Diabetes Mellitus and Liver Surgery: The Effect of Diabetes on Oxidative Stress and Inflammation
Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycaemia and high morbidity worldwide. The detrimental effects of hyperglycaemia include an increase in the oxidative stress (OS) response and an enhanced inflammatory response. DM compromises the ability of the liver to regenerat...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2018/2456579 |
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| author | Mariana Mendes-Braz Joilson O. Martins |
| author_facet | Mariana Mendes-Braz Joilson O. Martins |
| author_sort | Mariana Mendes-Braz |
| collection | DOAJ |
| description | Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycaemia and high morbidity worldwide. The detrimental effects of hyperglycaemia include an increase in the oxidative stress (OS) response and an enhanced inflammatory response. DM compromises the ability of the liver to regenerate and is particularly associated with poor prognosis after ischaemia-reperfusion (I/R) injury. Considering the growing need for knowledge of the impact of DM on the liver following a surgical procedure, this review aims to present recent publications addressing the effects of DM (hyperglycaemia) on OS and the inflammatory process, which play an essential role in I/R injury and impaired hepatic regeneration after liver surgery. |
| format | Article |
| id | doaj-art-8581d107dd0c4ea08b7fc0c71c9293f3 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-8581d107dd0c4ea08b7fc0c71c9293f32025-08-20T03:37:47ZengWileyMediators of Inflammation0962-93511466-18612018-01-01201810.1155/2018/24565792456579Diabetes Mellitus and Liver Surgery: The Effect of Diabetes on Oxidative Stress and InflammationMariana Mendes-Braz0Joilson O. Martins1Laboratory of Immunoendocrinology, Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences of University Sao Paulo (FCF/USP), São Paulo, SP, BrazilLaboratory of Immunoendocrinology, Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences of University Sao Paulo (FCF/USP), São Paulo, SP, BrazilDiabetes mellitus (DM) is a metabolic disorder characterized by hyperglycaemia and high morbidity worldwide. The detrimental effects of hyperglycaemia include an increase in the oxidative stress (OS) response and an enhanced inflammatory response. DM compromises the ability of the liver to regenerate and is particularly associated with poor prognosis after ischaemia-reperfusion (I/R) injury. Considering the growing need for knowledge of the impact of DM on the liver following a surgical procedure, this review aims to present recent publications addressing the effects of DM (hyperglycaemia) on OS and the inflammatory process, which play an essential role in I/R injury and impaired hepatic regeneration after liver surgery.http://dx.doi.org/10.1155/2018/2456579 |
| spellingShingle | Mariana Mendes-Braz Joilson O. Martins Diabetes Mellitus and Liver Surgery: The Effect of Diabetes on Oxidative Stress and Inflammation Mediators of Inflammation |
| title | Diabetes Mellitus and Liver Surgery: The Effect of Diabetes on Oxidative Stress and Inflammation |
| title_full | Diabetes Mellitus and Liver Surgery: The Effect of Diabetes on Oxidative Stress and Inflammation |
| title_fullStr | Diabetes Mellitus and Liver Surgery: The Effect of Diabetes on Oxidative Stress and Inflammation |
| title_full_unstemmed | Diabetes Mellitus and Liver Surgery: The Effect of Diabetes on Oxidative Stress and Inflammation |
| title_short | Diabetes Mellitus and Liver Surgery: The Effect of Diabetes on Oxidative Stress and Inflammation |
| title_sort | diabetes mellitus and liver surgery the effect of diabetes on oxidative stress and inflammation |
| url | http://dx.doi.org/10.1155/2018/2456579 |
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