dengue virus replication, DDX17 promotes viral replication and suppresses the activity of the IFN promoter. Furthermore, DDX17 binds to viral dsRNA and interacts with G3BP1, a component of stress granules (SGs), to inhibit SG formation, thereby enhancing viral replication. By elucidating the role of DDX17 in the early stages of dengue virus replication, our findings provide valuable insights into host-pathogen interactions during DENV infection, offering potential therapeutic perspectives.http://www.sciencedirect.com/science/article/pii/S1438422125000104Dengue virusDDX17IFN-βG3BP1DExD/H-boxSG |
| spellingShingle | Peijun Han Wei Ye Hongwei Ma Yangchao Dong Xin Lv He Liu Linfeng Cheng Liang Zhang Sumin Li Yingfeng Lei Fanglin Zhang DDX17 promotes DENV-2 replication via interaction with viral dsRNA and G3BP1 International Journal of Medical Microbiology Dengue virus DDX17 IFN-β G3BP1 DExD/H-box SG |
| title | DDX17 promotes DENV-2 replication via interaction with viral dsRNA and G3BP1 |
| title_full | DDX17 promotes DENV-2 replication via interaction with viral dsRNA and G3BP1 |
| title_fullStr | DDX17 promotes DENV-2 replication via interaction with viral dsRNA and G3BP1 |
| title_full_unstemmed | DDX17 promotes DENV-2 replication via interaction with viral dsRNA and G3BP1 |
| title_short | DDX17 promotes DENV-2 replication via interaction with viral dsRNA and G3BP1 |
| title_sort | ddx17 promotes denv 2 replication via interaction with viral dsrna and g3bp1 |
| topic | Dengue virus DDX17 IFN-β G3BP1 DExD/H-box SG |
| url | http://www.sciencedirect.com/science/article/pii/S1438422125000104 |
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