Approaches to modeling cancer metastasis: from bench to bedside
Cancer metastasis modeling requires multidisciplinary approaches that integrate experimental, computational, and clinical research to unravel the complexities of cancer spread). By deepening our understanding of the metastatic process, researchers can efficiently and precisely develop targeted thera...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1602489/full |
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| _version_ | 1849243174037356544 |
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| author | Leiyu Sun Yajuan Zhou Maoxu Yin Fei Wang Lijuan Yang |
| author_facet | Leiyu Sun Yajuan Zhou Maoxu Yin Fei Wang Lijuan Yang |
| author_sort | Leiyu Sun |
| collection | DOAJ |
| description | Cancer metastasis modeling requires multidisciplinary approaches that integrate experimental, computational, and clinical research to unravel the complexities of cancer spread). By deepening our understanding of the metastatic process, researchers can efficiently and precisely develop targeted therapies and personalized treatment strategies to relieve the burden of metastasis on patients. In this review, we highlight the critical roles of experimental models in advancing knowledge of metastasis, identifying therapeutic targets, evaluating treatment strategies, and improving patient outcomes. These models serve as essential tools for translational research and drug discovery in the fight against metastatic cancer |
| format | Article |
| id | doaj-art-857f72bdfdc247cf84f4fedc7a345936 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-857f72bdfdc247cf84f4fedc7a3459362025-08-20T03:59:35ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-08-011510.3389/fonc.2025.16024891602489Approaches to modeling cancer metastasis: from bench to bedsideLeiyu Sun0Yajuan Zhou1Maoxu Yin2Fei Wang3Lijuan Yang4Department of Gastroenterology, Binzhou Medical University Hospital, Binzhou, Shandong, ChinaDepartment of Gastroenterology, Binzhou Medical University Hospital, Binzhou, Shandong, ChinaDepartment of Gastroenterology, Binzhou Medical University Hospital, Binzhou, Shandong, ChinaMedical Research Center, Binzhou Medical University Hospital, Binzhou, ChinaMedical Research Center, Binzhou Medical University Hospital, Binzhou, ChinaCancer metastasis modeling requires multidisciplinary approaches that integrate experimental, computational, and clinical research to unravel the complexities of cancer spread). By deepening our understanding of the metastatic process, researchers can efficiently and precisely develop targeted therapies and personalized treatment strategies to relieve the burden of metastasis on patients. In this review, we highlight the critical roles of experimental models in advancing knowledge of metastasis, identifying therapeutic targets, evaluating treatment strategies, and improving patient outcomes. These models serve as essential tools for translational research and drug discovery in the fight against metastatic cancerhttps://www.frontiersin.org/articles/10.3389/fonc.2025.1602489/fullcancer metastasismetastasis modelspreclinical researchpatient-derived models (PDX, organoids)therapeutic evaluationmetastasis mechanisms |
| spellingShingle | Leiyu Sun Yajuan Zhou Maoxu Yin Fei Wang Lijuan Yang Approaches to modeling cancer metastasis: from bench to bedside Frontiers in Oncology cancer metastasis metastasis models preclinical research patient-derived models (PDX, organoids) therapeutic evaluation metastasis mechanisms |
| title | Approaches to modeling cancer metastasis: from bench to bedside |
| title_full | Approaches to modeling cancer metastasis: from bench to bedside |
| title_fullStr | Approaches to modeling cancer metastasis: from bench to bedside |
| title_full_unstemmed | Approaches to modeling cancer metastasis: from bench to bedside |
| title_short | Approaches to modeling cancer metastasis: from bench to bedside |
| title_sort | approaches to modeling cancer metastasis from bench to bedside |
| topic | cancer metastasis metastasis models preclinical research patient-derived models (PDX, organoids) therapeutic evaluation metastasis mechanisms |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1602489/full |
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