Repair Injured Heart by Regulating Cardiac Regenerative Signals
Cardiac regeneration is a homeostatic cardiogenic process by which the sections of malfunctioning adult cardiovascular tissues are repaired and renewed employing a combination of both cardiomyogenesis and angiogenesis. Unfortunately, while high-quality regeneration can be performed in amphibians and...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/6193419 |
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| author | Wen-Feng Cai Guan-Sheng Liu Lei Wang Christian Paul Zhi-Li Wen Yigang Wang |
| author_facet | Wen-Feng Cai Guan-Sheng Liu Lei Wang Christian Paul Zhi-Li Wen Yigang Wang |
| author_sort | Wen-Feng Cai |
| collection | DOAJ |
| description | Cardiac regeneration is a homeostatic cardiogenic process by which the sections of malfunctioning adult cardiovascular tissues are repaired and renewed employing a combination of both cardiomyogenesis and angiogenesis. Unfortunately, while high-quality regeneration can be performed in amphibians and zebrafish hearts, mammalian hearts do not respond in kind. Indeed, a long-term loss of proliferative capacity in mammalian adult cardiomyocytes in combination with dysregulated induction of tissue fibrosis impairs mammalian endogenous heart regenerative capacity, leading to deleterious cardiac remodeling at the end stage of heart failure. Interestingly, several studies have demonstrated that cardiomyocyte proliferation capacity is retained in mammals very soon after birth, and cardiac regeneration potential is correspondingly preserved in some preadolescent vertebrates after myocardial infarction. There is therefore great interest in uncovering the molecular mechanisms that may allow heart regeneration during adult stages. This review will summarize recent findings on cardiac regenerative regulatory mechanisms, especially with respect to extracellular signals and intracellular pathways that may provide novel therapeutics for heart diseases. Particularly, both in vitro and in vivo experimental evidences will be presented to highlight the functional role of these signaling cascades in regulating cardiomyocyte proliferation, cardiomyocyte growth, and maturation, with special emphasis on their responses to heart tissue injury. |
| format | Article |
| id | doaj-art-858ac338e24d46d384041c982dbe78f2 |
| institution | OA Journals |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-858ac338e24d46d384041c982dbe78f22025-08-20T02:08:55ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/61934196193419Repair Injured Heart by Regulating Cardiac Regenerative SignalsWen-Feng Cai0Guan-Sheng Liu1Lei Wang2Christian Paul3Zhi-Li Wen4Yigang Wang5Department of Pathology & Lab Medicine, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USADepartment of Pharmacology & Cell Biophysics, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USADepartment of Pathology & Lab Medicine, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USADepartment of Pathology & Lab Medicine, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USAInfectious Disease Hospital, Nanchang University, Nanchang, Jiangxi 330002, ChinaDepartment of Pathology & Lab Medicine, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USACardiac regeneration is a homeostatic cardiogenic process by which the sections of malfunctioning adult cardiovascular tissues are repaired and renewed employing a combination of both cardiomyogenesis and angiogenesis. Unfortunately, while high-quality regeneration can be performed in amphibians and zebrafish hearts, mammalian hearts do not respond in kind. Indeed, a long-term loss of proliferative capacity in mammalian adult cardiomyocytes in combination with dysregulated induction of tissue fibrosis impairs mammalian endogenous heart regenerative capacity, leading to deleterious cardiac remodeling at the end stage of heart failure. Interestingly, several studies have demonstrated that cardiomyocyte proliferation capacity is retained in mammals very soon after birth, and cardiac regeneration potential is correspondingly preserved in some preadolescent vertebrates after myocardial infarction. There is therefore great interest in uncovering the molecular mechanisms that may allow heart regeneration during adult stages. This review will summarize recent findings on cardiac regenerative regulatory mechanisms, especially with respect to extracellular signals and intracellular pathways that may provide novel therapeutics for heart diseases. Particularly, both in vitro and in vivo experimental evidences will be presented to highlight the functional role of these signaling cascades in regulating cardiomyocyte proliferation, cardiomyocyte growth, and maturation, with special emphasis on their responses to heart tissue injury.http://dx.doi.org/10.1155/2016/6193419 |
| spellingShingle | Wen-Feng Cai Guan-Sheng Liu Lei Wang Christian Paul Zhi-Li Wen Yigang Wang Repair Injured Heart by Regulating Cardiac Regenerative Signals Stem Cells International |
| title | Repair Injured Heart by Regulating Cardiac Regenerative Signals |
| title_full | Repair Injured Heart by Regulating Cardiac Regenerative Signals |
| title_fullStr | Repair Injured Heart by Regulating Cardiac Regenerative Signals |
| title_full_unstemmed | Repair Injured Heart by Regulating Cardiac Regenerative Signals |
| title_short | Repair Injured Heart by Regulating Cardiac Regenerative Signals |
| title_sort | repair injured heart by regulating cardiac regenerative signals |
| url | http://dx.doi.org/10.1155/2016/6193419 |
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