Osthole Protects against Acute Lung Injury by Suppressing NF-κB-Dependent Inflammation
Inflammation is a key factor in the pathogenesis of ALI. Therefore, suppression of inflammatory response could be a potential strategy to treat LPS-induced lung injury. Osthole, a natural coumarin extract, has been reported to protect against acute kidney injury through an anti-inflammatory mechanis...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2018/4934592 |
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| _version_ | 1849401328347906048 |
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| author | Yiyi Jin Jianchang Qian Xin Ju Xiaodong Bao Li Li Suqing Zheng Xiong Chen Zhongxiang Xiao Xuemei Chen Weiwei Zhu Weixin Li Wencan Wu Guang Liang |
| author_facet | Yiyi Jin Jianchang Qian Xin Ju Xiaodong Bao Li Li Suqing Zheng Xiong Chen Zhongxiang Xiao Xuemei Chen Weiwei Zhu Weixin Li Wencan Wu Guang Liang |
| author_sort | Yiyi Jin |
| collection | DOAJ |
| description | Inflammation is a key factor in the pathogenesis of ALI. Therefore, suppression of inflammatory response could be a potential strategy to treat LPS-induced lung injury. Osthole, a natural coumarin extract, has been reported to protect against acute kidney injury through an anti-inflammatory mechanism, but its effect on ALI is poorly understood. In this study, we investigated whether osthole ameliorates inflammatory sepsis-related ALI. Results from in vitro studies indicated that osthole treatment inhibited the LPS-induced inflammatory response in mouse peritoneal macrophages through blocking the nuclear translocation of NF-κB. Consistently, the in vivo studies indicated that osthole significantly prolonged the survival of septic mice which was accompanied by inflammation suppression. In the ALI mouse model, osthole effectively inhibited the development of lung tissue injury, leukocytic recruitment, and cytokine productions, which was associated with inhibition of NF-κB nuclear translocation. These findings provide evidence that osthole was a potent inhibitor of NF-κB and inflammatory injury and suggest that it could be a promising anti-inflammatory agent for therapy of septic shock and acute lung injury. |
| format | Article |
| id | doaj-art-857f2ea0e9c7432baab507820bf78fce |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-857f2ea0e9c7432baab507820bf78fce2025-08-20T03:37:47ZengWileyMediators of Inflammation0962-93511466-18612018-01-01201810.1155/2018/49345924934592Osthole Protects against Acute Lung Injury by Suppressing NF-κB-Dependent InflammationYiyi Jin0Jianchang Qian1Xin Ju2Xiaodong Bao3Li Li4Suqing Zheng5Xiong Chen6Zhongxiang Xiao7Xuemei Chen8Weiwei Zhu9Weixin Li10Wencan Wu11Guang Liang12Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaChemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaThe Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaChemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaChemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaChemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaChemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaChemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaChemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaChemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaChemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaThe Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaChemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaInflammation is a key factor in the pathogenesis of ALI. Therefore, suppression of inflammatory response could be a potential strategy to treat LPS-induced lung injury. Osthole, a natural coumarin extract, has been reported to protect against acute kidney injury through an anti-inflammatory mechanism, but its effect on ALI is poorly understood. In this study, we investigated whether osthole ameliorates inflammatory sepsis-related ALI. Results from in vitro studies indicated that osthole treatment inhibited the LPS-induced inflammatory response in mouse peritoneal macrophages through blocking the nuclear translocation of NF-κB. Consistently, the in vivo studies indicated that osthole significantly prolonged the survival of septic mice which was accompanied by inflammation suppression. In the ALI mouse model, osthole effectively inhibited the development of lung tissue injury, leukocytic recruitment, and cytokine productions, which was associated with inhibition of NF-κB nuclear translocation. These findings provide evidence that osthole was a potent inhibitor of NF-κB and inflammatory injury and suggest that it could be a promising anti-inflammatory agent for therapy of septic shock and acute lung injury.http://dx.doi.org/10.1155/2018/4934592 |
| spellingShingle | Yiyi Jin Jianchang Qian Xin Ju Xiaodong Bao Li Li Suqing Zheng Xiong Chen Zhongxiang Xiao Xuemei Chen Weiwei Zhu Weixin Li Wencan Wu Guang Liang Osthole Protects against Acute Lung Injury by Suppressing NF-κB-Dependent Inflammation Mediators of Inflammation |
| title | Osthole Protects against Acute Lung Injury by Suppressing NF-κB-Dependent Inflammation |
| title_full | Osthole Protects against Acute Lung Injury by Suppressing NF-κB-Dependent Inflammation |
| title_fullStr | Osthole Protects against Acute Lung Injury by Suppressing NF-κB-Dependent Inflammation |
| title_full_unstemmed | Osthole Protects against Acute Lung Injury by Suppressing NF-κB-Dependent Inflammation |
| title_short | Osthole Protects against Acute Lung Injury by Suppressing NF-κB-Dependent Inflammation |
| title_sort | osthole protects against acute lung injury by suppressing nf κb dependent inflammation |
| url | http://dx.doi.org/10.1155/2018/4934592 |
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