Mechanistic role of long non-coding RNAs in the pathogenesis of metabolic dysfunction-associated steatotic liver disease and fibrosis
Metabolic dysfunction-associated steatotic liver disease (MASLD), previously referred to as non-alcoholic fatty liver disease, encompasses a broad range of hepatic metabolic disorders primarily characterised by the disruption of hepatic lipid metabolism, hepatic lipid accumulation and steatosis. Sev...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2024-12-01
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| Series: | eGastroenterology |
| Online Access: | https://egastroenterology.bmj.com/content/2/4/e100115.full |
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| author | Henry Wade Kaichao Pan Bingrui Zhang Wenhua Zheng Qiaozhu Su |
| author_facet | Henry Wade Kaichao Pan Bingrui Zhang Wenhua Zheng Qiaozhu Su |
| author_sort | Henry Wade |
| collection | DOAJ |
| description | Metabolic dysfunction-associated steatotic liver disease (MASLD), previously referred to as non-alcoholic fatty liver disease, encompasses a broad range of hepatic metabolic disorders primarily characterised by the disruption of hepatic lipid metabolism, hepatic lipid accumulation and steatosis. Severe cases of MASLD might progress to metabolic dysfunction-associated steatohepatitis, characterised by hepatic inflammation, hepatocyte ballooning degeneration, activation of hepatic stellate cells (HSCs) and fibrogenesis. It may further progress to hepatocellular carcinoma. In the liver, long non-coding RNAs (lncRNAs) target multiple metabolic pathways in hepatocytes, HSCs, and Kupffer cells at different stages of MASLD and liver fibrosis. In this study, we overview recent findings on the potential role of lncRNAs in the pathogenesis of MASLD and liver fibrosis via modulation of de novo lipid synthesis, fatty acid β-oxidation, lipotoxicity, oxidative stress, metabolic inflammation, mammalian target of rapamycin signalling, apoptosis, ubiquitination and fibrogenesis. We critically assess the literature reports that investigate the complex interplay between lncRNA, microRNA and key mediators in liver injury, in both human participants and animal models of MASLD and liver fibrosis. We also highlight the therapeutic potential of lncRNAs in chronic liver diseases. |
| format | Article |
| id | doaj-art-858d0ccf54634746a8e69daaa89d9bd1 |
| institution | OA Journals |
| issn | 2766-0125 2976-7296 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMJ Publishing Group |
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| series | eGastroenterology |
| spelling | doaj-art-858d0ccf54634746a8e69daaa89d9bd12025-08-20T02:35:24ZengBMJ Publishing GroupeGastroenterology2766-01252976-72962024-12-012410.1136/egastro-2024-100115Mechanistic role of long non-coding RNAs in the pathogenesis of metabolic dysfunction-associated steatotic liver disease and fibrosisHenry Wade0Kaichao Pan1Bingrui Zhang2Wenhua Zheng3Qiaozhu Su41 School of Biological Sciences, Queen`s University Belfast, Belfast, UK2 Endocrinology Group, Advocate Illinois Masonic Medical Center, Chicago, Illinois, USA1 School of Biological Sciences, Queen`s University Belfast, Belfast, UK3 Faculty of Health Science, University of Macau, Macau, China1 School of Biological Sciences, Queen`s University Belfast, Belfast, UKMetabolic dysfunction-associated steatotic liver disease (MASLD), previously referred to as non-alcoholic fatty liver disease, encompasses a broad range of hepatic metabolic disorders primarily characterised by the disruption of hepatic lipid metabolism, hepatic lipid accumulation and steatosis. Severe cases of MASLD might progress to metabolic dysfunction-associated steatohepatitis, characterised by hepatic inflammation, hepatocyte ballooning degeneration, activation of hepatic stellate cells (HSCs) and fibrogenesis. It may further progress to hepatocellular carcinoma. In the liver, long non-coding RNAs (lncRNAs) target multiple metabolic pathways in hepatocytes, HSCs, and Kupffer cells at different stages of MASLD and liver fibrosis. In this study, we overview recent findings on the potential role of lncRNAs in the pathogenesis of MASLD and liver fibrosis via modulation of de novo lipid synthesis, fatty acid β-oxidation, lipotoxicity, oxidative stress, metabolic inflammation, mammalian target of rapamycin signalling, apoptosis, ubiquitination and fibrogenesis. We critically assess the literature reports that investigate the complex interplay between lncRNA, microRNA and key mediators in liver injury, in both human participants and animal models of MASLD and liver fibrosis. We also highlight the therapeutic potential of lncRNAs in chronic liver diseases.https://egastroenterology.bmj.com/content/2/4/e100115.full |
| spellingShingle | Henry Wade Kaichao Pan Bingrui Zhang Wenhua Zheng Qiaozhu Su Mechanistic role of long non-coding RNAs in the pathogenesis of metabolic dysfunction-associated steatotic liver disease and fibrosis eGastroenterology |
| title | Mechanistic role of long non-coding RNAs in the pathogenesis of metabolic dysfunction-associated steatotic liver disease and fibrosis |
| title_full | Mechanistic role of long non-coding RNAs in the pathogenesis of metabolic dysfunction-associated steatotic liver disease and fibrosis |
| title_fullStr | Mechanistic role of long non-coding RNAs in the pathogenesis of metabolic dysfunction-associated steatotic liver disease and fibrosis |
| title_full_unstemmed | Mechanistic role of long non-coding RNAs in the pathogenesis of metabolic dysfunction-associated steatotic liver disease and fibrosis |
| title_short | Mechanistic role of long non-coding RNAs in the pathogenesis of metabolic dysfunction-associated steatotic liver disease and fibrosis |
| title_sort | mechanistic role of long non coding rnas in the pathogenesis of metabolic dysfunction associated steatotic liver disease and fibrosis |
| url | https://egastroenterology.bmj.com/content/2/4/e100115.full |
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